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Biomedical subjects

M S Mathews

Publications and source records attributed to M S Mathews.

25 records · Page 2Linked to original sources
PubMed1993

Effect of malathion, estradiol-17-beta and progesterone on ascorbic acid metabolism in prenatal rats and their pups.

The effects of prenatal exposure to 13.78 mg, 27.56 mg or 82.6 mg malathion/100 g body weight po from 6-13 d of gestation, to 1 microgram estradiol-17-beta/d/100g body weight or 4 mg progesterone/d/100 g body weight sc from 3-20 d of gestation, or to their various combinations on brain acetylcholinesterase activity and ascorbic acid metabolism were investigated in rat dams and pups. Brain acetylcholinesterase activity was taken as an index of toxicity. Significant inhibition of acetylcholinesterase from malathion exposure was further exaggerated by estradiol-17-beta, but was reversed by progesterone. Significant increases of ascorbic acid levels and L-gulonolactone oxidase was observed with malathion toxicity. Estradiol-17-beta decreased ascorbic acid levels and stimulated dehydroascorbatase, while progesterone had no significant effect on ascorbic acid levels or on enzyme activities.

Acetylcholinesterase↗
PubMedDate not supplied

Nosocomial zygomycotic post-surgical necrotizing fasciitis in a healthy adult caused by Apophysomyces elegans in south India.

Necrotizing fasciitis caused by the zygomycete Apophysomyces elegans of the anterior abdominal wall of a young healthy woman following a lower segment caesarean section is reported. Early clinical diagnosis and laboratory identification followed by appropriate management involving extensive tissue debridement and adequate doses of amphotericin B were eventually successful in controlling the infection and saving her life.

Adult↗
PubMedDate not supplied

Chronic meningitis caused by Trichosporon beigelii in India.

A 36-year-old woman developed fatal meningitis following a myelogram. Trichosporon beigelii could be grown from the cerebrospinal fluid (CSF) on two occasions. This represents the first culture-proven case of meningitis due to Trichosporon beigelii.

Adult↗
PubMedDate not supplied

Emerging importance of Pneumocystis carinii among indian immunosuppressed patients.

Pneumocystis carinii is known to cause both significant morbidity and mortality in immunosuppressed individuals. In a six and a half year period starting with 1992, a total of 204 samples including bronchial aspirates, induced sputum and suction catheter tips were examined for P. carinii by direct microscopic examination of Giemsa's and toluidine 'O' stained smears. At a later stage of the investigation, immunofluorescent staining using monoclonal reagent (Meriflour, USA) was also used for examination of the specimens. In all 24 (11.8%) of 204 samples were positive for P. carinii. In addition, Pneumocystis carinii pneumonia (PCP) was diagnosed in five (33%) of 15 patients of acquired immunodeficiency syndrome (AIDS) with opportunistic infections. All these 15 patients had CD4 T cell counts of less than 500 T lymphocyte equivalent (TLE) /ml as measured by a Trax ELISA assay. Laboratories in India have to be better equipped for an early and correct diagnosis of PCP that is bound to rise with the increase in the number and variety of immunosuppressed patients.

Enzyme-Linked Immunosorbent Assay↗
PubMedDate not supplied

Keratitis due to Cephaliophora irregularis Thaxter.

The second case of mycotic keratitis due to Cephaliophora irregularis is reported in a 55-year-old female from India. Clinically this fungus was resistant to treatment with oral ketoconazole but responded to topical natamycin.

Antifungal Agents↗