Biomedical subjects
Publications and source records attributed to M S Fletcher.
This is a report of a gastric perforation secondary to a metastasis from a primary squamous cell carcinoma of the lung in a 70-year-old white man who was being treated with cimetidine for a presumed benign gastric ulcer. The literature concerning bronchogenic carcinoma metastasizing to the stomach and small bowel is reviewed, and the effect of cimetdine on malignant gastric ulcers is discussed.
Five cases are described in which hepatic nodules discovered as an incidental finding at laparotomy performed for other reasons were thought to be metastatic tumour. In each case histology and clinical course proved this assumption to be incorrect. It is emphasized that biopsy is mandatory in such circumstances to establish the diagnosis. Where the nature of the hepatic lesion might affect the choice of operative procedure frozen section examination should be performed at the time of surgery. Bacteriological culture may also be helpful.
Partial nodular transformation is a rare condition which effects the perihilar portion of the liver and may cause chronic portal hypertension. This case report describes an elderly women in whom the condition was confined to the caudate lobe, which had become greatly enlarged and, by external compression of th portal vein at the hilum of the liver, had caused portal vein thrombosis and subsequent acute ascites.
Neoplastic autovagotomy causing atonic gastric stasis is extremely rare. Two cases are reported in which marked gastric stasis was complicated by a bezoar and a gastric volvulus respectively. Both cases were associated with a left hilar bronchial carcinoma, and malignant invasion of the vagus nerve may have been the underlying cause.