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Biomedical subjects

M S Croxson

Publications and source records attributed to M S Croxson.

44 records · Page 3Linked to original sources
PubMed1975

Fetal hypothyroidism complicating medical treatment of thyrotoxicosis in pregnancy.

Two women with thyrotoxicosis were treated with antithyroid drugs during pregnancy. One women had inadvertently received a therapeutic dose of radioiodine at 21 weeks gestation and the other suffered from severe thyrotoxicosis with a serum LATS level of 1850%. In both patients, the serum triiodothyronine was maintained above 500 ng/dl by the concurrent oral administration of this hormone. Despite this precaution, cord serum thyrotrophin levels were markedly elevated and both infants showed clinical signs of hypothyroidism at birth. This experience indicates that triiodothyronine does not prevent fetal hypothyroidism when given to the mother in pharmacological amounts.

Adult↗
PubMedDate not supplied

Heterophile antibodies may cause falsely lowered serum cortisol values.

OBJECTIVE: We describe a case where interference by heterophile antibodies in a cortisol immunoassay led to a falsely lowered serum cortisol level. CASE DATA: As part of a diagnostic workup for fatigue, a 42-yr-old woman was found to have a low 9.00 h serum cortisol and an abnormal Synacthen stimulation test consistent with adrenal insufficiency. On insulin hypoglycemia testing, markedly discrepant cortisol levels were obtained from paired samples tested by two different immunoassays. Further tests, including plasma ACTH and overnight metyrapone test, confirmed normal hypothalamic-pituitary-adrenal axis function. Negative interference on the initial immunoassay from a heterophile antibody in the patient's serum was detected, thereby explaining the abnormal results. CONCLUSIONS: This report demonstrates that potentially significant consequences can arise from the failure to consider heterophile antibody interference. Clinicians who interpret test results need to be aware of the potential for interference in immunoassays by heterophile antibodies.

Adrenal Insufficiency↗