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Biomedical subjects

M S Smout

Publications and source records attributed to M S Smout.

12 recordsLinked to original sources
PubMed1989

Extra-adrenal myelolipoma.

Extra-adrenal myelolipomas are rarely reported lesions, with only 18 cases found in the world literature. We report a series of three cases, all occurring in women in an age range of 68 to 83 years (mean, 77 years). One patient presented with a pelvic mass while the other two cases were incidental findings at autopsy. All lesions were presacral in location, encapsulated, and not attached to adjacent structures. Sizes ranged from 6 to 12 cm in greatest dimension and from 72 to 330 g. Color was a variegated yellow to red-brown. Microscopically, all were composed of mature fat and focal collections of normal hematopoietic elements. The nature of these lesions is not known but most authors favor a choristomatous origin. They must be distinguished from extramedullary hematopoietic tumors seen in patients with severe anemias, myeloproliferative disorders, and skeletal disease.

Aged↗
PubMed1986

The value of nuclear contour index in the diagnosis of mycosis fungoides. An assessment of current ultrastructural morphometric diagnostic criteria.

Skin biopsy specimens from 43 patients with established mycosis fungoides (MF) and 28 with non-MF lymphoid skin infiltrations were studied by transmission electron microscopy. The nuclear contour index (NCI) of infiltrating lymphoid cells was obtained by means of a Zeiss Videoplan computer and measuring tablet. Classification of the material into MF and non-MF groups was done according to the diagnostic criteria used by McNutt et al. (1980, 1981) and Meijer et al. (1980); this study evaluates the usefulness of these previously published criteria based on quantitative electron microscopy. Statistical analysis confirmed that the mean NCI (MNCI) of the lymphoid cells of patients with MF is significantly greater than that in patients with other lymphoid infiltrates (P less than 0.001). However, all published diagnostic criteria (McNutt et al., 1980, 1981, and Meijer et al., 1980) tested in the authors' larger patient population yielded lower sensitivity than has been reported. The diagnostic criteria based on values of MNCI, percentage of lymphoid cells with NCI greater than 7, and percentage of lymphoid cells with nuclear profile area of greater than 30 microns2 reported by McNutt et al. (1981) appear to be better than others, and provide the highest sensitivity rate, which is in the range of 44% to 47%. There were no false-positive findings. It was concluded that the use of ultrastructural morphometry according to the techniques and diagnostic criteria of McNutt et al. (1981) is useful in the diagnosis of MF.

Adolescent↗
PubMed1984

Heterotopic gastric cyst of the oral cavity.

The heterotopic gastric cyst of the oral cavity is a rare lesion. A recurrent gastric cyst in the floor of the mouth of a young female patient is presented. Current theories dealing with the histogenesis of these lesions are presented and discussed. Based on the available embryologic and clinical information, a new histogenetic concept for the development of the heterotopic gastric cyst is proposed.

Adolescent↗
PubMed1984

Canalicular adenoma: not a basal cell adenoma.

The evidence that canalicular adenomas and basal cell adenomas are separate entities is presented in this article. The clinical features were studied in a series of 13 previously unreported salivary gland tumors (5 canalicular adenomas and 8 basal cell adenomas) and 99 examples derived from the literature (68 canalicular adenomas and 31 basal cell adenomas). Representative tumors from the new cases and from 66 referred cases were studied by histologic, histochemical, and electron microscopic techniques. The two tumors differ significantly with respect to the age range of affected patients, site of predilection, and morphologic and histochemical features.

Adenoma↗
PubMed1984

Epithelial-myoepithelial carcinoma of salivary glands.

Four cases of epithelial-myoepithelial carcinoma of salivary gland origin are presented and discussed. The mean age of these four patients was 68 years, with an age range of 51 to 78 years. Three of the patients were women, and one was a man. This article emphasizes the light microscopic, histochemical, and ultrastructural features of the neoplasm. Electron microscopic examination of glutaraldehyde-fixed fresh tissue and previously formalin-fixed tissue reveals that the characteristic clear cytoplasm of abluminal cells is caused, in part, by glycogen storage granules and the paucity of organelles but largely by an artifact of fixation.

Adenocarcinoma↗
PubMed1980

Erythema nodosum migrans in a young woman.

A case of erythema nodosum migrans in a 16-year-old girl is reported. We believe this to be the youngest patient described to date. The patient responded promptly to therapy with potassium iodide. The causes, pathogenesis, and treatment of the condition are discussed.

Adolescent↗
PubMed1976

Verrucous carcinoma of the vagina.

Verrucous carcinoma of the vagina is a highly differentiated and rare variety of squamous-cell carcinoma. Two new cases are presented; a search for the literature revealed three other cases. This neoplasm is characterized by a warty verrucous pattern of growth of squamous epithelium. Histologically, this type of squamous-cell carcinoma is extremely well-differentiated, with minimal evidence of anaplasia of the cells. The neoplasm tends to grow slowly and to infiltrate, sometimes extensively, by pushing rather than by permeating the surrounding tissues. Surgical excision seems to provide the best cure at the present time as the tumor does not respond to irradiation or to podophyllin treatment. Lymph-node dissection is not usually necessary in view of the tendency of the tumor to spread locally rather than to metastasize. However, the value of resection of lymph nodes should be reassessed after enough cases have accumulated.

Carcinoma, Verrucous↗