Biomedical subjects
Publications and source records attributed to M S Lea.
Saphena varix is a rare condition characterized by isolated distention of the saphenous vein immediately below the sapheno-femoral junction. The clinical significance of saphena varix lies in its differentiation from other conditions that cause a groin mass. A case of saphena varix is presented and methods for differentiating this unusual condition from other causes of groin masses are discussed.
Our data support the contention that biliary bypass combined with gastric bypass is the treatment of choice for the majority of patients with adenocarcinoma of the pancreas. Compared with resection, operative morbidity and mortality rates were lower, length of hospitalization was shorter, and the cost of treatment was lower. There was no significant difference in survival. In choosing candidates for resection, the surgeon must balance the meager chances for cure (less than 1 percent) with the considerable operative hazard and the risk of lethal, costly complications. In our view, resection should be considered only for physiologically young patients with small localized lesions. These patients should be referred to surgeons specializing in pancreatic surgery who have had operative mortality rates of less than 10 percent. Pancreatic resection must, therefore, be deprived of its appeal as a procedure to which every surgeon must aspire.
We quantified natural variation in maximum aerobic capacity (V02max) exhibited by a free-living population of bullfrogs (Rana catesbeiana) and examined the degree to which such variation is associated with key parameters of the systemic oxygen transport apparatus and oxidative enzyme (citrate synthase) activity at the tissue level. Regression analysis of these data revealed that only ventricle mass and hemoglobin concentration accounted for significant fractions of the variation in V02max. Neither variation in maximum heart rate nor in citrate synthase activity were significantly correlated with individual variation in maximum aerobic capacity. These results support the contention that, in at least some taxa, maximum aerobic capacity is limited by the ability of the cardiovascular system to deliver oxygen to the tissues.
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