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Biomedical subjects

M S Jung

Publications and source records attributed to M S Jung.

4 recordsLinked to original sources
PubMed2006

Effects of velocity gradient and mixing time on particle growth in a rapid mixing tank.

Effects of velocity gradient (G value) and mixing time (t) on the coagulation of particles were investigated by monitoring particle counts in a rapid mixing process. Total particle counts after mixing of 30 s at G value of 200 s(-1) were similar to the summation of clay particles and alum precipitates at alum dose of 30 mg L(-1). Although small particles (microflocs less than 5 microm) were formed within the mixing time of 30 s, macroflocs larger than 8 microm did not increase significantly until the mixing time of 60 s. However, macroflocs larger than 8 microm started to increase after mixing of 75 s and they reached the maximum counts at 150 s. On the other hand, macroflocs larger than 8 microm decreased after mixing time of 180 s due in breaks of the macroflocs, which resulted in resuspension of small particles. The rapid mixing conditions for the maximum growth of macroflocs were the G value of 200 s(-1) and the mixing time of 150 s, which confirmed the best performance of turbidity removal in jar tests. Growth and break of particles and flocs in a rapid mixing step would influence significantly on the sequential flocculation and sedimentation processes for turbidity removal.

Alum Compounds↗
PubMed2001

p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor.

Recent studies have identified two p53 homologues, p63 and p73. They activate p53-responsive promoters and induce apoptosis when overexpressed in certain human tumors. Here, we report that p63, like p53 and p73, induces replicative senescence when expressed in a tetracycline-regulated manner in EJ cells lacking a functional p53. In addition to transcription activation of p53-responsive genes, we found that p63 and p73 repress transcription of the cdk1 and cyclin B genes, both of which are irreversibly repressed in senescent human fibroblast. In transient transfection assay, p63 and p73 repress the cdk1 promoter regardless of the presence of a dominant negative mutant form of p53. Furthermore, we found that DNA binding activity of NF-Y transcription factor, which is essential for transcription of the cdk1 and cyclin B genes and inactivated in senescent fibroblast, is significantly decreased by expression of either of p53, p63, or p73. Since NF-Y binds to many promoters besides the cdk1 and cyclin B promoters, inactivation of NF-Y by p53 family genes may be a general mechanism for transcription repression in replicative senescence.

CCAAT-Binding Factor↗
PubMed1988

[A study for assessing accuracy rates of pain rating scales (KPRS and VAS)].

The purpose of this study was to identify the accuracy rates(hit ratio) which mean the degree of concordance between pain rating scale differences over time & subjective comparisons. Subjective comparisons mean the responses to the question "how does the pain you are now experiencing compare with the one at the time of the assessment yesterday?". Answers to this question were translated into 'greater', 'same', or 'less'. KPRS (Korean Pain Rating Scale) was developed through 4 consecutive studies to assess pain extensively & accurately by Lee etc. VAS (Visual Analogue Scale) was reported as valid & reliable measure for the intensity of pain by many researchers. Thirty hospitalized patients with complaints of headache participated in this study during the period from May 1 to July 31, 1987. In conclusion, the accuracy rates of KPRS and VAS were 60%, 67%, respectively.

Humans↗