[Research, publications, statistics and ethics].
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Biomedical subjects
Publications and source records attributed to M S Añez.
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Prostaglandins GE2 produces on the gallbladder a rise in intraluminal pressure, an increase in in intraluminal secretion, improves gallbladder contraction and decreases its absorption capacity. In this study, patients who received indomethacin twice a day by rectum, showed a significant reduction in volume and area of gallbladder after 24 and 48 hours (P < 0.05). The gallbladder volume after 24 hours had SEM 9.13 cm3, 95% CI 55.28 + 73.49 (P < 0.05). Score pain reduction after 24 hours was also significant (P < 0.001). The patients who underwent the classical Baralcina treatment of one IV vial BID showed a reduction in diameter and area of gallbladder but this was not statistically significant (P < 0.10). Reduction of volume at 24 hours was SEM 5.34 cm3 95% CI - 64.72 + 76.60 P 0.10 NS; and at 48 hours SEM 3.5 cm3, 95% CI 59.52% + 66.52 P 0.40. Score pain reduction was only significant at 48 hours P 0.001. The number of patients without pain at 24 hours was significantly higher in the indomethacin group ESP 0.21; 95% CI 0.46 + 0.88 P 0.001. In conclusion indomethacin is a useful medication in the treatment of acute cholecystitis and biliary colic due to its anti-prostaglandin effect on the gallbladder.
Nutritional evaluation is required to treat patients with hepatic disease. A significant correlation was demonstrated between real body weights lean body mass (LMB) with arm muscular area (AMA) (P less than 0.001); LBM of patients with ascites Vs without ascites showed significant differences (P less than 0.02). No significant differences (P greater than 0.1) was demonstrated, when we used the AMA between patients with Vs without ascites. Albumin values showed slight depletion on 20%; 12% had moderate and 4% had very severe depletion, but 64% of patients had normal values. Albumin-transferrin showed very good correlation (P less than 0.001); but there was no correlation between albumin-AMA, transferrin-AMA, transferrin-MMM and albumin-MMM (P greater than 0.05). The lymphocytic count on 53.33% was normal, 37.67% showed light depletion and 9% had moderate; PPDs was greater than 10mm in 60.86%; normal in 17.36%, and not reactive in 21.75%. AMA is a real and ideal nutritional evaluation method, because it is able to correct the errors due to the presence of ascites.
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