Irreversible pulmonary interstitial fibrosis developed 36 days after a single course of BCNU (total, 400 mg) in a patient with a malignant brain tumor. The case is unique in that irreversible changes developed shortly after a single course of BCNU whereas heretofore such permanent changes have been associated only with multiple courses of the drug (2,000-4,000 mg). This suggests that individual differences in the local sensitivity of lung tissue may be as important as the dose of the drug in determining whether irreversible fibrosis will develop.

Brain Neoplasms↗

PubMedDate not supplied

Retroperitoneal fibrosis presenting as colonic dysfunction: CT diagnosis.

In a patient who presented with pelvic pain and changed bowel habits, barium enema and sigmoidoscopic examinations demonstrated a nonspecific asymmetric narrowing of the colon at the rectosigmoid junction with normal mucosal appearance. Computed tomography revealed the etiology to be retroperitoneal fibrosis with pelvic extension and entrapment of the colon at this level. The importance of CT in diagnosis of this unusual manifestation of retroperitoneal fibrosis is discussed.

Colonic Diseases↗