PubMed HealthSearch

Biomedical subjects

M S Halliday

Publications and source records attributed to M S Halliday.

6 recordsLinked to original sources

Speech, "inner speech," and the development of short-term memory: effects of picture labeling on recall.

Three experiments explored the effect of overt speech on children's use of "inner speech' in short-term memory (STM). Experiments 1 and 2 compared recall of a series of pictured objects when 5- and 11-year-olds either labeled stimuli at presentation or remained silent. Use of inner speech was assessed by manipulating word length of the picture names (Experiment 1) or phonemic similarity (Experiment 2). Word length and phonemic similarity had greater effects in the older children and when pictures were labeled at presentation. These tendencies were such that 5-year-olds were sensitive to word length and phonemic similarity only with labeling. Experiment 3 compared labeling by the child with labeling by the experimenter in 5-year-olds. There were no significant differences with respect to overall performance or effects of word length and phonemic similarity. It is suggested that speaking or listening to speech activates and internal "articulatory loop,' and that such activation is especially important when the child's ability to use inner speech in STM has not fully developed.

Attention

Pharmacokinetic and pharmacodynamic interaction between the antidepressant tianeptine and oxazepam at steady-state.

To assess if any pharmacokinetic or pharmacodynamic interaction at steady-state occurs between the new antidepressant tianeptine and a benzodiazepine (oxazepam) following multiple oral dosing of both drugs, 12 healthy male volunteers entered a balanced three-way double blind cross-over study. Tianeptine (12.5 mg) and/or oxazepam (10 mg) were given three times daily for 4 days. Pharmacokinetic data within a dosing interval at steady-state showed that there were no statistically significant changes in the pharmacokinetics of either tianeptine (and its two major metabolites) or oxazepam when both drugs were co-administered. Psychometric data showed that there was no synergistic negative interaction between the two drugs and that their combination may result in beneficial effects on "alertness" and "happiness".

Adult

Disinhibition and spontaneous recovery of response decrements produced by free reinforcement in rats.

Spontaneous recovery and disinhibition were studied in 3 experiments in which, after rats had been trained to bar press on a variable interval schedule of reinforcement, response rates were reduced by the introduction either of extinction or of a response-independent (free) reinforcement schedule. Spontaneous recovery was consistently obtained in extinction, especially when session durations were long. Under free reinforcement conditions there was little sign of spontaneous recovery, even when with high reinforcement rates response reduction was almost as rapid as in extinction. In disinhibition tests the introduction of noise produced increased responding under free reinforcement conditions, but not in extinction. The results are interpreted as demonstrating a dissociation between spontaneous recovery and disinhibition.

Animals