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Biomedical subjects

M S Lakshmi

Publications and source records attributed to M S Lakshmi.

At least 37 records · Page 2Linked to original sources
PubMed1977

Does dexamethasone inhibit the growth of human gliomas?

Dexamethasone (10-(4)M) was shown to inhibit the growth of human gliomas in culture. This was indicated by the inhibition of incorporation of radioactively labeled thymidine into the deoxyribonucleic acid (DNA) of the cells, and by the increase in the generation time of cells exposed to the drug in vitro. On the other hand, tumors obtained from patients who had received dexamethasone before craniotomy grew considerably faster in vitro than tumors from patients who had not been given the drug before operation.

Astrocytoma↗
PubMed1975

Tumour-associated surface antigen(s) in human astrocytomas.

The cytotoxic properties of a hetero-antiserum have been used to demonstrate surface antigen(s) common to seven human astrocytomas. This has been designated human astrocytoma-associated antigen (HAAA). Tissue cultures of astrocytomas were prepared. A rabbit antiserum was raised to one of these and its antibody activity on the original tumour cells assayed by dye exclusion cytotoxicity testing. After repeated absorption with associated antigen(s). In a series of absorption experiments, HAAA was detected in six other human astrocytoma cultures, but not found in a series of other human tumours and tissues tested. Homogenates of two original astrocytomas absorbed out HAAA activity in a similar way indicating the presence of the antigen(s) in vivo. The significance of this HAAA is discussed.

Antigens, Neoplasm↗