M Rybczynski | PubMed Health

PubMed2005

[Improved analysis of left ventricular function using three-dimensional echocardiography].

Left ventricular geometry and function are important pathophysiologic and prognostic parameters. However, especially in patients with cardiac pathologies left ventricular geometry can be complex. Quantification of left ventricular volumes using conventional two-dimensional echocardiography is only possible when simplifying assumptions of left ventricular geometry are made. In contrast three-dimensional echocardiography allows direct quantification of left ventricular volumes even in complex distortions of left ventricular shape. The availability of real-time three-dimensional echocardiography has brought this technique into clinical practice. Three-dimensional echocardiography is a technique that may be used as a routine echocardiographic method in the near future.

Cardiac Volume↗

PubMed2003

[Marfan syndrome: pathogenesis, phenotypes and diagnostic value, of various imaging techniques].

Marfan syndrome is a genetic disorder with autosomal dominant inheritance. It is caused by mutations in the fibrillin-1 gene and leads to different disease manifestations. Seventy-five percent of the affected individuals develop an aneurysm of the ascending aorta, 41 % suffer from aortic dissections, and 93 % die of cardiovascular diseases. Skeletal changes occur in two-thirds of the patients, and lens dislocation is observed in 60 to 80 %. Without treatment, the life expectancy is 32 +/- 16 years. However, Marfan patients can live up to 60 years if they receive optimal therapy. Early diagnosis of the disease and it 's life-threatening sequelae is the prerequisite for early therapy. Radiologic diagnostic techniques are of pivotal importance in this context as they allow the identification of major and minor disease manifestations and the detection of severe dilatations and aortic dissections at an early stage. This overview describes the radiologically detectable multiple changes seen in Marfan syndrome and explains the diagnostic value of various imaging techniques in the diagnosis and therapy of Marfan syndrome.

Bone and Bones↗