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Biomedical subjects

M S Bhatia

Publications and source records attributed to M S Bhatia.

At least 19 recordsLinked to original sources
PubMed2002

Event related evoked potentials in dementia: role of vitamin E.

Dementia is a common cognitive syndrome reflecting a wide spread chronic progressive disease as an extension to normal aging process. Oxidative stress has been implicated in dementia and antioxidants have become attractive therapeutic agents. Among the antioxidants vitamin E is the most potent in the treatment of dementia. Study was conducted in 20 patients suffering from dementia in the age group of 66-74 and in 20 age and sex matched controls. Latency of the P3 component of event related evoked potential (ERP) showed an increase from 338.65 +/- 42.22 msec in control group to 348.9 +/- 46.38 msec in patients of dementia. In control group P3 latency decreased from 338.65 +/- 42.22 msec to 331.6 +/- 38.75 msec after Vitamin E therapy. In patients of dementia latency decreased significantly from 348.9 +/- 46.38 msec to 324.62 +/- 44.25 msec after vitamin therapy for one month. P3 amplitude in controls and demented was 7.2 +/- 3.62 mu v and 7.07 +/- 3.73 mu v respectively. After vitamin E therapy a statistically significant increase in amplitude (P < 0.05) was observed in controls (9.34 +/- 5.04 mu v) and in patients of dementia (9.58 +/- 5.24 mu v). The study suggests that the latency and amplitude of P3 were not significantly different in control and dementia patients, while vitamin E supplementation (oral 800 mg per day for 30 days) decreased the latency and increased the P3 amplitude in both the control and dementia patients. Our study further supports that Vitamin E supplementation, because of its antioxidant property might be decreasing oxidative stress, which may lead to improvement in cognitive pool of generator neurons of P3.

Aged↗
PubMed2000

Psychosocial profile of suicide ideators, attempters and completers in India.

The study aims to determine the psychological profile of suicide ideators, attempters and completers in a tertiary care teaching hospital. A total of 260 suicidal ideators, 58 attempters and 55 completers were studied. The majority of ideators, attempters and completers were 26-35 years of age, males (except attempters who were predominantly females), married, literate up to high school, employed (ideators) or housewives (attempters and completers). The suicide ideators, attempters and completers who had a past history of attempt were 6.9%, 24.1% and 18.2% respectively. Family history of attempted suicide or completed suicide was also common among patients suffering from depression. In suicidal ideators, mixed anxiety and depressive disorder was the most common psychiatric diagnosis followed by major depression and schizophrenia. Among suicide attempters, adjustment disorder with depression was the most common diagnosis. The most common method of suicide attempt was organophosphorus compound intake whereas in suicide completers, the most common method in use was hanging. The patients with suicidal ideation or attempt need careful evaluation, early intervention and long term follow up.

Adjustment Disorders↗
PubMed2000

Delusional parasitosis: a clinical profile.

OBJECTIVE: Delusional parasitosis is a form of monohypochondriacal psychosis, a condition sometimes encountered in psychiatric or primary care practice. The outcome of this condition is not well known. METHOD: In the present study, a series of fifty-two consecutive cases of delusional parasitosis is reported. RESULTS: A majority of cases (92%) had insidious onset. The duration of symptoms in all but two cases was six months or more. Twenty-six cases presented with a delusion of infestation by insects over the body and twenty-three cases with a delusion of insects crawling over the scalp. Three cases had associated diabetes mellitus, five cases had leprosy, five cases dementia, four cases had depression, and three cases presented with trichotillomania. Pimozide was used in forty-six cases, amitriptyline and fluoxetine in three cases each. Twenty-eight cases (54%) showed complete remission while receiving pharmacotherapy, eighteen cases showed partial improvement, and six cases did not respond to treatment. CONCLUSION: Further studies are warranted to study the treatment and outcome of this important psychiatric disorder.

Adult↗
PubMed2000

Allergy to tartrazine in psychotropic drugs.

BACKGROUND: High psychiatric morbidity has been reported among those who complain of food intolerance or allergy. Many cases of food allergy or intolerance to drugs are not due to allergy to the food or drugs themselves, but to the additives used for coloring, flavoring, preserving, thickening, emulsifying, or stabilizing the product. Of various coloring dyes used, tartrazine (FD & C yellow no. 5) is the color most frequently incriminated in producing allergic reactions. The exact epidemiology and pattern of allergic reactions to tartrazine in psychotropic drugs have not been frequently studied and reported. METHOD: The present study included consecutive outpatients (May 1996 to April 1998) who developed allergic reactions or intolerance to tartrazine in psychotropic drugs. Total patients exposed to tartrazine-containing drugs were also recorded. The subjects showing allergic reactions to tartrazine were then exposed to non-tartrazine-containing brands. RESULTS: Of 2210 patients exposed to tartrazine-containing drugs, 83 (3.8%) developed allergic reactions. The symptoms subsided within 24 to 48 hours of stopping the drug. None of the patients showed allergy to non-tartrazine-containing brands. History of allergy to tartrazine was present in 13.2%, and 15.7% of patients had a history of aspirin sensitivity. CONCLUSION: Tartrazine allergy should be considered in patients developing drug allergy, because it would require changing the brand rather than stopping treatment with that drug.

Adolescent↗
PubMed2000

Hysterical aphonia--an analysis of 25 cases.

Hysteria is a common neurotic disorder in psychiatric practice. Many of its conversion symptoms have not been studied in detail. In the present prospective study in a tertiary care teaching hospital, 25 cases of hysterical aphonia were analysed. There were 17 females and 8 males. Mean age of presentation was 18.4 years in females and 21.2 years in males. Majority of patients were literate upto primary class, belonging to joint family and had urban background. Duration of symptoms was within 2 weeks. Most common precipitating factor was stress of examination or failure followed by quarrels with peers or spouse. In 20% cases, cause was not known. Comorbid psychiatric disorders were found in 80% cases, the most common being mixed anxiety and depressive disorder (36%) followed by generalized anxiety disorder (20%).

Adolescent↗
PubMed2000

Psychosocial dysfunction in tuberculosis patients.

Tuberculosis continues to be a major health problem in India. It carries social stigma and results in adverse psychological sequelae. In the present study, 50 patients suffering from tuberculosis were examined. There was higher degree of neuroticism and the patients with tuberculosis showed marked to severe psychosocial dysfunctioning in personal, familial, vocational, social and cognitive areas.

Adolescent↗
PubMed2000

Compulsive spitting--a culture bound symptom.

Compulsive Spitting, as a culture bound symptom has not been previously reported in the literature. Of 26 cases described, 8 were suffering from schizophrenia followed by 5 cases having mania, 4 each with depression and OCD, 3 with tic disorder and 2 with seizure disorder. More studies are warranted to study and report the culture bound symptoms in india and other countries.

Adolescent↗
PubMed1999

An analysis of 60 cases of culture bound syndromes.

Of 60 cases of culture bound syndromes seen in psychiatry OPD, Dhat syndrome was most common (76.7%), followed by possession syndrome (13.3%). Depression by the most common associated psychiatric disorder. As the data on culture bound syndromes in Indian subcontinent is less, this study calls for careful evaluation of these patients psychologically to detect and treat the associated psychiatric comorbidity appropriately.

Adolescent↗
PubMed1999

A study of P300-event related evoked potential in the patients of major depression.

Many studies involving various electrophysiological parameters have been conducted in psychiatric disorders like schizophrenia and dementia to assess their cognitive dysfunctions. Not much reports are available in major depression. The present study was conducted in 20 patients of major depression to evaluate their cognitive functions in terms of P300. P300 or P3 wave of auditory event related evoked potentials (ERPs) is usually seen around 300 msec of presenting of target stimulus, if the subject is responding to it. Auditory ERPs were recorded using the standard 'odd ball' paradigm. The latencies of various components of ERPs N1, N2, P1, P2, and P3 were recorded and compared with those of 20 normal age and sex matched controls. The latency of P300 was found to be significantly delayed in cases of major depression as compared to that of controls. Other waves were also delayed in cases of depression but the difference was not statistically significant. Our results suggest that P300 latency is longer in the patients of major depression disorders which could be due to constitutive altered 'cognitive neuronal pool' or a neurotransmitter/neuropeptide imbalance. Further studies involving larger populations are required to elucidate the diagnostic and predictive role of latency of P300 in the cases of depression.

Adult↗
PubMed1999

Munchausen's syndrome: a case report.

Munchausen syndrome, a chronic factitious disorder with physical symptoms, also called hospital hoboes or hospital addiction, is an uncommon psychiatric disorder, usually presents as an emergency. The correct recognition of the syndrome is important in medical practice. A brief review with an interesting case report is presented.

Adult↗