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M Rucquoi

Publications and source records attributed to M Rucquoi.

11 recordsLinked to original sources
PubMed1987

Computer registration and processing of census data for an anesthesiology department.

The description of a set of programs running on a HP-1000 mainframe computer is outlined. They allow easy census data input, storage and handling according to the growing needs of an academic anesthesia department of about twenty physicians, delivering more than 8000 anesthetic procedures a year. Various kinds of reports can be generated that are useful not only for the department as a whole or for the anesthesiologists independently, but also for the optimization of the use of the operation theatres. Special attention has been given to the respect the medical secrecy: identification of the patient's records is under direct control of a physician, is impossible without a deciphering routine and is not performed unless really needed.

Anesthesia Department, Hospital↗
PubMed1984

Clinical assessment of midazolam for induction of anesthesia.

Intravenous midazolam was tried as a hypnotic agent for induction of anesthesia in 63 surgical patients. Three dosages were used: 0.2, 0.3 and 0.4 mg/kg body weight. Indices of induction, changes of vital parameters, incidence of apnea and side effects and the duration of the drug effect on central nervous system functions were evaluated. No significant differences were observed between the effects of the different doses of midazolam on the cardiac and respiratory parameters. The drug provided a satisfactory degree of sleep in all patients of maximal intensity at three minutes but anesthetic induction was not achieved in several patients of each dose group (overall failure rate 11%). A short-lasting apnea was seen in 13% of the patients and seemed not related to the administered dose of midazolam. The awareness of the surroundings was satisfactorily obtunded by the anti-recall effect of the drug. The sedative effects of midazolam on central nervous system functions lasted fairly long. Indeed, mental arousal, sensory functions and muscle tone still had not returned to preinjection values 20 min after midazolam administration. A reliable relationship between dose of midazolam and intensity of cerebral depressive effect was not evident.

Adolescent↗
PubMed1983

Cardiovascular responses to large doses of alfentanil and fentanyl.

The cardiovascular effects of alfentanil and fentanyl were measured during an i.v. anaesthesia technique administered to 12 patients scheduled for lower abdominal surgery. A single bolus of fentanyl 30 micrograms kg-1 (group I, n = 5) or alfentanil 120 micrograms kg-1 (group II, n = 7) was given after the induction of anaesthesia and repeated 1 h later, immediately before the surgical incision. In the absence of surgical manipulation, both drugs induced a significant bradycardia and decreases in arterial pressure, cardiac index, RCWI and LCWI, while SVI and preload equivalents remained stable. During the surgical procedure the same changes were observed for at least 1 h in group I and for, at most, 20 min in group II. The lack of profound cardiovascular depression and the improvement of the myocardial oxygen demand:supply ratio brought about by fentanyl make it a satisfactory technique for long surgical procedures. Alfentanil provided a similar cardiovascular stability only for 20 min.

Abdomen↗
PubMed1983

Cardiac and circulatory effects of high-dose meptazinol in anaesthetized patients.

The haemodynamic effects of three doses of meptazinol were studied in 9 anaesthetized patients before surgery. Three patients of each group received a bolus injection of 2, 3, or 4 mg/kg. In all groups, cardiac output, mean arterial pressure, heart rate and the rate pressure product fell significantly. The systemic and pulmonary vascular resistance remained unchanged. The pulmonary capillary wedge pressure and mean pulmonary artery pressure were stable throughout the 90 minutes observation period. None of the doses of meptazinol had a deleterious effect on myocardial contractility although the observed changes were more pronounced with the 4 mg/kg dose. It is concluded that meptazinol improves the myocardial oxygen demand/supply ratio mainly through its negative chronotropic effect and a reduction of afterload.

Anesthesia↗
PubMed1982

Pharmacokinetics of alfentanil in man.

The distribution and elimination kinetics of alfentanil, a new short-acting analgesic, were studied in five surgical patients. Its behavior, following a bolus injection of 120 micrograms/ml, was compatible with a three-compartment open-model distribution. The disappearance of the drug from plasma was rapid (t 1/2 pi = 3.5 +/- 1.3 minutes, t 1/2 alpha = 16.8 +/- 6.4 minutes) with 96.4% of the drug eliminated from plasma in 1 hour, indicating extensive transfer to the remote peripheral compartment. This was followed by a slower elimination phase with a t 1/2 beta of 94 +/- 38 minutes. Total volume of distribution was 1.03 +/- 0.50 L/kg. Total plasma clearance was 456 +/- 155 ml/min. The short analgesic effect of this drug might be attributed to the rapid displacement of the drug from the central and intermediate compartments to the remote peripheral compartment. Approximately 25% of the injected dose was present in the remote peripheral compartment 30 to 60 minutes after alfentanil administration. As the return of drug from this peripheral to the central compartment is slower than the elimination rate of the drug, it could be the rate-limiting step in the elimination of alfentanil from the body.

Alfentanil↗
PubMed1976

A comparative study of etomidate and methohexital as induction agents for analgesic anesthesia.

Two hundred current surgical procedures were done in adult patients using neuroleptanalgesia with either methohexital (1 mg/kg) or etomidate induction (0.3 mg/kg) in half of the cases. The cardiovascular function was less altered with etomidate (less occurrence of tachycardia, blood pressure drops or systolo-diastolic pinching). The etomidate dosage chosen more often gave an immediate satisfactory sleep. However, with methohexital induction, less signs of awakening were observed during the surgical procedure. The frequent postoperative somnolence also points, although indirectly, to a longer residual effect of the barbiturate. Both drugs sometimes gave erythema. The injection of etomidate was more frequently painful in the arm. On the other hand, hiccups occurred with methohexital induction only. Etomidate induced myoclonia in one-third of the cases premedicated with diazepam and after preliminary injection of a minimal amount of fentanyl. Without these precautions, myoclonia can occur in two-thirds of the patients. However, these myoclonia are bothersome and of prolonged duration in rare instances and would be of real annoyance only when this drug would be used alone for surgical procedures of short duration where perfect patient immobility is required. We therefore conclude and confirm that etomidate is a good induction agent for neuroleptanalgesia anesthesia procedures.

Anesthesia↗
PubMedDate not supplied

Case for hybrid "fetal growth curves": a population-based estimation of normal fetal size across gestational age.

We hypothesized that normal fetal size would be most appropriately characterized by a hybrid cross-sectional growth chart combining preterm (< 37 weeks) ultrasound-estimated fetal weights and full-term (> or = 37 weeks) birthweights. Concurrent cross-sectional charts defining fetal size were constructed from 1,331 ultrasound-estimated fetal weights (US) (24-40 weeks) and 9,553 birthweights (BW) (24-43 weeks) from a population of singleton offspring without anomalies. Percentile ranks (10th-90th) were established for both charts. Best-fit third-order equations generated by least-squares regression analysis were compared between the two growth charts. Weight distributions (percentile ranks) were compared separately across gestational age, and for preterm and term gestation. Statistical analysis was performed by chi-square analysis where appropriate with P < .05 accepted for significance. The BW standard failed to appropriately characterize ultrasound-estimated fetal weight across gestational age. (US: < 10th%, n = 42 [3.1%]; 10-90th%, n = 978 [73.5%]; > 90th%, n = 311 [23.4%], P < .001). The characterization of both preterm and term weights was significantly different between fetal size curves. The birthweight growth curve limited the designation of fetal growth restriction (< 10th%) in the preterm ultrasound group to 1.6% of subjects examined (n = 17, P < .001). In contrast, at term the ultrasound estimation of normal fetal weight (between the 10th and 90th percentiles) included 84% of the term birthweights (P < .05). Cross-sectional sonographically defined fetal size curves provide optimal characterization of preterm fetal weight as estimated by ultrasound. In term gestation, a normative size chart derived from ultrasound estimated fetal weight appears to broaden or overrepresent the tails of the distribution. Hybrid size curves, combining preterm ultrasound estimated fetal weight and term birthweight, provide the best estimate of the normal range of fetal weight across gestational age.

Birth Weight↗