Agglutination, gel precipitation and immunoelectrophoresis demonstrated the presence of antigens common for human malignant tumors of different sites and BCG and Listeria monocytogenic microorganisms. The radioimmunoassay of sera in the agglutination test showed that these sera reacted with tumor cells rather than with cells from normal human tissues. The common antigen had the electrophorectic mobility in the beta-globulin zone.

Agglutination Tests↗

PubMed1980

[Antigenic and immunosuppressive properties of the aniotic fluid (an experimental study)].

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Amniotic Fluid↗

PubMed1980

[Thermo-stable tumor-associated antigens in the serum of tumor-bearing animals and in tissue cultures of malignant tumors].

Gel precipitation and immunoelectrophoresis have demonstrated the presence of thermostable tumour-associated antigens in blood serum from tumour-bearing rats and culture supernatant of malignant cells. These antigens have the electrophoretic mobility in the zones of beta-, alpha- and alpha 1-globulins.

9,10-Dimethyl-1,2-benzanthracene↗

PubMed1978

[Thermostable antigens of malignant tumors and normal tissues of experimental animals].

Gel precipitation and immunoelectrophoresis tests tests demonstrated the presence of thermostable antigens in dimethylbenzanthracene-induced malignant tumours of the muscle tissues of Wistar rats. These antigens were relatively tissue-specific for the tumours, amniotic fluid and the uterus on the one hand, and for the lung, spleen, and the serum on the other hand. The thermostable antigens of the tumours and the amniotic fluid had the electrophoretic mobility in the zone of alpha and alpha1-globulins.

9,10-Dimethyl-1,2-benzanthracene↗

PubMed1977

[Serum factors that inhibit in vitro immunological reactions in malignant tumor development in experimental animals].

In two immunological reactions (immunocytoadherence and inhibition of macrophage adherence in the presence of specific antigens) it was shown that autologous and homologous native sera in some percentage of cases render an inhibitory effect. One of the blocking factors of sera proved to be rather thermostable, the other, on the contrary, to be thermolable.

Animals↗

PubMed1977

[Antigens common to Mycobacterium bovis (BTsZh) and several malignant and normal tissues of laboratory animals].

Agglutination, gel precipitation and immunoelectrophoresis tests demonstrated the presence of antigens common for the Mycobacterium bovis (BCG) and some malignant and normal rat tissue cells. The method of absorption of immune sera in the agglutination test showed that this antigen was specific for the BCG microorganisms and cells of primary induced tumours of rat muscle tissue. This antigen had the electrophoretic mobility in the beta-globulin zone.

Adenofibroma↗

PubMed1975

[A blocking factor in normal animal sera inhibiting immunologic reactions in vitro].

An extremely thermostable and resistant to some chemical substances factor was found in the sera of Wistar and noninbred rats of different age, male and female. This factor inhibited the action of normal and immune antibodies to rat erythrocytes and rat serum antigens. The blocking factor was relatively specific and more effective in respect to the normal antibodies than to the immune ones. The activity of the blocking factor was connected with the alpha1-globulin.

Age Factors↗

PubMed1975

[Immunologic responses of the body to tumors induced by DMBA].

As a result of the complex immunobiological study in an autologous system on the models of DMBA induced tumors in muscular tissue there were shown 3 types of cell response to primary tumors, their metastases and autotransplantation: no response, moderate and very pronounced reaction. In a definite percentage of cases autologous peritoneal macrophages were found to inhibit malignant cells in autotransplantation. The percentage of positive inoculations and an average weight of transplants of primary tumors and their metastases at the moment of highest transplantation immunity (12-14 days) have been definitely correlated with the intensity of cell response developed in these tissue, and also are dependent on individual features of proper malignant cells.

9,10-Dimethyl-1,2-benzanthracene↗

PubMed1970