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Biomedical subjects

M S Park

Publications and source records attributed to M S Park.

At least 19 recordsLinked to original sources
PubMed1979

HLA-DRW4 in 91% of Jewish pemphigus vulgaris patients.

HLA-DRW4 was found in all 11 female and 10 out of 12 male Jewish patients with pemphigus vulgaris, a frequency of 91% in all, which was significantly higher than the 25% frequency among normal Jewish controls. The relative risk was 31.5. The BW38-DRW4 haplotype occurred in 12 out of 22 patients (55%) but in only 2% of White non-Jews and 11% of normal Jewish people.

California↗
PubMed1979

Genetic susceptibility to multiple sclerosis.

Previous studies of histocompatibility (HLA) types in multiple sclerosis (MS) families did not provide convincing proof of an HLA-linked susceptibility factor. In 12 families we studied, all MS cases in each family shared at least one chromosome. The probability of this occurring in the absence of genetic linkage is approximately 0.001. The estimated penetrance is 5 percent, implying that the genetic susceptibility factor may be a necessary but not a sufficient cause of MS. Additional studies are needed to identify other differences between affected and unaffected susceptible individuals.

Female↗
PubMed1979

HLA types and immunity in multiple sclerosis.

HLA types and levels of humoral and cell-mediated immune responses to several antigens were studied in a large group of patients with multiple sclerosis, and in controls. Patients were more likely than controls to have the DRw2 antigen. They had higher mean antibody titers to measles but not to cytomegalovirus, herpes 1, or herpes 2, and had less competent cell-mediated responses. Antibody titers to measles were lower and cell-mediated immune responses were more effective in patients with the DRw2 antigen in patients than in patients without it. This apparent specificity for measles suggests that the etiology of multiple sclerosis is related to the immune response to measles or related viruses.

Antibodies, Viral↗
PubMed1979

Dilutions and specificity analysis of pretransplant sera.

Six serial dilutions of 51 sera from pretransplant patients were reacted against T and B lymphocytes at 5 degrees C and 37 degrees C. By the use of defined panels of T and B lymphocytes it could be shown that 10% of the 51 positive sera contained T-warm antibodies against HLA-A, -B, and -C specificities. There were 28% of the sera that had antibodies against non-HLA antigens reactive to B lymphocytes in the cold. Other sera contained mixtures of HLA and non-HLA antibodies. By dilution analysis of the sera, the mixtures could be detected and the HLA specificities identified. This ability to distinguish between HLA and non-HLA antibodies should be important in classifying pretransplant patients into high- and low-risk patients. Prior evidence that we have presented suggests that the non-HLA antibodies may be enhancing antibodies.

Antibody Specificity↗
PubMed1979

ABH and Lewis antigens on lymphocytes: screening of pregnant women's sera with the B-cell cytotoxicity test.

Five phenotypes related to the ABH-Lewis substances were defined by the B-cell lymphocytotoxic test. These five antigens are built up in a stepwise fashion by the action of the glycosyl transferases specified by the Le, H, and the A, B genes onto the same ABO percursor molecules. The comparison of their chemical structures with the cluster analysis obtained by cytotoxicity suggests that antibodies reacting with large antigenic structures (pentasaccharides) have a more restricted specificity than antibodies reacting only with smaller antigenic determinants (trisaccharides).

ABO Blood-Group System↗
PubMed1978

Enhancement of human kidney allografts by cold B-lymphocyte cytotoxins.

The sera of 233 kidney transplant patients before transplantation were tested by cytotoxicity against a panel of B and T lymphocytes at 5 degrees C and 37 degrees C. The results divided the patients into four groups: those whose sera reacted with B lymphocytes at 5 degrees C; those reacting with B lymphocytes at 5 degrees C and 37 degrees C; those reacting with T lymphocytes at 37 degrees C; and those with no antibodies. The patients with pre-transplant antibodies reactive with B lymphocytes at 5 degrees C had a significantly higher kidney-transplant survival rate at 6 months (70%) and 1 year (65%) than patients who had no antibodies (47% and 46%, respectively). Patients with antibodies reactive at 37 degrees C had a 6-month survival-rate of 38% when reactive against B cells and 43% when reactive against T lymphocytes. The cold cytotoxins were IgM.

B-Lymphocytes↗
PubMed1977

Autoantibody against B lymphocytes.

The sera of 20 out of 99 (20%) normal males and females were shown to have antibodies that kill their own B lymphocytes. The sera were specifically cytotoxic to B lymphocytes and not T lymphocytes. Allogeneic B lymphocytes were also killed by these autocytotoxins. Maximum killing of B lymphocytes occurred when the incubation temperature in serum was 5 degrees C and complement incubation temperature was 20 degrees C. Under these cold conditions, some sera reacted up to a dilution of 1/16. These results suggest that positive B-lymphocyte crossmatches found in kidney transplantation do not detect alloantibodies. Since the B-cell autoantibodies tend to appear at the time of immunisation, their role as autoregulators of the antibody response is an intriguing possibility.

Autoantibodies↗
PubMed1977

Relation between HLA-DW and the b-lymphocyte specificities.

Homozygous DW typing cells were tested for six B-lymphocyte specificities. All four of the second locus specificities of B lymphocytes were strongly associated with the DW specificities. DW1 typing cells were B group 6, DW2 were B4, DW3 were B5, and LD107 were B3. The first B-cell locus antigens 1 and 2 tended to be uniform within the DW groups. From an analysis of the typing responses of a panel of cells to the homozygous typing cells, it has become apparent that the first B-locus specificity present on the homozygous typing cells also plays a role in determining whether a typing response is obtained or not. Thus, the DW3 typing cells were themselves B2 and B5, and cells having B2-B5 were most frequently nonreactive to DW3 in mixed lymphocyte culture. Homozygous typing cells therefore mainly detect the second B-cell locus antigens and, to a lesser degree, the first locus specificities. Stated another way, homozygous typing cells do not define a single specificity, but rather the presence of two B-lymphocyte specificities, even though their responses often reflect matching of only the second B-locus specificity.

B-Lymphocytes↗
PubMed1977

B-lymphocyte haplotypes in asthma families.

Thirty families in whom at least one member had asthma were typed for five new B-lymphocyte specificities, as well as the antigens of the A and B loci of HLA. The B-cell reactions were consistent with the concept that they were determined by genes linked to the HLA-A and HLA-B loci. Between 22 HLA-identical siblings and 16 two-haplotype different siblings, a significant difference in concordance of reactions for the B-cell groups was noted. The data obtained were most compatible with B-groups 1 and 2 being determined by one locus and B-groups 3, 4, and 5 by another locus. The superhaplotypes of HLA-A, HL-B, and B-cell loci 1 and 2 were then determined. The most striking linkages noted were for the second B-cell locus and the HLA-B locus: B-cell group 3 with HLA-B12, B-cell group 4 with HLA-B7, and B-cell group 5 with HLA-B8, B17, and Bw35.

Asthma↗