Biomedical subjects

M S Hausman

Publications and source records attributed to M S Hausman.

3 recordsLinked to original sources

PubMed1976

Abnormal monocyte function in bladder cancer patients.

We evaluated 39 patients with various stages of bladder carcinoma to determine alterations in monocyte function. Since the monocyte plays an important role in the effector arm of the immune system defective function may explain the host's inability to destroy neoplastic cells. As a group these 39 patients demonstrated defective monocyte monocyte function. There was no correlation between tumor stage and degree of chemotactic defect. Patients with invasive carcinoma had a significant return of monocyte chemotactic response toward normal postoperatively (p less than 0.005). Monocyte function was improved also in 3 patients who received Bacillus Calmette-Guerin immunotherapy (p less than 0.05).

BCG Vaccine↗

PubMed1975

Defective monocyte function in patients with genitourinary carcinoma.

An assay allowing quantitation of monocyte function, i.e., chemotaxis, was used to study the activity of monocytes in patients with neoplasms of the urinary tract. Twenty-four subjects with various stages of renal carcinoma exhibited a mean chemotactic defect of 34% (P less than 0.005) as compared to normal controls and patients hospitalized with nonneoplastic diseases. Twelve persons with transitional cell carcinoma of the bladder had a 29.8% (P less than 0.01) mean chemotactic defect as compared to the controls. There was no correlation between tumor stage and degree of chemotactic defect;--J Natl Cancer Inst 55: 1047-1054, 1975.

Adenocarcinoma↗

PubMed1975

The effects of BCG on the dog bladder.

Immunostimulation with agents such as Bacillus Calmette-Guérin (BCG) may represent an adjunctive treatment modality in patients with cancer of the bladder. To investigate the effects of direct inoculation, BCG was injected into the bladder of sensitized (PPD) and nonsensitized dogs. A marked and predictable inflammatory reaction was seen in all of the sensitized and in some of the nonsensitized dogs. This reaction was characterized by an extensive histiocytic infiltration with varying proportions of polymorphonuclear leukocytes, plasma cells, and lymphocytes. Follow-up examination of one dog 7 weeks after initial biopsy showed that this marked inflammatory reaction had resolved. Our findings suggest that in the future nonspecific immunopotentiators may play a role in the treatment of cancer of the bladder.

Animals↗