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Biomedical subjects

M S Cattaruzza

Publications and source records attributed to M S Cattaruzza.

10 recordsLinked to original sources

Risk factors for caesarean section in Italy: results of a multicentre study.

A recent large increase in Caesarean section (CS) in Italy was the initial stimulus for a study to identify risk factors for CS and, if possible, to suggest strategies to counteract the rise. The study was conducted in three hospitals where a wide range of individual variables was collected from the clinical records and from personal interviews. Crude CS rates and odds ratios were evaluated for each single variable while logistic regression has been used to investigate possible confounding factors. The study involved 1316 consecutive deliveries. Crude CS rates were 29.4%, 15.7% and 16.1%. Variables identified as high risk factors were pre-eclampsia, previous CS, breech and other non-vertex presentations. Antenatal care under an obstetrician working in the same hospital, a low number of antenatal consultations, previous miscarriages, offer (by obstetrician) and request (by women) for CS showed significantly high odds ratios (ORs). Previous live births was strongly negatively associated with CS. No relationship between type of delivery and social status was observed while a physician factor was detected in all three hospitals where rates for different physicians ranged from 0% to 52.8%. Apart from the main medical indications for Caesarean section (previous CS, breech presentation), the results seem to indicate that individual practice style may be an important determinant of the wide variation in the rates of Caesarean delivery. While this may have been suspected before this study, these results are the first hard data to indicate that, in Italy, CS is widely performed for non-medical reasons.

Adult

Immune response of the elderly to rabies vaccines.

A serological study has been performed to detect the antibody response to full schedules of two anti-rabies vaccines (PDEV and HDCV). Subjects aged > 50 years, compared with subjects 11-25 years, showed significantly lower titres after the 4th dose (and, to a lesser extent, after the 5th dose), suggesting that, among the elderly, the 6th dose is strongly desirable.

Adolescent

Trend of caesarean section in Italy: an examination of national data 1980-1985.

An Italian nationwide presentation of data concerning the proportion of births by caesarean section (CS) for the period 1980-1985 is presented here. A constant increase in CS was noted, from 11.2% in 1980 to 15.8% in 1985. The increase was observed in all regions while higher rates were noted in northern and central Italy. CS rates are higher in older age groups, in pregnancies from 29th to 35th week of gestation for high and low birthweights and malpresentations. Ecological associations revealed that CS is positively related to economic development and negatively to perinatal and stillbirth rates.

Adult

Indications for caesarean section: results of a local study.

Records from 6820 deliveries of three year (1980, 1985 and 1988) were reviewed in order to collect informations on cesarean section trend and its indications in a public hospital of Milan, Italy. Data show the magnitude of the phenomenon in the wards considered and an evident increase of cesarean section proportion from 1980 (18.6%) to 1988 (26.9%). The frequencies of major indications has not changed much apart from dystocia which has decreased and previous cesarean section which has increased. A logistic regression model was performed to evaluate cesarean section risk factors. Distribution of cesarean section during the days of the week show higher (about 30%) cesarean section proportion Monday through Thursday compared with low proportion (20% or less) on Fridays and weekend-days; this suggesting a possible high proportion of pre-programmed cesarean section.

Adult

Nutrition and lung cancer.

It has been suggested that protective factors might explain the differential incidence of lung cancer within a given population. Changes in diet, for example, might modulate neoplastic cell formation, since food contains many modifiers of carcinogenesis. The number of studies carried out so far does not permit to draw final conclusions yet. Interesting topics to be discussed include substances which doubtlessly play no role whatsoever for the prevention of lung cancer, like vitamin C, and those which seemingly do, like selenium. Still others consist in cholesterol, vitamins A and E, for which data are either controversial or, at present, still scanty. Moreover, the paper reviews the importance of interactions among nutrients for their effects on cancer risk. Considering major studies in this field, the review puts into evidence the principal results of research carried out so far.

Cholesterol, Dietary