Biomedical subjects

M Runkel

Publications and source records attributed to M Runkel.

51 records · Page 3Linked to original sources

PubMed1994

[Technique of plate osteosynthesis of the femur].

When plating is performed for fixation of complex femoral fractures the need for medial buttress to give durable weight-bearing ability of the bone is mandatory. However the means of achieving this is controversial. Many authors are in favour of mechanical reconstruction of the medial buttress, if necessary with a bone graft. Alternatively, medial buttress can be achieved by means of a technique allowing biological fracture healing, which is only possible, when the vascularity of all fragments is preserved. In 39 cases of osteosynthesis with plates for complex femoral fractures the bridging technique was used at surgery, to avoid denudation of the fragments. All osteosyntheses were performed without the application of bone clamps. After minimal exposure of the femur at the lateral side only, the plates were fixed in the main proximal fragment with one screw, in the case of blade plates the blade was fixed without bone clamps too. Afterwards the main distal fragment was drawn up to the plate and fixed directly and with a screw. In 9 cases the plates were inserted behind the vastus lateralis muscle, preserving its continuity, and fixed distally with another screw. After fine checking of the fracture alignment for rotation and length the plates were fixed with four or five screws in each main fragment, all at sites distant from the fracture. Meanwhile, all 39 fractures have consolidated. There were no cases of infection. Bone grafting was necessary in 8 cases. Only in 2 cases were the defects located in the medial area. In 37 of the 39 osteosyntheses an excellent medial buttress was achieved by bone healing.(ABSTRACT TRUNCATED AT 250 WORDS)

Bone Plates↗

PubMed1993

Pathogenesis and prophylaxis of circulatory reactions during total hip replacement.

Circulatory reactions such as a drop in blood pressure, bradycardia, cardiac arrest, and even intraoperative death after insertion of the stem are well known events during total hip replacement. The present paper reports bone marrow intravasation after rise of intramedullary pressure in the femoral cavity during insertion of hip prostheses, demonstrated by intraoperative transesophageal echocardiography. In an animal study, the ultrasound echoes were identified as "mixed emboli" consisting of a core of bone marrow surrounded by thrombus. These results suggested the use of an intramedullary plug to restrict the intravasation of bone marrow. A trial was undertaken in 60 total hip replacement operations. The first 30 were performed using the conventional technique without an intramedullary plug. In a second series of 30 operations, an intramedullary plug made of cancellous bone taken from the resected femoral head was placed 2 cm below the expected location of the tip of the stem. The cement was applied from distal to proximal by syringe. After implantation of the prosthesis using the conventional technique, a significant drop in blood pressure was observed. In the second series, the drop in blood pressure did not occur. In conclusion, it was demonstrated that effective venting of the bone marrow cavity by a bore hole, and avoidance of compression of the bone-marrow-filled distal femoral cavity by using a plug, results in effective prevention of circulatory reactions: no drop in blood pressure occurred. The use of an intramedullary plug is discussed and recommended.

Aged↗

PubMed1993

[Experimental studies in weakening the stability of the trochanter major by lateral fenestration].

A major disadvantage of the usual 130 degree angle plates when handling the fracture of the neck of the femur is the fact that the lateral corticalis of the femur is almost completely interrupted by the broad window at a biomechanical important and highly strained location. This often leads to the complications such as the breaking off of the greater trochanter or lack of stability etc. The experiment examines ten pairs of human femora for a decrease of stability, which results from the lateral fenestration for the osteosynthesis. One of the two bones out of a pair received a slit at a right angle concerning the axis of the femur, the other one a round hole. The slit was made into the proximal lateral femur as if preparing for the installation of a 130 degree angle plate. On the corresponding spot of the second bone a round hole was drilled. The remaining stability of the compact bone was measured by experimental pulling on the greater trochanter. Under the assumption that left and right femur have about the same stability, which was proven in one of the experiments, a significant disadvantage was found for the relatively wide slit.

Biomechanical Phenomena↗

PubMed1993

[Treatment and results of ruptures of the patellar tendon].

Ruptures of the patellar ligament are rather uncommon. In younger individuals they are due to adequate trauma, in older individuals spontaneous ruptures occur after inadequate trauma. We observed eight traumatic (mean = 26.5 years) and eleven spontaneous ruptures (mean = 57.5 years) between 1980 and 1990. There is no alternative to surgical repair of the ruptured or torn-out patellar ligament. Tendon-repair with supportive wire-looping and early functional physiotherapy produces a good functional result. The outcome of patients treated in this manner shows persisting slightly muscular atrophy of minor degree and limited knee mobility with only a little all-day handicap.

Adult↗

PubMed1993

Pathogenesis and clinical relevance of bone marrow embolism in medullary nailing--demonstrated by intraoperative echocardiography.

For the clarification of pulmonary impairment after medullary nailing of femoral fractures, the intramedullary pressure in the femoral cavity during the operative procedure was investigated. In addition, an intraoperative transoesophageal echocardiography was performed which revealed two phenomena occurring once the intramedullary pressure had increased: snow-flurry and configured emboli. An experimental study in sheep was performed in order to define the substrata of the sonographic echoes. The level of intrafemoral pressure which would result in bone marrow intravasation and the substrata of the echocardiographic echoes were studied in sheep by applying pressure to the femoral cavity. Sonography of the distal vena cava by laparotomy and macroscopic and histological investigation of the venous blood received throughout a proximal subdiaphragmal venotomy were undertaken. The intrafemoral pressure peaks correlated with the appearance of sonographic echoes in both patients and sheep. Snow-flurry is an indication of small amounts of bone marrow and already appears at an intramedullary pressure of 50 mmHg, which can easily occur during movement of non-stabilised fractures (values up to 90 mmHg were observed)--configured emboli consist of a core of bone marrow surrounded by thrombotic aggregate and only appeared at pressure increases of over 200 mmHg in the animal experiments. During medullary nailing in patients the intrafemoral pressure increases up to 200-600 mmHg in all reaming procedures. Configured emboli were seen in 8 of 20 patients being treated with reamed nailing. In five nailing procedures performed using the unreamed technique, no pressure increases greater than 70 mmHg and no configured emboli were observed. I.v. injected bone marrow results in pulmonary impairment.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed1993

[The value of the radiologic Lachman test in anterior cruciate ligament ruptures].

A radiologic Lachman test of both knees was performed in 35 patients with surgically verified tears of the anterior cruciate ligament (ACL). We found a mean anterior drawer of 3.2 mm for uninjured joints, 4.5 mm for isolated ACL-tears and 10.8 mm for complex ACL-injuries. Sensitivity of the radiological Lachman test was 95% for complex ACL-injuries as only 23% in case of isolated ACL-ruptures. Failure of diagnosis due to clinical investigation in case of ACL-ruptures could not be proved by means of radiological Lachman-test. Technical requirements and radiation exposure are further disadvantages. Clinically doubtful cases of acute knee injuries should therefore be investigated with other diagnostic procedures.

Adolescent↗

PubMed1993

[Detection of primarily unrecognized fractures in severely injured patients by skeletal scintigraphy].

Even in despite of diligent investigation clinical and radiological diagnostics can leave fractures unrecognized in seriously injured patients. Bone-scans of 53 patients revealed 68 additional fractures. In 45% of all cases the initial diagnosis was altered, 19% resulted in therapeutical consequences. Routine diagnostics should be supplemented by a bone-scan if clinical and radiological findings are not in line. A bone-scan can exclude any osseous lesion and can survey the full extent of injuries especially in the disoriented or unconscious patient.

Adolescent↗

PubMed1993

[Development of thromboses in hip joint endoprostheses. A study with color-coded duplex ultrasound].

After 102 hip replacements in a surgical technique that avoids bone-marrow intravasation as much as possible, color-coded duplex sonography revealed thigh thrombi in only 4 cases without any signs of thrombosis. This rate is lower than that found in all other comparable studies. The investigations stress the role of bone-marrow intravasation in the induction of deep vein thrombosis in hip replacement. With an optimal surgical technique, thigh thrombi can be greatly reduced in hip replacements, which have a higher rate than all other operations.

Aged↗

PubMed1993

[Nuclear magnetic tomography in shoulder dislocation].

Sixty-two patients with anterior shoulder dislocations were examined by magnetic resonance imaging (MRI). After a primary dislocation, 30 patients showed 23 (77%) tears of the glenoid labrum, 13 (45%) anterior-inferior separation of the capsula, 24 (83%) Hill-Sachs lesions, 6 fractures of the greater tuberosity and 4 glenoid rim fractures. Thirty-two patients with recurrent shoulder dislocation had 14 (44%) tears and 15 (47%) defects of the glenoid labrum, 16 (50%) anterior-inferior separation of the capsula, 28 (88%) Hill-Sachs lesions and 3 glenoid rim fractures. MRI permits complete non-invasive documentation of glenohumeral instability if joint effusion is present. In the absence of joint effusion, diagnostic accuracy can be improved by application of a contrast medium.

Adolescent↗

PubMed1992

A simple and rapid technique to process formalin-fixed, paraffin-embedded tissues for the detection of viruses by the polymerase chain reaction.

The use of chelating resin in a simple, rapid and efficient pre-treatment protocol to process formalin-fixed, paraffin-embedded specimens for the polymerase chain reaction (PCR) is described and compared to other pre-treatment techniques. With this modified PCR protocol, a variety of human autopsy and biopsy specimens were investigated for presence of DNA of human papilomaviruses, cytomegalovirus or Epstein-Barr virus. These viruses were detected in a productive or non-/low-productive state. Amplimers generated ranged from 88 to 450 base pairs length. Under the specified technical conditions, a considerable range of DNA molecules can be amplified from paraffin-embedded material, some older than 10 years.

Acquired Immunodeficiency Syndrome↗

PubMed1992

[MR tomography of injuries of the medial collateral ligaments of the knee joint].

Frequency and characteristics of lesions of the medial collateral ligaments (MCL) were studied by MRI in 155 patients with trauma to the knee. There were abnormalities of the MCL in 38% of cases with ligamentous injuries and in 27% these were combined with meniscal tears. 11% of these patients showed isolated rupture of MCL and as a result of the MRI findings were treated conservatively. By means of T2*-weighted images the individual lesions could be accurately localised. Characteristic findings have been defined.

Humans↗

PubMed1992

[MR tomography versus CT arthrography in glenohumeral instabilities].

In a prospective study the diagnostic value of MRI compared to CT arthrography (CT-A) was evaluated in 26 patients with 27 instable shoulder joints. Surgical and/or arthroscopic correlation was available in all cases. Both methods showed a high accuracy (96% CT-A, 94% MRI) in the evaluation of the glenoid labrum. CT-A was significantly superior to MRI in the detection of capsular lesions (sensitivity 96% vs. 44%, accuracy 96% vs. 72%, negative predictive value 96% vs. 67%). CT-A and MRI results regarding humeral head fractures were similar; fractures of the glenoid rim were better detected by CT-A, the difference, however, was statistically not significant. Overall, CT-A proved to be superior to MRI, as lesions of the joint capsule were shown with greater certainty.

Adolescent↗

PubMed1992

[The value of MR tomography in acute shoulder dislocations].

24 patients up to two weeks after primary traumatic shoulder dislocation were examined at 0.5 and 1.5 T. Surgical and/or arthroscopic correlation was available in 13, CT-arthrographic correlation in 16 patients. A joint effusion allowing sufficient evaluation of the capsulolabral complex was present in 21/24 (87.5%) cases. 11/14 patients with combined dislocated detachments of the glenoid labrum and capsular lesions were subsequently operated upon. Marrow edema of the humeral head was found in 16/19 Hill-Sachs lesions and in 4/5 fractures of the greater tuberosity. Two patients presented with a lesion of the long biceps tendon associated with rotator cuff tears and were also subsequently operated upon. MRI performed shortly after primary traumatic shoulder dislocation allows a comprehensive evaluation of the intraarticular lesions and decisively influences further therapy.

Adolescent↗

PubMed1991

[Simultaneous rupture of the patellar tendon and the contralateral quadriceps tendon in chronic kidney insufficiency].

Simultaneous ruptures of the patellar tendon and the contralateral quadriceps tendon, happening either spontaneously or with a preceding minor trauma, is a rare event especially in young patients. Major degenerative changes in the tendons' structure are most often a prerequisite for a trauma such as this. The reasons for these excessive pathological findings in tendon tissue structure can be chronic renal failure and resulting secondary hyperparathyroidism. The causal relationship will be discussed in front of a patients case history followed by a review of the relevant literature.

Adult↗

PubMedDate not supplied

[Paget's disease of the proximal ulna--a rare monostotic manifestation].

Bone changes of the upper extremity are rare manifestations of the M. Paget disease. Most frequently the disease affects the lower extremities, the pelvis followed by the calvarium and others. The rare asymptomatic, monostotic manifestation of Paget's disease of the left proximal ulnae of a 59 year old woman and the way of diagnosis is described. Symptomatic skeletal lesions are detected by radiological examination, bone scintigraphy reveals asymptomatic lesions. Laboratory tests (Alkaline serum phosphatase, Hydroxyproline in urine) monitor the activity of the disease.

Alkaline Phosphatase↗