Biomedical subjects

M S Ayers

Publications and source records attributed to M S Ayers.

6 recordsLinked to original sources

PubMed2001

Treatment of diarrhea caused by Giardia intestinalis and Entamoeba histolytica or E. dispar: a randomized, double-blind, placebo-controlled study of nitazoxanide.

A prospective randomized, double-blind, placebo-controlled study was conducted to assess the efficacy and safety of nitazoxanide in the treatment of diarrhea caused by Giardia intestinalis or Entamoeba histolytica and/or E. dispar in 89 adults and adolescents, 22 of whom were diagnosed with G. intestinalis, 53 with E. histolytica and/or E. dispar, and 14 with both G. intestinalis and E. histolytica and/or E. dispar. The study medication was administered as 1 nitazoxanide 500-mg tablet or a matching placebo twice daily for 3 days. Thirty-eight (81%) of 47 patients in the nitazoxanide treatment group resolved diarrhea within 7 days (median, 3 days) after initiation of treatment, versus 17 (40%) of 42 in the placebo group (P=.0002). With its efficacy in treating a broad spectrum of enteric protozoan pathogens, nitazoxanide could play an important role in the management of diarrhea caused by enteric protozoa, reducing morbidity and costs associated with these diarrheal illnesses.

Adolescent↗

PubMed2001

Treatment of diarrhea caused by Cryptosporidium parvum: a prospective randomized, double-blind, placebo-controlled study of Nitazoxanide.

A prospective randomized, double-blind, placebo-controlled study was conducted in 50 adults and 50 children from the Nile delta of Egypt, to evaluate the efficacy of nitazoxanide in treating diarrhea caused by Cryptosporidium parvum. Nitazoxanide was administered in 500-mg doses twice daily for 3 days in adults and adolescents, in 200-mg doses twice daily for 3 days in children aged 4-11 years, and in 100-mg doses twice daily for 3 days in children aged 1-3 years. At 7 days after initiation of therapy, diarrhea had resolved in 39 (80%) of the 49 patients in the nitazoxanide treatment group, compared with 20 (41%) of 49 in the placebo group (P<.0001). Diarrhea was resolved in most patients receiving nitazoxanide within 3 or 4 days of treatment initiation. Nitazoxanide treatment reduced the duration of both diarrhea (P<.0001) and oocyst shedding (P<.0001).

Adolescent↗

PubMed2000

A mechanistic account of the mirror effect for word frequency: a computational model of remember-know judgments in a continuous recognition paradigm.

A theoretical account of the mirror effect for word frequency and of dissociations in the pattern of responding Remember vs. Know (R vs. K) for low- and high-frequency words was tested both empirically and computationally by comparing predicted with observed data theory in 3 experiments. The SAC (Source of Activation Confusion) theory of memory makes the novel prediction of more K responses for high- than for low-frequency words, for both old and new items. Two experiments used a continuous presentation and judgment paradigm that presented words up to 10 times. The computer simulation closely modeled the pattern of results, fitting new Know and Remember patterns of responding at each level of experimental presentation and for both levels of word frequency for each participant. Experiment 3 required list discrimination after each R response (Group 1) or after an R or K response (Group 2). List accuracy was better following R responses. All experiments were modeled using the same parameter values.

Adult↗

PubMed1996

Partial matching in the Moses illusion: response bias not sensitivity.

Previous research has demonstrated that people have enormous difficulty in detecting distortions in such questions as, "How many animals of each kind did Moses take in the Ark?" Reder and Kusbit (1991) argued that the locus of the effect must be the existence of a partial-match process. Other research has suggested that this partial-match process operates at the word level and that, with adequate focus on the relevant word, the Moses illusion is greatly diminished. The present experimental results argue that those conclusions were based on a shift in response criterion with no concomitant change in ability to detect distortions. Furthermore, the data suggest that the matching process operates below the word level, at the level of distinctive features.

Adult↗

PubMedDate not supplied

A double-'blind' placebo-controlled study of nitazoxanide in the treatment of cryptosporidial diarrhoea in AIDS patients in Mexico.

Sixty-six patients with human immunodeficiency virus infection and diarrhoea caused by Cryptosporidium parvum were enrolled in a double-'blind' placebo-controlled study to evaluate the safety and efficacy of nitazoxanide in the treatment of cryptosporidiosis related to the acquired immune deficiency syndrome. Patients were randomly assigned to one of 3 treatment groups and received either 500 mg twice daily of nitazoxanide, 1000 mg twice daily of nitazoxanide, or placebo orally for 14 d; the patients on nitazoxanide then crossed over to placebo while the placebo patients crossed over to nitazoxanide therapy at either the high or low dose depending on their randomization. Three post-treatment faecal examinations were conducted on days 15, 22 and 29 following initiation of treatment: patients were considered 'cured' if none revealed any C. parvum oocysts. Both doses of nitazoxanide produced parasitological cure rates superior to the placebo responses (12/19 [63%, P = 0.016] for patients receiving 1 g/d and 10/15 [67%, P = 0.013] for those receiving 2 g/d). Parasitological cure was correlated with the complete resolution of the diarrhoeal syndrome in 19 of the 22 treated patients who were considered parasitologically cured (86%). Both doses of nitazoxanide were well tolerated by the patients.

AIDS-Related Opportunistic Infections↗

PubMedDate not supplied

Computed tomographic evaluation of dinosaur egg shell integrity.

The purpose of this study was to determine whether computed tomography (CT) could be used to identify hatching holes in partially embedded dinosaur eggs. One Faveololithus and two Dendroolithus eggs were examined using a fourth generation CT scanner. The eggs were partially embedded in a fossilized sediment matrix, with the exposed portion of the shell appearing intact. In CT images of all three eggs, the shells appeared hyperdense relative to the matrix. Hatching holes were visible as large gaps in the embedded portion of the shell, with inwardly displaced shell fragments. It was concluded that CT is an effective technique for nondestructively assessing dinosaur egg shell integrity.

Animals↗