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Biomedical subjects

M S Mandelcorn

Publications and source records attributed to M S Mandelcorn.

At least 19 recordsLinked to original sources
PubMed1993

Surgical removal of subretinal hemorrhage and choroidal neovascular membranes in acute hemorrhagic age-related macular degeneration.

The visual prognosis in patients with age-related macular degeneration in whom an acute extensive subretinal hemorrhage develops involving the centre of the fovea is extremely poor. We report our results in seven consecutive patients with acute hemorrhagic age-related macular degeneration who underwent pars plana vitrectomy with internal drainage of blood lying beneath the retina and the retinal pigment epithelium. In three of the patients subretinal choroidal neovascular membranes were also removed. Five patients, including three of the four who underwent surgery within 2 weeks of the onset of symptoms, had improved vision following surgery, in one patient choroidal neovascularization recurred, and one patient experienced no change in vision. The best results were obtained in the four patients who did not undergo deliberate dissection of choroidal neovascular membranes.

Acute Disease↗
PubMed1983

Preretinal membranectomy in idiopathic preretinal macular fibrosis.

Idiopathic preretinal macular fibrosis (PMF) rarely causes progressive loss of vision. In 5 of 350 cases in which vision did markedly diminish, pars plana vitrectomy and membranectomy proved to be a useful surgical method of correcting the visual loss. There was an apparent recurrence of PMF in two of the five cases.

Adult↗
PubMed1978

Computed axial tomography localization of intra-orbital foreign body.

Conventional radiographs in a patient with an intra-orbital foreign body showed that it was close to the back of the globe. Computed axial tomography showed that it lay beside a swollen and probably lacerated optic nerve. The advantages of CT scanning in the investigation of intra-orbital foreign bodies are outlined.

Adult↗
PubMed1977

Results after vitrectomy in trauma.

We report the results of vitrectomy in 15 consecutive cases of ocular trauma operated on during one year. The cases are divided into three groups according to whether the main damage involved the anterior, posterior, or anterior segments. Of the 15 cases two thirds had a successful outcome. A penetrating injury and total retinal detachment with massive preretinal retraction were two features associated with poor results.

Adolescent↗
PubMed1977

Epi-macular holes: a cause of decreased vision in the elderly.

The development of epi-macular holes in the elderly represent a maculopathy which resembles senile macular hole and surface wrinkling retinopathy. Clinically it is most likely a sub-type of surface wrinkling retinopathy in which a hole forms in the epi-macular membranes. The findings in 11 patients with this condition are described.

Adult↗
PubMed1976

Pars plana vitrectomy for the management of sever diabetic retinopathy.

In 100 severely diseased diabetic eyes we performed pars plana vitrectomy. After a median follow-up time of seven months, major visual improvement was achieved in 49% of the eyes. An additional four eyes maintained a preoperatively good visual acuity resulting in an overall success rate of 53%. Eyes with only vitreous hemorrhages did better (71%) than eyes with posterior retinal detachments (31%). We did not observe new tissue proliferation in any of the operated eyes.

Cataract Extraction↗
PubMed1975

Proliferation and metaplasia of intravitreal retinal pigment epithelium cell autotransplants.

Pigment epithelium cells autotransplanted into the vitreous cavity of owl monkey eyes, proliferated and metaplased. The metaplastic cells looked like pigmented macrophages, membrane forming fibrocyte-like cells, and frank epithelium cells. This in vivo experiment demonstrated that the vitreous cavity is an adequate culture medium for cells deriving from the pigment epithelium and that pigment epithelium cells could be the source of intraocular proliferation seen in massive periretinal proliferation.

Animals↗
PubMed1975

Membrane formation by autotransplanted retinal pigment epithelium (RPE).

Autotransplanted RPE cells after free intravitreal injection or in millipore diffusion chambers placed into the vitreous cavity undergo metaplasia: they first show the characteristics of macrophages. Later they transform into spindle-shaped cells or even into pigment epithelium-like cells. The latter two cell types have definite epithelial cell characteristics, such as cellunctions and basement membrane formation, clearly indicating that they are of ectodermal origin. These results support the hypothesis that RPE proliferation and metaplsia may play a major role in the formation of collagen-containing membranes, such as are found in massive periretinal proliferation (MPP).

Animals↗