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Biomedical subjects

M S Martin

Publications and source records attributed to M S Martin.

82 records · Page 5Linked to original sources
PubMedDate not supplied

[Immunologic results obtained with an experimental system oftransplantable colonic tumors. Possible applications of these results to human intestinal tumors].

Intestinal cancers, morphologically very close to human colo-rectal adeno-carcinoma, have been induced by dimethylhydrazine in inbred rats. Graftable lines have been obtained from 5 primary intestinal tumors, and 3 cell lines have been cultivated from the grafts. This model was used to demonstrate carcinofetal antigen(s) on the surface of the intestinal cancer cells. Circulating antibodies against tumor-associated antigen(s) have been found in tumor-bearing rats. Cancer enhancement was regularly observed when specific (tumor cells) and non-specific (B.C.G.) immunologic treatments were used to prevent or cure rat intestinal tumors. These results suggest that immunotherapy of human colo-rectal cancer might be hazardous.

Adenocarcinoma, Mucinous↗
PubMedDate not supplied

Use of a specific monoclonal antibody for studying the liver metastatic invasion of a rat colon cancer.

A simple model for liver metastasis from colon cancer resulted from the intraportal injection of 2 x 10(7) highly tumorigenic DHD/K12/PROb cells into syngeneic BDIX rats. Early detection and development of cancer invasion were studied by conventional microscopy and immunoenzymatic staining using a specific monoclonal antibody. Metastases developed either from isolated cancer cells early disseminated in sinusoid network or from intraportal microthrombi. An intense immune reaction developed until day 15 after injection but decreased and disappeared at the latest stages of evolution.

Animals↗
PubMedDate not supplied

[Immunotherapy of chemically induced rat colon cancer].

An experimental model of chemically induced or transplanted rat colon carcinoma has been used to test the effects of specific (cancer cells) or non specific (BCG) immunotherapy. According to the immunization technique and schedule experiemnts resulted in a partial inhibition or definite enhancement of tumour growth. These experimental data emphasize the possible hazards of human colon cancer immunotherapy.

Animals↗
PubMedDate not supplied

Bioelectrical impedance as a discriminator of pressure ulcer risk.

In an effort to identify objective measures of tissue structure and function associated with pressure ulcer risk, bioelectrical impedance analysis (BIA) was measured in three progressively larger zones over the trochanter and coccyx in patients assessed at high risk for pressure ulcers (HR group) and age-matched normal controls (CONT group). Local BIA measures were significantly lower in the HR group for each individual site and zone (p < .01). Full-thickness tissue biopsies obtained from each measurement zone did not differ between groups. However, additional nutritional and metabolic parameters were significantly different (p < or = .05). These results suggest that local BIA may be useful in assessing pressure ulcer risk.

Aged↗
PubMedDate not supplied

Clinically significant gastroesophageal reflux in the at-risk premature neonate: relation to cognitive scores, days in the NICU, and total hospital charges.

OBJECTIVE: The principal objective of this retrospective, cohort study was to determine if clinically significant gastroesophageal reflux (GER) would impair the long-term cognitive and motor development of preterm infants. An additional objective was to determine the effects of clinically significant GER on the length of hospital stay and total hospital charges in preterm infants. STUDY DESIGN: The design was a retrospective, cohort study of 66 preterm infants, followed in the Neonatal Developmental Follow-Up Clinic of The Children's Hospital in Greenville, SC. Thirty-three premature infants with clinically significant GER met the following study criteria: birth dates, 1988 through 1994; lack of gastrointestinal anatomic defects; and lack of acute neurologic injury (defined as no intraventricular hemorrhage greater than Papile's grade I, no periventricular leukomalacia, no seizures, and no history of birth asphyxia). Clinically significant GER was defined as GER associated with moderate to severe apnea (n=29) or GER associated with moderate to severe feeding intolerance (n=4). The study patients were matched as closely as possible with 33 control premature infants for sex (except when twins were used), ethnicity, social risk, gestational age, birth weight, and Apgar scores at 1 and 5 minutes. Social risk was categorized using Hack's Social Risk Scale. Important covariates included apnea, home monitoring, and nasal continuous positive airway pressure. RESULTS: Neurodevelopmental test scores from 7 months of age through 2 years of age did not show any significant differences between premature infants with clinically significant GER and premature infants with no evidence of clinically significant GER. Total hospital charges were statistically different for the clinically significant GER infants and the nonclinically significant GER infants (median $112,916 versus median $63,928, p=0.01). Total neonatal intensive care unit length of stay measures were statistically different between the two groups (median 53 days versus median 40.5 days, p=0.01). CONCLUSION: Even though clinically significant GER may pose a substantial medical risk in premature infants, the long-term cognitive consequences appear to be negligible. Nevertheless, those premature infants with clinically significant GER do consume significantly more hospital resources than matched controls. Early diagnosis and intervention may possibly lessen the impact of medical costs and reduce length of hospital stay.

Cognition Disorders↗