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Biomedical subjects

M S Marques

Publications and source records attributed to M S Marques.

13 recordsLinked to original sources
PubMed1998

[A correct and an augmented medical act].

The author describes a correct medical procedure and what may be called an augmented medical procedure. Reference is made to some of the formal and material conditions and bases of clinical deliberation. It is shown why one should reread Hippocrates, Aristotle and other physicians and philosophers who considered these issues. Thus the author reviews the principles and practices that made humanity and created clinical medicine. The casuistic model of the medical procedure is compared to the so-called model of medicine based on fact. This paper provides a clear position on the value and significance of individual responsibility.

Ethics, Medical↗
PubMed1996

Biologically active flavonoids and terpenoids from Egletes viscosa.

The steam volatile components from the hexane extract of dried flower buds of Egletes viscosa were identified by gas chromatography-mass spectrometry as trans-carvyl acetate, cis-carvyl acetate, sabinyl acetate, verbenyl acetate, cyclopentaethylidene, geranyl acetate and 5-methylfuranone, and trans-pinocarvyl acetate (major component). From the non-volatile residue, centipedic acid and a novel clerodane diterpene, 12-acetoxy-hawtriwaic acid lactone, were isolated. From the ethanol extract, ternatin (4',5-dihidroxy-3,3',7,8-tetramethoxyflavone), was isolated. Ternatin showed anti-inflammatory, hepatoprotection and gastroprotection properties, and, according to the NCI protocols, it showed moderate activity against HIV. The diterpenes showed antispasmodic activity. Structure determination of these secondary metabolites was accomplished by spectrometric methods, including 2D NMR, chemical interconversion and X-ray crystallographic analysis.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1992

Allergic contact dermatitis in children. A multicenter study of the Portuguese Contact Dermatitis Group (GPEDC).

The authors report a study of allergic contact dermatitis in 329 Portuguese children of 14 years or younger. 170 children (64 male and 106 female) reacted to 1 or more allergens. Most of these were in the 11-14 years group. The main allergens were nickel, thimerosal, cobalt, mercury, fragrance-mix and potassium dichromate. Nickel reactivity predominated in females over the whole group, but a greater number of males younger than 5 years reacted to nickel. The number of positive reactions increased with age, but this was not accompained by an increase in the % of relevant tests. 12 children, all of them 13 or 14 years-old, had an occupational allergic contact dermatitis.

Adolescent↗
PubMed1989

[Anthracycline cardiotoxicity. Review of the literature and presentation of a study protocol].

Anthracyclines are drugs with widespread applications on the chemotherapy of cancer. Cardiotoxicity is an important side effect of these drugs, well known for doxorubicin, the most representative of this group of drugs. Dysrhythmias and heart failure are the most important among the toxic effects of anthracyclines and are dependent on cumulative doses reason why WHO established maximal doses for the different anthracyclines. Pathogenic hypothesis about the mechanism of the myocardial lesion induced by anthracyclines include the production of free oxygen radicals, alterations of energetic metabolism and disturbances of calcium and sodium exchange at membrane level. Early detection of the toxicity of these drugs is of utmost importance. Electrocardiography has low sensitivity and specificity. Echocardiography gives specific information about previous cardiac pathology and enables the detection of complication of the basic neoplastic disease. However, detection of early changes of left ventricular function is not accomplished so well, as it is with equilibrium radionuclide angiography. Left ventricular ejection fraction is the method of choice in the early detection of cardiotoxicity of these drugs, and its frequent evaluation enables to individualize the doses in each patient, and so, a most accurate use of the therapeutic potential of the anthracyclines. Radionuclide angiography has some important indications on the selection of patients for treatment with anthracyclines, namely: to identify patients that must be excluded from the treatment; select patients at risk of congestive heart failure; to decide the appropriate moment to stop the drugs; change the therapeutic schema, etc.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1986

[Carcinoma cuniculatum of the hand].

We've made a brief account of Carcinoma Cuniculatum and after reviewing the references, we found four cases which didn't appear on the foot as usual. We've reported a 68-year-old man, with a lesion on the back of his left hand; it had been present six years and had recurred after a surgical excision. On the clinical point of view, the lesion is a roughly oval 7 X 5 cm., plaque formed by the junction of small violaceous nodules. The surface is keratotic and it presents multiple sinuses from where a white, greasy material oozed out. Concerning the pathological findings we can observe that the papillomatous surface squamous epithelium penetrated into the underlying tissue. The epithelium contained sinuses which were filled with keratin. Occasionally the epithelium showed individual cell keratinization. The squamous epithelium was well differentiated and a feature seen was intra-cellular oedema, with sheets of uniform, pale, staining epithelium. Mitotic activity was low and confined to the basal layers. The tumour was accompanied by a fibrous stroma which was somewhere heavily infiltrated by chronic inflammatory cells. The treatment consisted of a wide excision and graft. As to the aetiology of the tumour the different authors suggest several possibilities, since the enduring trauma, chronic inflammation, burn scars, radiation, arsenic ingestion until the viral aetiology. McKee and Wilkinson suggest that it's a multifactorial process, playing the wart virus the main part in the breaking out of the tumour.

Aged↗
PubMed1985

Paget's disease of the nipple. Clinical and pathological review of 109 female patients.

The most relevant literature concerning Paget's disease of the breast is reviewed. A clinical and pathological study of female patients with Paget's disease of the breast observed during 30 years at the Lisbon 'Instituto Português de Oncologia' is carried out and its results are discussed. The low incidence of the disease in this series, when compared with those described in the available literature, is pointed out. The absence of a relation between the type of the cutaneous lesions and the histological type of the underlying tumor is emphasized. The similarity of the microscopical aspects, whichever the histological type of the underlying tumor, is considered. The differences in the clinical behavior of the tumors, related to their histological types, and the differences in respect to age, menarch, menopause, breast feeding, primary lesion and percentage of adenopathies observed between patients with and without a palpable mass, are enumerated. The authors conclude that the cure rate after 5 years is lower in patients with palpable tumors and adenopathies and in the cases with onset before menopause. The cure rate also decreases in relation to the histological type of the underlying tumor.

Adult↗
PubMedDate not supplied

Growth of a leguminous tree (Centrolobium tomentosum Guill. ex Benth.) inoculated with Rhizobium and mycorrhizal fungi.

Leguminous trees are being suggested for revegetation programs due to their ability to develop associations with rhizobia and mycorrhizal fungi. The growth of a native species of the Tropical Atlantic Forest, Centrolobium tomentosum, was evaluated in a native forest soil and in a Eucalyptus forest soil under different treatments of inoculation. C. tomentosum produced more biomass under nursery conditions after inoculation with Rhizobium BHICB-Ab1 associated with arbuscular mycorrhizal (AM). This treatment improved shoot and root growth and nodule weight under forest soil condition, while in eucalyptus soil only shoot biomass and nodule weight were significantly modified. In another experiment, using forest soil, height and stem diameter were also increased by dual inoculation procedures. The height and diameter growth promoting effect was observed when BHICB-Ab1 was used as inoculant associated with AM, but not with BHICB-Ab1 alone. In contrast, plants inoculated with BHICB-Ab3 alone were similar in height and diameter growth, to those which were inoculated with BHICB-Ab3 associated with AM. These results suggest that benefits of dual inoculation depend on triparty symbiosis and especially on the choice of Rhizobium strain.

Biomass↗