The urinary xylose excretion is low in patients with untreated idiopathic steatorrhoea but subsequent improvement in excretion was noted after treatment in six out of nine patients. This did not coincide with histological improvement. With Crohn's disease low values were found when the jejunum but not the ileum was involved.

Celiac Disease↗

PubMed1961

The microvilli of the small intestinal surface epithelium in coeliac disease and in idiopathic steatorrhoea.

This paper records the electron microscopic appearances in patients with coeliac disease and idiopathic steatorrhoea, and draws attention to the changes in the microvilli.

Celiac Disease↗

PubMed1960

Coeliac disease: histopathological findings in the small intestinal mucosa studies by a peroral biopsy technique.

Villous atrophy, changes in the surface epithelium, mucosal thickening, and glandular hypertrophy were a feature of all the mucosal biopsies from the small intestine obtained from eight coeliac children. No histological differences were observed between the children previously treated with intermittent gluten-free diets and the untreated children. Serial biopsy studies were carried out on one coeliac child before and after treatment with a gluten-free diet over a period of two years. On the whole they confirmed the irreversible nature of the observed histopathological changes but minor improvements could not be excluded. Mucosal abnormalities in coeliac disease are the same as in adult idiopathic steatorrhoea, where they are observed in patients with or without a response to a gluten-free diet. It is concluded that the elimination of gluten from the diet has little if any influence on the histopathological abnormalities observed in coeliac disease.

Adult↗

PubMed1960

A report of two cases of Whipple's disease diagnosed by peroral small intestinal biopsy.

Two patients with Whipple's disease are described in whom the diagnosis was established by peroral small intestinal biopsy. Scurvy occurred in one patient.

Biopsy↗

PubMed1960