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Biomedical subjects

M S Ghouri

Publications and source records attributed to M S Ghouri.

7 recordsLinked to original sources
PubMed1984

The galvanic nature of synapse and the physicochemical aspects of nerve action.

All electrode reactions are either electrochemical oxidation or electrochemical reduction reactions and therefore membrane potentials are produced by redox reactions. Postsynaptic potentials are the result of spontaneous galvanic electrochemical changes produced by neurotransmitters. Action potentials denote microelectrolysis along the axon length. Threshold is proportional to charge and the higher the threshold the greater the potential energy. Resting membrane potential is thermodynamically controlled whereas action potential is kinetically controlled phenomenon.

Animals↗
PubMed1970

Beta-adrenoceptor stimulating properties of para-dimethylaminobenzaldehyde.

1. Studies on the various isolated tissues indicate that para-dimethylaminobenzaldehyde (DMAB) is a beta-adrenoceptor stimulant. DMAB is antagonized by the beta-adrenoceptor blocking agent, MJ 1999, but not by the alpha-adrenoceptor blocking agent, phentolamine.2. A study of dose-response relationships suggests a competitive interaction between MJ 1999 and DMAB.3. DMAB was about 122 times less potent than isoprenaline on the isolated guinea-pig tracheal preparation. The effects of DMAB on isolated rabbit atria were not only very weak, but were also very brief. On this tissue, DMAB was respectively 72,000 and 55,400 times less active than isoprenaline in producing positive chronotropic and inotropic effects. DMAB caused the relaxation of the guinea-pig taenia coli and the rabbit ileum. These actions were very weak in comparison with those of isoprenaline.4. These results suggest that a compound (DMAB) structurally different from isoprenaline may mimic isoprenaline responses by stimulating beta-adrenoceptors through different mechanisms.

Adrenergic alpha-Antagonists↗