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Biomedical subjects

M S Mihailovici

Publications and source records attributed to M S Mihailovici.

26 records · Page 2Linked to original sources
PubMedDate not supplied

Gastrin cells in stomach and duodenal ulcers.

By means of cytochemical and electron microscopy methods, the behavior of gastrin cells in ulcers of the stomach and duodenum were investigated. The study was performed on specimens of surgical resection from stomach and duodenal ulcers with gastric normacidity. The results point out a significant decrease of gastrin cells in stomach ulcers in comparison with the duodenal ones. These findings in stomach ulcers were attributed to the high intensity of gastritis lesions, histopathologically evidenced. Electron microscopy revealed that gastrin cells were loaded with secretion granules presenting suggestive images of synthesis activity.

Duodenal Ulcer↗
PubMedDate not supplied

Histochemical and histopathological liver aspects during pneumocystosis.

124 liver fragments taken on autopsy from children presenting pneumocystosis in the final stage were histochemically and histopathologically studied. There were predominantly metabolic disturbances (albuminous degeneration and fatty changes of hepatocytes) and reduced inflammatory cell infiltrates. Histochemically there were revealed three types of reticulin networks: reactivity of glycolipoproteins, of glycoproteins and fuchsinophilia. It was possible to establish a correlation between these three types of networks and the liver histological lesions. The utility of liver histopathological examination for the estimation of clinical prognosis and for treatment is pointed out.

Adipose Tissue↗
PubMedDate not supplied

[Liver transplantation. I. Its history. The indications. Clinical efficacy].

The aim of this study is to present the actual indications of the liver transplantation in adult as well as in children patients. A multicenter comparative study based on the already published reports in Europe and in the United States has been done in order to analyse the survival rates for different liver diseases subjected to liver transplantation, as well as the prevalence of these nosologic entities in different hepato-biliary centers. Such an analysis is badly needed in Romania, where the prevalence of liver diseases is relatively high, and in the context of the initiation of transplantation in our country.

Adult↗
PubMedDate not supplied

An immunohistochemical study of P53 protein on colorectal carcinomas.

AIMS: To investigate the frequency of immunohistochemical expression of p53 protein in colorectal carcinomas; to evaluate the correlation between p53 alterations and the histopathological parameters; to determine the prognostic significance of this tumor marker. PATIENT POPULATIONS: Fourty patients with colorectal carcinomas. METHODS: Paraffin embedded normal and tumoral tissues, stained, with HES, PAS, PAS-Alcian Blue stains. For detecting the p53 protein, a three step (streptavidin-biotin immunoperoxidase) immunohistochemical method was used. RESULTS: 28 out of 40 (70%) colorectal carcinomas were positive for p53. The identification of nuclear accumulations of p53 protein in the present study was significantly correlated with the anatomic site and tumor stage. CONCLUSIONS: The mutational pattern observed in this study was substantially as expected. The p53 overexpression is present in advanced stage, thus demonstrating the prognostic value of this marker.

Adenocarcinoma↗
PubMedDate not supplied

Flow-cytometry DNA index of colorectal carcinomas.

The authors investigated the relationship between flow cytometric DNA index (D.I.-defined as the ratio of the DNA content of malignant cells to that of normal cells) and other prognostic factors (grade, stage of the disease, anatomical site, patients' sex and age) of 20 patients with colorectal cancer. The entire material was obtained from 20 unselected and previously untreated patients. This material consists of fresh tumoural or normal tissues taken after radical colectomy for the flow-cytometric analysis. A normal diploid DNA content was found in six tumours, the other fourteen being founded to be aneuploid. All non malignant tissue samples showed normal diploid DNA content. In the current series of cases we have found that DI was significantly associated with stage but not with grade, anatomical site or other prognostic factors. Our data indicates that cytometrically evaluated DI values have probably an independent predictive power for the clinical outcome of colorectal cancer patients.

Adult↗