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Biomedical subjects

M Rupani

Publications and source records attributed to M Rupani.

8 recordsLinked to original sources
PubMed1990

Analysis of 135 autopsy eyes for ocular involvement in leukemia.

To explain the marked variation in the reported incidence of how often leukemic cells infiltrate the eye in fatal cases of leukemia, we tested the hypothesis that ocular leukemic infiltration is related to the peripheral leukocyte count during the final hours of life. We reviewed tissue sections, as well as autopsy and clinical records, from 135 patients who had fatal leukemia and had their eyes examined after death at Duke University Medical Center. Infiltrates of leukemic cells were found in the eyes of 42 of 135 patients (31.1%), with the choroid being the most frequently involved site. We detected a significant positive correlation between the ocular leukemic infiltration and an agonal leukocyte count as well as the severity of systemic disease. Differences in the agonal circulating leukocyte count may partly explain variations in the incidence of leukemic infiltrates in different postmortem studies.

Choroid↗
PubMed1988

Radiology and pathology in canine acalculous cholecystitis.

Although the value of hepatobiliary scan and ultrasonography are well established in calculous cholecystitis, their role in acute acalculous cholecystitis (AAC) is less certain. This study assesses the diagnostic reliability of these tests in AAC chemically induced in 10 dogs with rutin, a compound known to induce AAC. Ultrasonography demonstrated pericholecystic fluid or wall thickening in 8 of 10 dogs. Hepatobiliary scans were abnormal in only 2 of 9 dogs. Pathologic evaluation showed significant abnormalities in all gallbladders. Our studies confirm the usefulness of ultrasonography in diagnosing AAC and suggest caution in using a normal hepatobiliary scan to exclude the diagnosis of AAC.

Animals↗
PubMed1986

A hypothesis on the allantoic origin of the distal midgut.

No satisfactory explanation for the absence of the ileocecal portion of the digestive system in the newborns with cloacal exstrophy has been offered previously. This is a report of such a case in which the lymphocytes and plasma cells were used as tissue markers to identify the origin of the lymphatic-rich ileocecal portion of the digestive tract. The absence of these cells, in this case demonstrated immunohistochemically, is suggestive of a dual origin of the midgut. Normal embryogenesis of the digestive system is reviewed and the possibility of participation of the allantois, in addition to the yolk sac, in the embryogenesis of the ileocecal segment of the gastrointestinal tract is discussed.

Allantois↗
PubMed1984

Human chorionic gonadotropin-secreting pure dysgerminoma.

A young woman with a preoperative diagnosis of molar pregnancy was found to have a pure dysgerminoma in the right ovary. Immunohistochemical study of formalin-fixed tissue revealed human chorionic gonadotropin-secreting small stromal cells. This is in contradistinction to previous reports of functioning dysgerminomas, in which the secretory activity was associated with the presence of syncytiotrophoblasts and chorionic tissue. Reports of ultrastructural and biochemical analyses of pure dysgerminomas confirming this observation are discussed.

Adult↗
PubMed1984

Contribution of education to cost-effective care of microcytic, hypochromic anemia.

Through a handbook, a seminar, and multiple opportunities for reinforcement in clinical settings, faculty in family medicine conducted an educational program that presented cost-effective practice standards for the care of anemia patients to resident physicians. A comparison of the quality and cost of anemia care by the residents before and during the program ascertained its value. The quality of patient care by residents rose significantly during the program. In addition, the residents' utilization of tests, therapy, and clinic visits and attendant costs reached more appropriate levels. These results should encourage faculty to respond to the current national need for the development of educational materials on cost-effective care of patients with common health problems.

Anemia, Hypochromic↗
PubMed1982

Type and screen.

Explore the source record for details and available documents.

Blood Grouping and Crossmatching↗
PubMed1982

Acute myelofibrosis.

This report describes a 20-year-old patient with rapidly fatal fibrosis of the bone marrow associated with leukopenia, anemia, and large number of myeloblasts in peripheral blood. The bone marrow revealed extensive fibrosis and hyperplasia of the myeloblasts and megakaryocytes. The patient failed to respond to chemotherapy, developed fungal and bacterial infections, and died within less than six weeks after the diagnosis was made. The case is reported to support the concept of acute myelofibrosis and to suggest that further cases should be studied to define the clinicopathologic features of this disorder.

Acute Disease↗