Biomedical subjects

M S Goldman

Publications and source records attributed to M S Goldman.

At least 19 recordsLinked to original sources

PubMed2001

Global structure, robustness, and modulation of neuronal models.

The electrical characteristics of many neurons are remarkably robust in the face of changing internal and external conditions. At the same time, neurons can be highly sensitive to neuromodulators. We find correlates of this dual robustness and sensitivity in a global analysis of the structure of a conductance-based model neuron. We vary the maximal conductance parameters of the model neuron and, for each set of parameters tested, characterize the activity pattern generated by the cell as silent, tonically firing, or bursting. Within the parameter space of the five maximal conductances of the model, we find directions, representing concerted changes in multiple conductances, along which the basic pattern of neural activity does not change. In other directions, relatively small concurrent changes in a few conductances can induce transitions between these activity patterns. The global structure of the conductance-space maps implies that neuromodulators that alter a sensitive set of conductances will have powerful, and possibly state-dependent, effects. Other modulators that may have no direct impact on the activity of the neuron may nevertheless change the effects of such direct modulators via this state dependence. Some of the results and predictions arising from the model studies are replicated and verified in recordings of stomatogastric ganglion neurons using the dynamic clamp.

Action Potentials↗

PubMed2000

The usefulness of electrical stimulation for assessing pedicle screw placements.

The purpose of this study was to further establish the efficacy of pedicle screw stimulation as a monitoring technique to avoid nerve root injury during screw placement. The study population consisted of 662 patients in whom 3,409 pedicle screws were placed and tested by electrical stimulation. If stimulation resulted in a myogenic response at a stimulation intensity of 10 mA or less, the placement of the screw was inspected. Inspection was necessary for 3.9% of the screw placements in 15.4% of the study population. None of the patients in the study experienced any new postoperative neurologic deficits. These findings provide guidelines for the interpretation of stimulation data and support the use of this technique as an easy, inexpensive, and quick method to reliably assess screw placements and protecting neurological function.

Bone Screws↗

PubMed2000

The influence of alcohol expectancy priming and mood manipulation on subsequent alcohol consumption.

Studies showing that verbal priming can implicitly affect alcohol consumption have been used to support cognitive models of expectancies. However, because expectancy words reflect affective states as well as drinking outcomes, mediation through an affective pathway remains theoretically plausible (i.e., such words inadvertently may affect mood, which in turn influences drinking). The primary pathway was identified (and expectancy theory was tested) by comparing memory priming (using alcohol expectancy or neutral words) with mood induction (using positive or neutral music); an unrelated experiment paradigm allowed the priming manipulation to implicitly affect drinking. Men in the alcohol priming group drank significantly more than men in each of the other conditions, and, consistent with theory, men with histories of heavier drinking drank the most when primed with alcohol expectancies, indicating that expectancies can function as automatic memory processes.

Adult↗

PubMed2000

Validation of multidimensional scaling-based modeling of alcohol expectancies in memory: age and drinking-related differences in expectancies of children assessed as first associates.

BACKGROUND: As evidence has accumulated that alcohol expectancies mediate the effects of other drinking antecedents, attempts to understand the mechanism by which expectancies influence behavior have focused on modeling memory processes. Previous expectancy work, however, has used relatively indirect approaches to retrieve and model information stored in memory. By using the method most recommended by memory researchers for directly obtaining uncontaminated memory contents, we assessed children's expectancies and related findings to empirically modeled organization and activation of expectancies in memory based on scaled instruments. METHODS: Individual interviews were conducted with 462 children in 2nd through 5th grades, and surveys were completed by 1,003 children in 3rd, 6th, 9th, and 12th grades. Interviews and surveys consisted of a measure designed to retrieve participants' first expectancy associate to an alcohol prompt and several drinking quantity/frequency questions. RESULTS: Older and higher drinking children were more likely to report positive expectancies as their first associate to an alcohol prompt. Age and drinking-based findings were consistent with organizational structure, dimension emphasis shift, and paths of association identified by prior multidimensional scaling techniques. CONCLUSIONS: Consumption of alcohol among children corresponded to accessibility of positive expectancies in memory. In addition, the use of multidimensional scaling to study the organization and activation of alcohol expectancies in memory was validated.

Adolescent↗

PubMed2000

The culture of science and the ethics of alcohol administration in research.

The failure of ethicists to develop an absolute ethical code has led to the consideration of ethics in particular contexts. In the alcohol field, such consideration has resulted in considerable controversy, because this field has been influenced by parallel cultural contexts: a scientific research culture and a layman's spiritual culture (represented by Alcoholics Anonymous). Both cultures can inform ethical decisions, but for scientific decisions to be made the influence of these cultures must be disentangled. This article reviews issues pertaining to this disentangling in connection with the use of alcohol administration in research.

Alcoholism↗

PubMed1998

Age and drinking-related differences in the memory organization of alcohol expectancies in 3rd-, 6th-, 9th-, and 12th-grade children.

To advance the theoretical modeling of the development of alcohol expectancies as a parallel processing memory network, this study assessed expectancies and alcohol consumption of 2,324 children in Grades 3, 6, 9, and 12 from a large suburban-rural school district. Individual-differences scaling (INDSCAL), a variant of multidimensional scaling, mapped expectancies into a hypothetical memory network format, and preference mapping (PREFMAP) modeled hypothetical paths of association within this network. Throughout this age range, older and higher drinking youth appeared to associate positive and arousing effects with alcohol cues, in contrast to lower drinking children, who appeared to mainly associate undesirable effects. These drinking-related differences in the organization of expectancy information are discernible well before onset of regular drinking habits and may influence the development of drinking in adolescence.

Adolescent↗

PubMed1998

Expectancy challenge and drinking reduction: process and structure in the alcohol expectancy network.

Expectancies' mediational (control) role in alcohol consumption has been supported by both correlational and experimental evidence (J. Darkes & M. S. Goldman, 1993; M. S. Goldman, P. E. Greenbaum, & J. Darkes, 1997; L. Roehrich & M. S. Goldman, 1995). This study assigned participants (n = 54) to 1 of 2 expectancy challenges targeting the expectancy dimensions of either arousal or sociability identified by B. C. Rather and M. S. Goldman (1994), or to a no-treatment control, to examine the relationship of the structure and process of change in alcohol expectancies. Both challenges resulted in reduced consumption and expectancies immediately posttreatment and 6 weeks later after a short "booster" session. These results may reflect the lack of "discrete" expectancy structure and provide further support for the exploration of these methods as a possible prevention strategy.

Adult↗

PubMed1997

Implications of mothers' personality for their parenting and their young children's developmental outcomes.

Using a recent model (Watson, Clark, & Harkness, 1994), we examined implications of mothers' personality (N = 103) for parenting and children's developmental outcomes, using multiple personality self-reports, lengthy, repeated naturalistic observations, and mothers' reports about parenting and their child. Mothers high in negative emotionality and disagreeableness showed more negative affect and their children were more defiant and angry; they also reported more power-assertive and less nurturant parenting, as well as less secure attachment, more behavioral problems, and lower internalization of rules in their children. Mothers high in constraint and California Psychological Inventory (CPI) socialization reported more secure attachment and better internalization of rules; CPI socialization also correlated negatively with observed maternal verbal power assertion and children's defiance and anger, and positively with compliance. Regression analyses indicated that mothers' personality, particularly negative emotionality and socialization, influenced broadly conceptualized adaptive child outcomes, even after the influence of parenting was controlled.

Adult↗

PubMed1995

Expectancy for social facilitation from drinking: the divergent paths of high-expectancy and low-expectancy adolescents.

Using a 3-wave longitudinal design, adolescents were studied over a 2-year period during which many first began to drink. Covariance structure modeling showed that teens' expectancy for social facilitation from alcohol and their drinking experience influenced each other in a reciprocal, positive feedback fashion: the greater the expectancy endorsement, the higher subsequent drinking levels, and the higher the drinking levels, the greater the subsequent expectancy endorsement. This model fit the data quite well; comparison models, in which expectancy (or drinking) had no independent influence on future drinking (or expectancy), showed significantly poorer fit than the present model. Initial nondrinkers' social expectancy predicted individual differences in the rate of drinking increase over the 2 years. Results bolster the hypothesis that expectancy actively influences drinking and point to the importance of expectancy-based intervention efforts.

Adolescent↗

PubMed1995

Self-reported drinking and alcohol-related problems among early adolescents: dimensionality and validity over 24 months.

OBJECTIVE: Researchers rely on adolescents' self-reports of alcohol consumption and alcohol-related problems, despite little evidence concerning their validity. We assessed the reliability and validity of adolescents' self-reports, employing collateral validation and focusing on the understudied transitional years of early adolescence. METHOD: Subjects were 214 boys and 247 girls who participated in school-wide surveys that assessed drinking, drunkenness and alcohol-related problems each year for 3 years. These measures were validated by collateral (peer) reports and by separate, 7-day drinking calenders. Internal consistency and test-retest reliability were also assessed. RESULTS: Results replicated findings with older adolescents that drinking/drunkenness and alcohol-related problems fall on two partially overlapping dimensions. Scales assessing each dimension had moderate to high internal consistency and high test-retest stability. Correlations with collateral reports were relatively strong for the drinking/drunkenness scale, moderate for a dichotomous variable reflecting the presence or absence of alcohol-related problems, and more modest for the alcohol-related problems scale. Correlations with diary reports of drinking behavior were strong for drinking/drunkenness. Results generally replicated across gender and over time. CONCLUSIONS: Researchers can have some confidence in the reliability and validity of early adolescents' survey self-reports, particularly of alcohol consumption (alcohol-related problems occurred with low base rates, perhaps limiting validity coefficients). Because drinking/drunkenness and alcohol-related problems shared 30% of their variance, factors other than consumption (e.g., personality factors) apparently influenced the experience of alcohol-related problems.

Adolescent↗

PubMed1995

Cortical petechial hemorrhage, leukoencephalopathy, and subacute dementia associated with seizures due to cerebral amyloid angiopathy.

Although cerebral amyloid angiopathy is a well-known cause of cerebral lobar hemorrhage, subacute dementia, seizures, and acute encephalopathy without lobar hemorrhage are infrequently recognized as manifestations of this disease. In this report, we describe a case of cerebral amyloid angiopathy in a 74-year-old woman who had subacute progressive dementia and a superimposed rapid acute neurologic deterioration associated with seizures and the presence of cerebral edema on computed tomographic scans and leukoencephalopathy and cortical petechial hemorrhages on magnetic resonance imaging. A diagnosis of cerebral amyloid angiopathy in conjunction with small cortical infarcts and petechial hemorrhages was confirmed by antemortem biopsy. This clinical and radiologic picture is being increasingly recognized as characteristic of cerebral amyloid angiopathy.

Aged↗

PubMed1994

Covariance structure models of expectancy.

Antecedent variables under the broad categories of genetic, environmental and cultural influences have been linked to the risk for alcohol abuse. Such risk factors have not been shown to result in high correlations with alcohol consumption and leave unclear an understanding of the mechanism by which these variables lead to increased risk. This study employed covariance structure modeling to examine the mediational influence of stored information in memory about alcohol, alcohol expectancies in relation to two biologically and environmentally driven antecedent variables, family history of alcohol abuse and a sensation-seeking temperament in a college population. We also examined the effect of criterion contamination on the relationship between sensation-seeking and alcohol consumption. Results indicated that alcohol expectancy acts as a significant, partial mediator of the relationship between sensation-seeking and consumption, that family history of alcohol abuse is not related to drinking outcome and that overlap in items on sensation-seeking and alcohol consumption measures may falsely inflate their relationship.

Adaptation, Psychological↗

PubMed1993

Expectancy challenge and drinking reduction: experimental evidence for a mediational process.

Substantial correlational evidence supports a causal (mediational) interpretation of alcohol expectancy operation, but definitive support requires a true experimental test. Thus, moderately to heavily drinking male college students were randomly assigned to 1 of 3 conditions in a pre-post design: Expectancy challenge (designed to manipulate expectancy levels), "traditional" information, and assessment-only control. Expectancy challenge produced significant drinking decreases, compared with the other 2 groups. Decreases in measured expectancies paralleled drinking decreases in the challenge condition. Significant increases in alcohol knowledge in the traditional program were not associated with decreased drinking. These experimental findings support a causal (mediational) interpretation of expectancy operation. The implications for a cognitive (memory) model of expectancies and for prevention and intervention programs for problem drinking and alcoholism are discussed.

Adult↗

PubMed1993

Experience-dependent neuropsychological recovery and the treatment of alcoholism.

Accumulating research has shown that some cognitive deficits in recently abstinent alcoholics (e.g., cognitive flexibility, acquisition of novel skills) improve only with remediation in contrast to the spontaneous, time-dependent rebound seen for other tasks. In principle, this facilitated or experience-dependent recovery should enhance acquisition of the content of alcoholism treatment programs, but this relationship has yet to be tested empirically; previous research assessed recovery using only neuropsychological tasks presented by an experimenter. The current investigation focused on treatment-relevant remediation (acquisition of the content of a relapse-prevention [RP] program) using tasks administered by self-guided workbooks. Four groups of male alcoholics received pre- and posttesting. Between the two testing sessions, the groups received neuropsychological remediation tasks (n = 15), ecologically relevant tasks (n = 15), attention-placebo tasks (n = 16), or no intervention (n = 15). Results showed that exposure to both types of remediation produced significant cognitive recovery, with skills transferring to posttest neuropsychological measures and RP acquisition. Hence, cognitive remediation may facilitate alcoholism treatment.

Adult↗

PubMed1992

Empirical modeling of an alcohol expectancy memory network using multidimensional scaling.

Risk-related antecedent variables can be linked to later alcohol consumption by memory processes, and alcohol expectancies may be one relevant memory content. To advance research in this area, it would be useful to apply current memory models such as semantic network theory to explain drinking decision processes. We used multidimensional scaling (MDS) to empirically model a preliminary alcohol expectancy semantic network, from which a theoretical account of drinking decision making was generated. Subanalyses (PREFMAP) showed how individuals with differing alcohol consumption histories may have had different association pathways within the expectancy network. These pathways may have, in turn influenced future drinking levels and behaviors while the person was under the influence of alcohol. All individuals associated positive/prosocial effects with drinking, but heavier drinkers indicated arousing effects as their highest probability associates, whereas light drinkers expected sedation. An important early step in this MDS modeling process is the determination of iso-meaning expectancy adjective groups, which correspond to theoretical network nodes.

Adolescent↗

PubMed1992

Stereotactic thalamotomy for medically intractable essential tremor.

Objective surgical symptomatic outcome of ventrolateral (VL) thalamotomy specifically for essential tremor is uncommonly reported and functional outcome has not been investigated previously. In the present series, 7 patients underwent unilateral and 1 patient staged bilateral VL thalamotomies for disabling medically refractory essential tremor. At follow-up examination (mean 17.3 months, range 1-50 months), all patients enjoyed complete ablation or significant amelioration of the targeted tremor. Disability as determined by a modified form of an established rating scale for tremor was reduced from moderate (57%) or severe (43%) to absent (86%) or mild (14%). Interestingly, voice tremor was ablated or significantly improved in 71.4% of patients with preoperative voice tremor.

Follow-Up Studies↗

PubMed1992

Personality and spirituality: comparative TATs of high-achieving Rajneeshees.

The Thematic Apperception Test (TAT) was administered to followers of Bhagwan Shree Rajneesh in their commune in central Oregon. The Rajneeshee subjects had been high achievers (with advanced degrees and/or previous incomes greater than 30,000 dollars in 1984 dollars). Later, TATs were administered to persons matched for gender, age, education, and occupation but not involved in new religions. The final matched sample included 24 men and 20 women, half of whom were Rajneeshees. TATs were coded for a variety of formal variables as well as personality ratings. Though the analysis showed no between-group differences on most variables, significant mean differences occurred on ratings of unusual conditions, quest, and narcissism, with Rajneeshees higher than comparison subjects. Gender differences in personality variables were not conspicuous. Factor analysis established a strong productivity element. Card 16 (the blank card) provided the greatest number of differences.

Journal Article↗

PubMed1992

The symptomatic and functional outcome of stereotactic thalamotomy for medically intractable essential tremor.

Eight patients with medically refractory disabling essential tremor underwent ventralis lateralis (VL) thalamotomies; the procedure was unilateral in seven cases and bilateral (staged) in the other. Contralateral tremor remained absent or markedly reduced in all patients at the time of the most recent follow-up examinations, at a mean of 17.3 months after surgery. Disability was determined by a modified form of an established rating scale for tremor, and was reduced from a mean score of 21.1 (moderate grade) to 3.9 (absent grade) (p less than 0.001). Interestingly, voice tremor was abolished or significantly improved in 71.4% of patients with preoperative voice tremor. This feature has not been reported previously. Persistent surgical morbidity was limited to two patients with mild dysarthria and one with a mild cognitive impairment. There were no surgically related deaths. It is concluded that stereotactic VL thalamotomy is a treatment option for medically intractable disabling essential tremor.

Adolescent↗