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Biomedical subjects

M S Ignatova

Publications and source records attributed to M S Ignatova.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Heredity and diseases of the organs of the urinary system: results and prospects of research].

The paper deals with current ideas of the role played by heredity in the development of diseases of the urinary system organs (USO). Hereditary nephropathies are divided into groups of disorders associated with chromosome aberrations (0.28 percent), monogen-inherited pathology (13 percent), multifactorial or polygen-inherited pathology (86.72 percent). Hereditary predisposition associated with antigenic determinants of the HIA system, immune, metabolic, histological defects and other factors are implicated in the development of multifactorial diseases. The pathways by which the disease predisposition is realized are nonuniform. There prospect well novel biotechnological approaches, virologic, pharmacogenetic studies aimed at understanding of the role of heredity in the development of USO disorders, at diagnosing borderline illnesses, and at preventing the disease manifestations.

Child↗
PubMed1989

[Features of thrombophilia in nephrotic syndrome in children].

A comprehensive study was made of the hemostatic system in 25 children with the nephrotic syndrome and combined forms of glomerulonephritis. Hypercoagulation and a number of factors preventing thrombosis formation were revealed, namely the presence of so-called thrombin-resistant blocked fibrinogen, a rise of the total antithrombin potential at the expense of proteins differing from antithrombin III, sufficient reserves of plasminogen, and a moderate increase of fibrin degradation products.

Antithrombin III↗
PubMed1989

[Health status of children born to women with renal pathology].

The children born to mothers suffering from glomerulonephritis, pyelonephritis and hereditary nephritis were followed up for 4-5 and more years. This allowed a conclusion about a considerable rate of the birth of children with pathology of the urinary system organs (USO) and with diseases of other organs which were diagnosed for the first time at the age of 3-10 years as a result of goal-oriented investigations. The groups of the children born to women with renal diseases were marked by a high perinatal lethality studied by means of retrospective questionnaire. As for the structure of the USO diseases, the children manifested the predominance of the disease patterns associated with dysembryogenesis at the organ (anatomic abnormalities), tissue (dysplasia of the renal tissue) and at the cellular levels (metabolic nephropathies). In children born to women with hereditary nephritis, USO pathology was of the same kind and occurred only in the form of hereditary nephritis, which corresponds to the concepts of monogenously inherited pathology. The demonstration during pregnancy of a considerable rate of the environmental effects capable of exerting a damaging action on the embryonal development of children born to women with glomerulo- and pyelonephritis suggests a concomitant genesis of USO diseases in children born to mothers suffering from renal diseases. The authors discuss measures aimed at the prevention or reduction of the incidence of USO pathology in children as well as at the recognition of pathologies in children born to women with renal diseases at the predisease stage.

Child, Preschool↗
PubMed1989

[Course and outcome of nephropathies of structural renal dysembryogenesis].

The authors elucidate the role played by structural renal dysembryogenesis in the development, progress and outcome of nephropathies. Based on an analysis of mainly morphobiopsies of the kidneys in 298 patients aged 2.5 to 15 years a high incidence of renal dysembryogenesis is shown as an independent disease entity and as combined with acquired nephropathies. This provides basis for regarding structural deficiency of the kidneys as predisposing factor to the development of immune or microbial inflammation. The long-term (up to 18 years) observation over children with the most frequently occurring variant of renal dysembryogenesis, hypoplastic dysplasia, made it possible to define the main clinico-laboratory characteristics and outcome of the pathology determined by a high rate of the formation of chronic renal failure.

Adolescent↗