PubMed Health⌕ Search

Biomedical subjects

M S Goncharenko

Publications and source records attributed to M S Goncharenko.

At least 19 recordsLinked to original sources
PubMed1993

Energy metabolism of human erythrocytes in psoriasis.

1. Adenine nucleotide concentrations and metabolism in red blood cells (RBC) and RBC ghosts from psoriatic patients and healthy subjects were compared. 2. The ATP and total adenine nucleotide levels and the adenylate energy charge (EC) were elevated in the blood from psoriatic patients. 3. The rate of glycolytic production of ATP by intact RBC was unchanged, but the Na+, K(+)-ATPase activity of RBC ghosts was decreased significantly in psoriasis. 4. Results suggest that the defect in adenine nucleotide metabolism is a systemic manifestation of psoriasis, and that the quantification of adenine nucleotides in RBC and in whole blood samples may be of pathophysiological value in psoriatic lesion.

Adenine Nucleotides↗
PubMed1992

[Differentiation, electrically stimulated nuclear motility and ultrastructure of buccal epithelial cells from normal people and psoriatic patients].

The comparative analysis of cell differentiation, ultrastructure and volt-stimulated cell nuclear motility was made on buccal epithelium scraped from normal persons and psoriatic patients. About 70% of cells in normal epithelium were classified as cells of the 5th differentiation stage. The same percent of cells exhibited the stimulated nuclear motility. In buccal epithelium of psoriatic patients 54% of cells belonged to the 4th differentiation stage, but ultrastructurally they were of the 3-5th differentiation stages. In epithelial cells of psoriatic patients only 25% of cells were classified as the 5th differentiation stage and 34% of cells had nuclear motility. Their percent increased by 60 when 10(-7) M adrenaline was added in vitro. The results allow conclusion that the nuclear motility is characteristic of degraded epithelial cells with defective tonofilamentous cytoskeleton but with retained electrochemical K(+)-potential.

Cell Differentiation↗
PubMed1990

[A mathematical model of membrane ion transport in psoriasis].

The authors discuss the problems related to mathematical simulation of ionic transport via cellular membrane and to identification of such models as exemplified by calcium metabolism. The examined model adequately reflects the characteristic features of the time course of ion transport in various stages of psoriasis, this permitting the use of this model in mathematical solving of the problem of optimal treatment of psoriasis patients. Graphs and results of estimations made with personal IBM-compatible computer are presented.

Biological Transport↗
PubMed1989

[A statement on the mathematical tasks of optimization in dermatology].

The authors set forth the theoretical basis for the introduction of optimal management mathematical methods into clinical practice. Purely medical problems and those borderline with applied mathematics have been investigated. Recommendations on the choice of a purposeful functional system of differential equations describing physiological processes over the disease course, initial conditions, and restriction system are given. This helps plan the methods for and course of the clinical examinations and come closer to the creation of mathematical and program background for the problem of optimal management of dermatologic diseases treatment.

Arthritis, Psoriatic↗
PubMed1989

[The protein spectrum of human erythrocyte membranes in normal conditions and in psoriasis].

Analysis of human erythrocytic membrane protein spectrum in psoriasis patients has shown that psoriasis-associated shifts in the quantitative composition of protein fractions are characterized by a decrease of the spectrin band by 21% and an increase of the protein band 4 by 32%. The detected changes in the protein spectrum of psoriasis patients may be an indicator of the red cell cytoskeleton impairment associated with this condition.

Adult↗
PubMed1989

[Disordered calcium metabolism in Reiter's disease].

Cellular (erythrocytic) and extracellular (blood serum) calcium levels have been measured in patients with Reiter's disease and with urogenital chlamydiosis over the course of treatment. Calcium metabolism disorders depending on the disease severity have been detected in chlamydiosis patients. Calcium homeostasis imbalance manifests as a significant rise of the red cell calcium level in the presence of normal Ca ion concentration in the blood serum, which fact may result from impaired Ca ion transport through the plasma membrane. Combined therapy, including erythromycin, resulted, besides Chlamydia elimination, in normalization of Ca metabolism parameters under study.

Adolescent↗