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Biomedical subjects

M S Komandenko

Publications and source records attributed to M S Komandenko.

13 recordsLinked to original sources
PubMed1991

[Use of partusisten in prevention of hyperkalemia in patients with chronic glomerulonephritis with initial forms of renal failure].

The studies performed proved the ability of the drug partusisten (in a dose of 10 mg/day) to effectively reduce an elevated potassium level in the serum of chronic sufferers with glomerulonephritis and initial renal insufficiency. Normal concentrations of Ca, K and Na in relevant patients remained unchanged except a slight rise in K urinary excretion this suggesting an extrarenal mechanism of K redistribution consequent to the action of beta 2-adrenergic agents.

Adult↗
PubMed1991

[The ability of partusisten to improve kidney excretory function in the initial stage of kidney failure in patients with chronic glomerulonephritis].

To assess the effect of partusisten (fenoterol) on excretory function of the kidneys, the drug was administered per os in a dose of 10 mg/day for 7-10 days in 17 chronic glomerulonephritis patients with initial forms (stages I-IIA) of renal failure. A dramatic increase of glomerular filtration, a certain rise of tubular reabsorption, a reduction of blood concentration of nitrous residues were revealed, which was accompanied by electrolyte shifts and hemodynamic changes characteristic of partusisten. It is concluded that partusisten can be used as a drug ameliorating excretory function of the kidneys in chronic glomerulonephritis patients with initial forms of chronic renal failure.

Adolescent↗
PubMed1991

[Once more about interstitial nephritis].

A comparative study was made of 25 patients (Group 2, control) with documented pyelonephritis and 55 patients (Group 1) who had a morphological picture of chronic interstitial inflammation without signs of abnormal urodynamics, bacteriuria, urographic and sonographic evidence of pyelonephritis. All the patients underwent life-time morphological study, their immunological spectrum (IgA, IgG, IgM, IgE) was explored. They had a test for sensitization of a peripheral blood mononuclear fraction to one or several drugs which had been given to the patients. The patients from Group 1 displayed significantly elevated IgE levels and a regularly detected sensitization of mononuclears to one or several drugs. Morphologically, there were signs of congenital renal tissue dysplasia in the presence of diffuse interstitial inflammation. Positive immunofluorescence findings were seen in the tubular wall of 10 (18%) patients. The findings made it possible to define diagnostic criteria for interstitial nephritis, a nosological entity.

Adult↗
PubMed1991

[Mechanisms of tubulo-interstitial tissue lesions of the kidneys in chronic glomerulonephritis].

The paper is concerned with a study into the mechanisms of renal interstitial lesions of the secondary character seen in patients afflicted with chronic glomerulonephritis. 120 patients with mesangioproliferative and membranous proliferative glomerulonephritis were examined. The patients were distributed into groups depending on the disease acuity, the degree of glomerular sclerosis and the disease stage. Three major mechanisms of the augmentation of changes in the renal interstice have been revealed: 1) exacerbation of the underlying process; 2) the degree of fibroplastic and sclerotic lesions in the glomerulus; 3) drug sensitization.

Adult↗
PubMed1989

[Mechanisms of the development of drug-induced nephropathy].

A hypothesis of the development of drug-induced nephropathy has been reviewed. The authors believe that the body sensitization to different drugs underlies drug-induced nephropathy. The sensitization may develop in the presence of congenital or acquired abnormalities leading to hemodynamic disorders in the kidneys.

Adult↗
PubMed1988

[Etiology of tubulointerstitial nephritis].

Clinicomorphological manifestations of little-known forms of tubulointerstitial nephritis (TIN) are described. TIN development is considered in persons on prolonged antispasmodic therapy for epilepsy, in patients with HBS-antigen against a background of chronic hepatitis or liver cirrhosis, and in persons with chronic glomerulo- or pyelonephritis.

Biopsy, Needle↗
PubMedDate not supplied

[Criteria for the early diagnosis of chronic kidney failure].

Comprehensive study of blood and urinary levels of beta 2-microglobulin and cAMP in patients with chronic renal failure (CRF) demonstrated their significant alterations in the disease development. Therefore the levels of beta 2-microglobulin and cAMP could be of great aid in reaching the early diagnosis of CRF.

Adolescent↗
PubMedDate not supplied

[The mechanisms of the development of arterial hypertension in patients with chronic kidney failure treated by hemodialysis].

Hypertensive patients out of 50 with chronic renal failure degree IIIA on programmed hemodialysis were divided into those with uncontrolled (group 1) and controlled (group 2) arterial hypertension. Group 1 was found to have hyperactive renin-angiotensin aldosterone system and marked unbalance in the system of cyclic nucleotides. In group 2 the activity of renin and plasma aldosterone levels were not so high. In both groups the above hormonal abnormalities followed the pattern of progressive hyperkinetic syndrome running with an inadequate fall in peripheral vascular resistance responsible for arterial hypertension in these patients.

Adult↗