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Biomedical subjects

M S el-Khateeb

Publications and source records attributed to M S el-Khateeb.

8 recordsLinked to original sources
PubMed1994

Prevalence of abnormal thyroid function tests in connective tissue disease.

The prevalence of thyroid function tests' abnormalities in 170 patients with various connective tissue diseases (CTD) was examined and compared to a group of 100 age- and sex-matched controls. The overall prevalence of diagnosed thyroid disease was 3.5%. Categorizing the patients into 5 "functional groups" by the concurrent thyroid function test/results showed normal thyroid function tests in 14%, isolated elevated TSH levels with normal T4 and T3 levels in 4% and findings consistent with the laboratory diagnosis of primary hypothyroidism in 3%. The "euthyroid sick syndrome" was evidenced in 54% and elevated T4 levels and/or increased or normal T3 values with normal TSH in 25%. Antimicrosomal antibodies were noted in 12 patients (7%), with the highest incidence in systemic lupus erythromatosus patients (10%). patients with mixed connective tissue disease had significantly (p < 0.0005) higher frequency of hypothyroidism, whereas patients with systemic vasculities had higher frequency of hyperthyroxinemia. In conclusion, CTD patients frequently have abnormal results of one or more of thyroid function tests. Hypothyroidism and hyperthyroidism should be considered when evaluating symptoms and signs in CTD and a significant subset of CTD patients appears to be predisposed to the development of hyperthyroidism.

Adolescent↗
PubMed1989

Comparison of antibody titres to streptococcal extracellular antigens.

Antibody titres were measured against extracellular products of group A beta haemolytic streptococci. Comparison of the titres obtained with antistreptolysin O (ASO), streptozyme, antideoxyribonuclease-B (ADN-B), antinicotinamide adenine dinucleotidase (ANAD), antihyaluronidase (ASH), and antistreptokinase (ASK), in 412 human serum specimens with different categories were tested. The results obtained were as follows: the streptozyme test was in good correlation with ASO, and can detect more specimens with elevated antibody titres than any other single test, but was not as good as the combination of any other tests like ASO and ADN-B. For determination of streptococcal infection, it is necessary to test for more than one antibody. Streptozyme test is valuable screening in combination with ASO, for those laboratories depending on ASO alone.

Antibodies, Bacterial↗
PubMed1986

HLA antigens, blood groups and immunoglobulin levels in idiopathic thrombocytopenic purpura.

Thirty-three patients with idiopathic thrombocytopenic purpura (ITP) were tested for HLA-A, B and C antigens, platelet antibodies, immunoglobulin levels and ABO blood groups. With one exception, ITP proved not to be significantly associated with the HLA antigens studied; an increased frequency of HLA-A28 was found in chronic ITP patients (50 vs. 18.7% in the control population). An increased incidence of blood group A was found in ITP patients (64 vs. 37.98% in the control population), especially in those with acute ITP (84.7%). A significant reduction of IgG levels was noted in patients with chronic ITP, while below-normal levels of IgA were found in both chronic and acute ITP patients. There was no difference in levels of IgM. Circulating platelet isoantibodies were demonstrated in 67.6% of the ITP patients. No correlation was demonstrated between the presence of platelet antibodies, immunoglobulin levels of HLA antigens.

Acute Disease↗
PubMed1986

Burkitt's lymphoma in Jordanian children: epidemiological and clinical study.

Twenty-four children with a diagnosis of Burkitt's lymphoma were seen at Jordan University Hospital during a 6 year period (1978-1983). Their median age was 4 years and the male to female ratio was 3:1. A space clustering of cases was evident. Abdominal mass was the commonest presentation being observed in 21 patients, while only two patients presented with jaw masses. Sixteen patients had advanced disease (stages C and D). Chemotherapy was the basic form of therapy given. Twelve children (50%) survived. Advanced stage and poor nutritional status at diagnosis correlated with poor outcome. Our data indicate that Burkitt's lymphoma in Jordanian children presents an intermediate type that shares some similarities with both the endemic (African) and non-endemic types.

Burkitt Lymphoma↗