M S Braverman | PubMed Health

PubMed1986

Three-dimensional reconstructions of objects from serial sections using a microcomputer graphics system.

A computer graphics system for constructing 3-dimensional models of tissues from serial sections has been designed around a Motorola 68000 CPU. The system consists of a Dual Systems 16-bit microcomputer running the UNIX operating system. A Scion Corporation MicroAngelo color graphics system drives the color monitor. Three-dimensional imaging is enhanced by hidden line removal and area filling by color. A computer-drawn model of a cherry angioma is compared with a previously constructed physical model of the same angioma to illustrate how the system operates.

Computers↗

PubMed1985

An algorithm to improve the computational efficiency of genetic linkage analysis.

The computational complexity of genetic linkage analysis can increase exponentially with the square of the number of alleles at a marker locus. Many of the most informative marker loci have a large number of associated alleles. The precise identities of the alleles are irrelevant to the linkage analysis so long as identity-by-descent and linkage-phase information are preserved. This paper introduces an algorithm which, by relabeling, reduces the number of alleles at the marker locus, thereby increasing the speed of the analysis. The relabeling scheme preserves linkage-phase and identity-by-descent information so the results of the analysis are unaffected. Unlike previously published methods, this algorithm can be applied to pedigrees of arbitrary structure with both complete and incomplete phenotypic information.

Alleles↗