Database management for instrument comparisons.
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Biomedical subjects
Publications and source records attributed to M S Sealfon.
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Quinidine is a commonly used drug for the treatment of cardiac arrhythmias. Avoidance of toxicity and monitoring of therapy can be readily accomplished by determining serum concentrations of quinidine by enzyme immunoassay (Emit) using a centrifugal analyzer and reducing the data with a desk-top microcomputer. For therapeutic and toxic drug ranges maximum within-run CV was under 6.0%, while between-run CV was under 10.0% in the therapeutic range and under 15.0% in the toxic range.
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Laboratory error has been estimated to occur in one to three percent of test results. Previous studies have identified common sources of laboratory-induced error. Methods of quality assurance are suggested to identify such errors and reduce the possibility of their reaching the physician. Present systems for monitoring quality assurance do not adequately detect biological and pharmacological errors.