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Biomedical subjects

M Sabathie

Publications and source records attributed to M Sabathie.

16 recordsLinked to original sources
PubMed1986

[Comparative study of cefoperazone and cotrimoxazole in kidney stone surgery via percutaneous approach].

The effectiveness and drawbacks of cefoperazone and cotrimoxazole in the prevention of postoperative infections following percutaneous removal of renal stones were studied comparatively. 60 patients were divided at random into two groups. 30 subjects were given 1 g cefoperazone IV every 8 hours for 5 consecutive days starting on the day before the procedure. The 30 other patients had an infusion of 800 mg sulfamethoxazole and 160 mg trimethoprim every 12 hours on the same 5 days. Age, sex and type of surgical procedure were comparable in both groups. Results were as follows: in the cefoperazone group, one patient had intraoperative septic shock due to a stone infected by a resistant Pseudomonas aeruginosa; in the cotrimoxazole group, 2 patients had postoperative fever due to stones infected by resistant Gram negative rods (Pseudomonas aeruginosa) and three patients had a urinary tract infection (Candida albicans in 1 case, Escherichia coli in 1 and Pseudomonas aeruginosa in 1). Tolerance was satisfactory for both regimens. The authors conclude that intravenous cefoperazone in the more effective drug and should be continued throughout the first three postoperative days.

Adolescent↗
PubMed1983

[Treatment of ventriculitis caused by Staphylococcus epidermidis on equipment with the combination of fosfomycin and an aminoglycoside. Course of ventricular levels of fosfomycin].

Five patients (4 adults and 1 child) with cerebrospinal fluid shunt infections caused by Staphylococcus epidermidis were successfully treated by fosfomycin combined with an aminoglycoside. Fosfomycin was given intravenously over 4 hours 3 times a day. The antibiotic dose was 12 g/day for adults and 200 mg/kg/day for the child. In 3 patients with an external CSF drainage system, serum and ventricular fluid samples were obtained before and after one infusion during 10 days. The serum concentrations varied greatly (48,12 +/- 31,47 and 115,07 +/- 46,5 micrograms/ml. However the drug levels in ventricular fluid were constant and similar for the 3 patients (24,48 +/- 10,28 à 27,87 +/- 8,58 micrograms/ml), well above the MICS (1 and 2 micrograms/ml).

Adolescent↗
PubMed1981

[Comparative study of 3 synthetic amino acid solutions: Azonutril 25, Totamine Concentré Glucidic and Vamine in digestive postoperative intensive care. Apropos of 120 patients].

In order to compare the assimilation of the three most widely used amino acid solutions: Azonutril 25 (R), Totamine concentré glucidique (Carbohydrate concentrated Totamine) and Vamine (R), a study was undertaken of daily and cumulative nitrogen balances during the first five postoperative days in 120 patients after digestive surgery, divided into three groups and receiving parenteral alimentation only. The three groups were identical in terms of age, weight and sex, as well as the type of surgery performed. Daily calorie and nitrogen intake was identical in the three series. Daily nitrogen balance was calculated using the approximation method described by Apfelbaum based upon urinary urea excretion and by estimation of digestive nitrogen losses. Daily nitrogen balance showed a significant difference on D4 between the Azonutril (R) series (+ 1.8 g +/- 2.9) and the Totamine (R) (+ 3.3 g +/- 2.2) and Vamine (+ 3.1 g +/- 3.3 g) groups, On D5, the difference was statistically very significant between the Azonutril (R) group (+ 1.1 g +/- 3.3) and the Totamine (R) (+ 2.9 g +/- 2.7) and Vamine (R) (+ 3 g +/- 2.6) groups. Study of cumulative balances for four then five days confirmed statistically the better assimilation of Totamine (R) and of Vamine (R) which in the opinion of the authors are better balanced from a quantitative standpoint.

Adult↗
PubMed1980

[Accidental overdose of alfatesine in a child with multiple malformations].

An overdosage of alfathesin was accidentally administered to a 4 kg infant with multiple congenital anomalies during an operation for craniosynostosis. The overdose was a consequence of a mistake in adjusting the rate of administration of a constant flow infusion pump. The total dosage corresponded to eight times the necessary dose administered over a period of 30 minutes. The only notable effect was a delayed awakening, which necessitated assisted ventilation. The high therapeutic index of alfathesin is responsible for the absence of serious consequences.

Alfaxalone Alfadolone Mixture↗
PubMed1977

[Study of a new anesthetic agent: etomidate (R 26490). Electroencephalographic aspects].

Etomidate or R 26490 is a new hypnotic agent produced by JANSSEN and al. in 1971. The first human experimentation was performed in 1972. The authors used Etomidate for 300 anaesthetics given for neuroradiological investigations. Two protocols were used for study: 25 anaesthetics were given with Etomidate as sole anaesthetic to outline its specific properties; 275 angiographies were performed with a combination of Etomidate and fentanyl. In protocol no. 1, the mean consumption was for 1,85 mg/kg/h, in protocol no. 2, the mean consumption was of 0,9 mg/kg/h. Pharmacological study of this drug defines it as a short acting hypnotic agent of low toxicity. Clinical observation shows cardiovascular and respiratory stability. However, frequent myoclonias were noted, when Etomidate was given as a sole anaesthetic. EEG recording and evoked response encephalography helped to outline some effects of Etomidate on central nervous system.

Adolescent↗