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Biomedical subjects

M S Hsi

Publications and source records attributed to M S Hsi.

At least 19 recordsLinked to original sources
PubMed1995

Epilepsy and intracranial meningiomas.

BACKGROUND: Only a few studies have reflected the incidence and causes of preoperative and postoperative seizures in meningiomas. This study concerned the incidence and types of preoperative epilepsy, and the predisposing factors for postoperative epilepsy in meningiomas. METHODS: Epilepsy occurred in 323 surgically treated intracranial meningiomas. The focus here is different types of seizures, tumor locations, onset of seizures and the histopathological features of the meningiomas. RESULTS: From analysis of 323 patients with intracranial meningiomas, aged 10 to 79, 98 (30.3%) were found to have different types of preoperative epilepsy; in 32 (32.7%) of them, the seizures persisted postoperatively. Among 225 patients without preoperative seizures, 39 (17.3%) developed postoperative seizures. Thus, a history of preoperative seizures is a significant index (p < 0.005) for predicting the occurrence of postoperative seizures. In a total of 71 patients with postoperative seizures, the precipitating factors in the first week were cerebral edema and hemorrhage at the surgical sites. In late postoperative seizures (onset beyond one week post-surgery), the main cause was tumor recurrence. Patients with sagittal and convexity meningiomas had a higher incidence of seizures. There is no relationship between the histopathological features of the tumor and the occurrence of epilepsy in meningiomas. CONCLUSIONS: There is a significant incidence of postoperative seizures in meningioma patients with a history of preoperative seizures. Surgical excision of tumor, absence of postoperative hemorrhage or edema and anticonvulsant therapy reduced the occurrence of postoperative seizures.

Adolescent↗
PubMed1995

[Community-based cervical cancer screening in seven townships in Taiwan].

Cervical cancer is the leading malignant neoplasm in women in Taiwan. In order to compare the validity of various cervical neoplasia screening methods, estimate the prevalence of low- and high-grade squamous intraepithelial lesions (LSIL and HSIL), and identify risk factors for LSIL and HSIL, a community-based cervical neoplasia screening program was implemented in Sanchi, Chutung, Potzu, Kaohsu, Makung, Huhsi, and Paihsa townships, Taiwan. Both cervical smears and cervicograms were used for the screening of cervical neoplasia. Subjects who had positive cervical smears, cervicogram, or both, were further confirmed by colposcopy-guided biopsy. A total of 10,628 married women aged 30 to 64 years were recruited from seven study townships which gave a response rate of 25.2%. Among 667 subjects who screened positive, 555 (82%) underwent colposcopy-guided biopsy. The age-adjusted prevalence was 3.4% for LSIL and 1.7% for HSIL. The biopsy-confirmed rates for cervical smear-detected LSIL and HSIL were 62.8% and 80.6%, respectively; while 56.6% of minor lesions and 22.2% of major lesions identified by cervicogram were biopsy-confirmed as LSIL and HSIL, respectively. The sensitivity of detecting LSIL was higher for cervicograms (79.3%) than for cervical smears (16.7%), and cervicograms had a lower sensitivity in detecting HSIL (48.4%) than cervical smears (90.0%). Multiple logistic regression analysis showed a striking geographical variation in prevalence of LSIL and HSIL. The prevalence of LSIL decreased with the increase in age, and increased with the duration of taking oral contraceptives. The prevalence of HSIL increased with the parity and the duration of taking oral contraceptives and was also significantly associated with the history of cervical cancer among mother and sisters. It is suggested that improvements in the participation rate of cervical neoplasia screening would promote women's health in Taiwan.

Adult↗
PubMed1993

Overlapping syndrome of MERRF and MELAS: molecular and neuroradiological studies.

We describe a 42-year-old woman with overlapping syndrome of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes) and MERRF (myoclonus epilepsy and ragged-red fibers). Clinically, she had episodic headache, stroke-like episode with left hemiparesis and lactic acidosis commonly found in MELAS syndrome. However, myoclonus seizure, and ataxia with dyssynergic gait characteristic of MERRF were also noted. Computed tomographic scans showed a right temporo-parietal hypodense lesion. The lesion disappeared 20 months later, even magnetic resonance images also failed to reveal this abnormality. A molecular analysis of mitochondrial DNA was conducted by using restriction endonucleases ApaI and NaeI. A transition from A to G was found at the nucleotide position 3243, but not found at the 8344th nucleotide pair. In this report, we document the fluctuating CT changes and emphasize the importance of molecular analysis in patients with overlapping syndrome of mitochondrial encephalomyopathies.

Adult↗
PubMed1992

Hypothalamic amenorrhea in a case of mitochondrial encephalomyopathy.

A 26-year-old female with myoclonus epilepsy associated with ragged-red fibers is reported. Clinically, she had myoclonus epilepsy, cerebellar ataxia, a bilateral neurosensory type hearing loss, retinitis pigmentosa and short stature. She also presented with primary amenorrhea and poor development of secondary sexual characteristics. Endocrinologic studies revealed that hypothalamic dysfunction was the most plausible cause of her primary amenorrhea. Magnetic resonance imaging showed marked dilatation of the third ventricle indicating thalamic and hypothalamic degeneration. We conclude that hypothalamic dysfunction may be one of the characteristic features of mitochondrial encephalomyopathies.

Adult↗
PubMed1989

Nocardial cerebral abscess: report of a case.

Cerebral nocardiosis is an uncommon disease which has not been previously reported in Taiwan. We describe a 70-years-old man who, known to have a history of rectal cancer, developed a cerebral nocardial abscess. The patient was admitted with a week history of gradual weakness of the left limbs. There was neither fever nor headache. Neurological examination disclosed left hemiparesis. Computed tomography of the brain revealed a decreased density in the right parietal region with a ring enhancement. Biopsy of the cerebral lesion showed Nocardia asteroides.

Aged↗
PubMed1987

Cerebral arteriovenous malformation: report of 136 Chinese patients in Taiwan.

The authors studied 136 Chinese patients with verified cerebral arteriovenous malformations (AVMs) in Taiwan. Intracranial hemorrhage (ICH) was the leading problem at presentation (83.8%), followed by epileptic seizures (21.3%) and vascular headache alone (9.6%). Patients less than forty years old and/or with small AVMs (less than 20 ml) had a statistically significantly higher risk of bleeding (P less than 0.01 and P less than 0.05 respectively). The risk of rebleeding remained unchanged in both small (less than 20 ml) and large (greater than or equal to 20 ml) AVMs once ICH had occurred. The average annual bleeding rate of a nonbleed AVM with seizure alone was 1.7%. Seizures with a partial component could be identified in less than half of the epileptic patients, and EEG abnormalities were found in 85.7% of 45 studied cases. The difference in mortality between medically and surgically treated patients was not of statistical significance. The numbers for both morbidity and good recovery were higher in the surgical group. The rationale for selection of surgical cases is discussed.

Adult↗
PubMed1983

Syndrome of polyneuropathy, skin hyperpigmentation, oedema and hepatosplenomegaly.

Four middle-aged male Chinese with polyneuropathy, skin hyperpigmentation, oedema, hepatosplenomegaly, ascites, gynaecomastia and white nails are described. In Japan and United States this syndrome has been associated with plasma cell dyscrasia. However, neither M-protein nor skeletal lesions were demonstrated in these four patients.

Adult↗