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Biomedical subjects

M Rudolph

Publications and source records attributed to M Rudolph.

88 records · Page 5Linked to original sources
PubMed1975

[Presence of RNA-and DNA-tumor viruses within a cell line from mouse spleen and thymus (author's transl)].

Cells of spleen and thymus from mice infected with Rauscher leukaemia virus were cultivated in vitro. A new cell type repeatedly grew out of this cell line. Electron-optically, RNA--viruses and DNA-viruses were found within the new lines, but there was no cell containing both viruses at the same time. According to experimental results in rats, the DNA virus is polyoma-like. The importance the presence of two different viruses within the same cell is discussed.

Animals↗
PubMed1975

[Ultracytochemical studies on leukemic cells].

The present survey of ultracytochemical investigations in the cells of the Graffi and Rauscher leukaemic systems is intended to throw a light on the place of replication and on the incorporation of cell specific material into the virus. The successful evidence of incorporating certain enzymes associated to the membrane into the virus envelope could have a significance in so far as this process can be used to explain the appearance of cytotropism in certain kinds of virus to a target cell.

Acid Phosphatase↗
PubMedDate not supplied

Do neocortical pyramidal neurons display stochastic resonance?

Neocortical pyramidal neurons in vivo are subject to an intense synaptic background activity that has a significant impact on various electrophysiological properties and dendritic integration. Using detailed biophysical models of a morphologically reconstructed neocortical pyramidal neuron, in which synaptic background activity was simulated according to recent measurements in cat parietal cortex in vivo, we show that the responsiveness of the cell to additional periodic subthreshold stimuli can be significantly enhanced through mechanisms similar to stochastic resonance. We compare several paradigms leading to stochastic resonance-like behavior, such as varying the strength or the correlation in the background activity. A new type of resonance-like behavior was obtained when the correlation was varied, in which case the responsiveness is sensitive to the statistics rather than the strength of the noise. We suggest that this type of resonance may be relevant to information processing in the cerebral cortex.

Action Potentials↗
PubMedDate not supplied

Epidemiology of congestive heart failure in three ethnic groups.

Congestive heart failure (CHF) is a leading cause of morbidity, disability, and mortality in old age, but little is known about the epidemiology of this condition in free-living minority populations. To determine the prevalence of CHF and associated risk factors in a multiethnic community, a population sample of 2759 elderly (i.e., 65 years of age and older) African American (AA), Hispanic-Cuban (HC), and white non-Hispanic (WNH) men and women from Miami-Dade County, Florida, were examined. There were 153 (5.6%) cases of self-reported CHF in the sample. The unadjusted prevalence rate of CHF was virtually identical among elderly AA (4.8%) and WNH (4.9%) but was significantly (p=0.04) lower than the rate among HC (6.8%). Sex- and ethnic-specific analyses showed that the highest prevalence rate of CHF was among HC women (8.2%). A multiple logistic analysis was used to calculate the odds ratio (OR) and 95% confidence interval (CI) of CHF in relation to age, sex, ethnicity, medical history, and smoking and alcohol drinking habits. Age (65-74 vs. 75-84; OR 1.7; CI 1.2-2.4; p=0.01), HC ethnic group (OR 1.5; CI 1.0-2.4; p=0.05), history of hypertension (OR 1.5; CI 1.1-2.1; p=0.02), history of myocardial infarction (OR 2.3; CI 1.5-3.5; p=0.0001), and history of diabetes mellitus (OR 1.9; CI 1.3-2.8; p=0.001) were directly, significantly, and independently associated with the prevalence of self-reported CHF. The findings here confirm those of prior studies in elderly white US residents, which indicate that heart attack, hypertension, and diabetes mellitus are major risk factors for CHF. The results also show that elderly AA and WNH have similar CHF prevalence rates. The higher CHF prevalence in elderly HC women found in this study requires further investigation. (c)2001 by CHF, Inc.

Journal Article↗