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Biomedical subjects

M S Keshavan

Publications and source records attributed to M S Keshavan.

At least 127 records · Page 7Linked to original sources
PubMed1986

Phobias in India and the United Kingdom. A trans-cultural study.

Thirty-nine phobic patients from India were compared with 39 similarly diagnosed age and sex matched patients from the United Kingdom. The British sample contained significantly more patients with agoraphobia and social phobia compared to the Indian group. Sudden death and illness phobias were more frequent in the Indian group. The Indian phobic patients also had more somatic and depressive symptoms. The influence of culture on the presentation of different phobias is discussed.

Agoraphobia↗
PubMed1986

Improvement of phencyclidine-associated psychosis with ECT.

Phencyclidine-associated psychosis may mimic classic forms of both schizophrenia and affective psychosis. Treatment of phencyclidine-associated psychosis may prove very difficult for some patients. A patient who developed a severe phencyclidine-associated psychosis and failed to respond to high doses of antipsychotics is described. The patient responded dramatically to electroconvulsive therapy.

Adult↗
PubMed1986

"On-off" phenomena and manic-depressive mood shifts: case report.

A patient with idiopathic Parkinson's disease and "on-off" phenomena is described. A consistent relationship existed between the "on" (dyskinetic) phases and mania and between the "off" (akinetic) phases and depression. The heuristic interest of this case and its indirect support of the dopamine hypothesis of affective disorder are discussed.

Adult↗
PubMed1984

TSH-response patterns to TRH stimulation may indicate therapeutic mechanisms of antidepressant and neuroleptic drugs.

The study was designed to investigate, by weekly thyrotropin-releasing hormone tests, possible patterns of thyroid-stimulating hormone (TSH) responses which may indicate therapeutic mechanisms of antidepressant and neuroleptic drugs in patients with depressive and paranoid-hallucinatory syndrome during their process of recovery (3-9 weeks). 65 depressed women and 33 paranoid-hallucinatory women have been studied while on antidepressant (clomipramine) or neuroleptic (haloperidol) treatment, respectively. Four patterns of TSH response were observed. Patients with a pattern of a 'disblunting TSH response' (normalization of an abnormal low response) during drug treatment had a significantly higher chance to recover compared to patients with other TSH response patterns. This finding was independent of psychopathological features and drugs used for treatment. A hypothesis of 'malactivation' as a pathogenetic indicator of various psychotic states is being presented.

Adult↗
PubMed1981

Convulsive threshold in humans and rats and magnetic field changes: observations during total solar eclipse.

Convulsive thresholds were measured in 26 psychiatric patients who were receiving electroconvulsive treatment, and in 8 rats subjects to electroconvulsive shocks, during the recent the recent total solar eclipse day (February 16th, 1980) and on control days. Our results showed that there was a significant reduction in the convulsive thresholds of both humans and rats at the time of solar eclipse, probably occurring due to the observed geomagnetic field variation of 19 Gammas.

Animals↗
PubMed1981

Post-traumatic psychiatric disturbances: patterns and predictors of outcome.

A prospective follow-up study of 60 randomly selected cases of closed adult civilian head injuries was conducted for three months from the time of head injury to assess the frequency, patterns, and factors related to post-traumatic psychiatric disturbances. Eighty per cent of the cases had a neuropsychiatric disturbance as assessed at 1 1/2 months. The commonest was post-concussional syndrome (43 per cent). The extent of social dysfunction was directly related to the severity of head injury. However, the total number of symptoms (largely subjective) correlated highly with pre-traumatic neuroticism. The inter-relatedness of organic and personality factors in the post-traumatic syndrome, and their predictive value, are discussed.

Adolescent↗
PubMed1980

I11-defined somatic symptoms in a South Indian rural clinic. Some preliminary clinical observations.

A detailed physical and psychiatric examination was carried out on 125 patients presenting with vague illdefined sensory symptoms, at a South Indian rural primary care clinic. Among these 94 cases were found to have a predominantly sensory peripheral neuropathy, 19 cases had evidence of other medical illnesses, and only 12 cases could be categorised as being functional. The large number of cases of peripheral neuropathy in a South Indian village is probably nutritional and resembles the clinical pattern of the burning feet syndrome. The significance of the presentation of these cases with vague somatic and psychological symptoms to psychiatric epidemiology is stressed.

Adult↗
PubMedDate not supplied

Electroencephalographic sleep in schizophrenia: a critical review.

Several polysomnographic abnormalities seem to occur consistently in schizophrenic patients: impaired sleep continuity and reduced total sleep, reduced amounts of slow wave sleep, and reduced rapid eye movement (REM) sleep latency and defective REM rebound following REM deprivation. None of these findings is specific for schizophrenia, and only a subgroup of schizophrenic patients seem to have these abnormalities. It appears that reduced slow wave sleep may be related to a neurodevelopmental disorder related to the defect state in schizophrenia. The pathophysiological significance of the defective REM rebound and the REM sleep abnormalities in schizophrenia remain uncertain. Carefully designed studies are needed to further characterize the sleep disturbance in schizophrenia and to study them in relation to other, known pathophysiological changes in this disorder.

Cerebral Cortex↗