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Biomedical subjects

M S Pluzhnikov

Publications and source records attributed to M S Pluzhnikov.

At least 19 recordsLinked to original sources
PubMed2006

[Role of echography in diagnosis of diseases of cervical lymph nodes].

We studied echograms of lymph nodes and clinically similar tumors of the neck in 194 patients. A complex of echographic signs providing the best diagnostic indicators: a minimal size of the node, volume, maximal to minimal size ratio and form. Accuracy of differential diagnosis of benign and malignant lymphadenopathies was 80.4%, sensitivity -- 94.3%, specificity -- 69.4%. In duration of the disease less than 1 month use of computer processing of echograms raised diagnostic accuracy by 9.5%.

Adult↗
PubMed2003

[Laser surgery of cicatricial laryngeal stenosis].

The authors consider possibility of using surgical lasers for treatment of cicatricial laryngostenosis (CL); present classification of stenoses depending on the causes and location; emphasize advantages of high-energy laser vs conventional methods (reduced blood loss, no need in previous tracheotomy or laryngofissure, minimal reactive changes, rapid epithelization); describe the procedure of laser radiation and its variants depending on tumor location in the larynx.

Adolescent↗
PubMed2002

[Epidemiology and laser correction of chronic diseases observed in snoring and obstructive sleep apnea].

Investigations of snoring have been initiated because snoring is associated with obstructive sleep apnea syndrome (OSAS) and some chronic diseases eventuating in invalidity. Questionnaire survey provided evidence on snoring and OSAS incidence among different age groups of male and female population of St-Petersburg. Associated chronic diseases were also evaluated. Snoring and OSAS were corrected by laser uvulopalatoplasty. The correction was conducted in the contact regimen by Nd-YAG laser. As a result of the treatment, snoring and apnea in mild OSAS ceased in all the patients and decreased by at least 60% in severe OSAS. This effect was confirmed by polysomnographic findings.

Adult↗
PubMed1995

High-frequency jet ventilation in endolaryngeal surgery.

STUDY OBJECTIVE: To describe the clinical experience with high-frequency jet ventilation (HFJV) of the lungs during endolaryngeal surgery and its effect on acid-base balance and capillary PO2 (PcO2), PCO2, central hemodynamics, and tracheobronchial mucous membrane. DESIGN: Evaluation of different modalities of HFJV. SETTING: Operating rooms and otolaryngology intensive care unit in a medical institute. PATIENTS: 218 patients undergoing elective endolaryngeal surgery. INTERVENTIONS: Patients receive HFJV through catheters with an inner diameter of 1.4 to 1.8 mm. Catheters were introduced orotracheally, nasotracheally, percutaneously, or through a fenestrated tracheostomy tube. Minute volume was based on body weight times 0.2, corrected for acid-base balance. MEASUREMENTS AND MAIN RESULTS: Intraoperative cardiac output, airway pressure, changes in tracheobronchial mucosa, and acid-base balance were monitored. HFJV changed central hemodynamics slightly and preserved gas exchange: PcCO2 remained within normal limits, while PcO2 increased. Use of thin catheters enhanced largyneal exposure and surgical manipulation. Percutaneous catheterization permitted resumption of HFJV in the event of laryngeal edema and inadequate spontaneous respiration after surgery. CONCLUSION: HFJV leads to optimal conditions for endolaryngeal surgery, reverses constant outflow of the respiratory gas mixture, prevents aspiration of tissue products and blood, and removes smoke from the operative site when using laser surgery.

Acid-Base Equilibrium↗
PubMed1993

[Clinical efficacy of cefixime (results of multicenter trials)].

Multicentre trials of cefixime (Cefspan, Fujisawa Pharmaceutical Co., Ltd., Japan) were performed in 1992. The trials involved 137 children and 269 adult patients with inflammatory infections of the respiratory organs and urinary tracts and otorhinolaryngologic affections. Positive clinical and bacteriological results of the trials were stated in 76-90 per cent of the cases. The adverse reactions such as skin eruption and dyspepsia were rare and did not require the specific treatment.

Adolescent↗
PubMed1991

[Nd:YAG laser radiation alters the proteolytic resistance of the liver tissue proteins in rats].

Small tissue strips were excised from rat liver and exposed to extensive irradiation with Nd:YAG laser followed by homogenization and spectrophotometric detection of 5% TCA-soluble protein fractions (oligopeptides) in both supernatants and 5NKOH-soluble sediments of the irradiated specimens. Trypsin along, or with chemotrypsin was added to the specimens to evaluate their proteolytic resistance during and after incubation for 24 h in the proteinase(s). The results showed that Nd:YAG laser irradiation resulted in significantly more oligopeptides following either schedule of the proteolysis employed in both supernatants and sediments as compared to the unaffected proteolytically tested specimens. At the same time a proteolytically resistant 5% TCA-insoluble fraction was elicited which belonged to proteins and, judging by the parallel ultrastructural data, was located in the cellular membranes. The probable mechanisms of the observed protein modifications, along with some pertinent clinical implications of Nd:YAG laser surgery, are considered.

Animals↗
PubMed1989

[Treatment of facial granuloma with eosinophilia by using laser radiation].

Six patients suffering from Pinkus' eosinophilic granuloma of the face are described. The etiology and pathogenesis of this disease are unknown, it is resistant to whatever conservative therapy. The authors suggest an effective method of laser destruction of the foci of skin involvement, giving a good stable cosmetic result.

Adult↗
PubMed1986

[Rhinobronchial reflex in patients with bronchial asthma].

Altogether 229 patients with bronchial asthma and 57 patients with chronic bronchitis (preasthma) were examined. Diseases of the respiratory tracts, mainly of the nasal cavity and accessory nasal sinuses were found in 273 (95.45%) patients. There was correlation of the cell structure of the upper and lower respiratory tracts in patients with bronchial asthma as well as correlation in the status of the nasal and bronchial cavity mucosa. A raised rhinobronchial reflex was revealed in 33.7% of patients with bronchial asthma and a raised olfactobronchial reflex in 46.2%. Latent hyperreactivity of the bronchi was detected in 21.7% of the patients with vasomotor rhinopathy without concomitant pulmonary pathology.

Adolescent↗
PubMed1976

[Comparative kinetics of oxytetracycline and oxyglucocycline cotent in tissues of the ENT organs].

The kinetics of oxytetracycline and oxyglucocycline levels (calculated for oxytetracycline) was studied on 80 patients with chronic inflammatory diseases of the upper respiratory organs, the antibiotics being administered intramuscularly. After a single injection of oxytetrachcline hydrochloride in a dose of 1500 Units/kg body weight its levels in the blood serum and certain tissues of the ENT organs were rather low. When the dose was 3000 Units/kg the maximum antibiotic level in the blood level reached 1 Unit/ml. The drug was detected in the bacteriostatic concentrations in the blood serum and tissues within 12 hours. When the dose of oxyglucocycline was 1500 Units/kg the rate of its absorption was 4 times higher than that of oxytetracycline absorption. However, the character of its distribution in the blood and tissues of the ENT organs did not differ from distribution of oxytetracycline as dependent on the duration of the injection period. The both pharmaceutical forms had a tendency to some retention of the drugs in the tissues of the palatine tonsils. Because of better absorption and retention in the tonsils tissue oxyglucocycline may be recommended for therapy of inflammatory processes in the lymphadenoid apparatus of the pharynx.

Biopharmaceutics↗