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M Sabriá Leal

Publications and source records attributed to M Sabriá Leal.

13 recordsLinked to original sources

[Reduction of hematogenous infection in HIV positive patients following highly active antiretroviral therapy].

BACKGROUND: Bloodstream infections have probably decreased in HIV patients since highly active antiretroviral therapy (HAART) usage. PATIENTS AND METHOD: Hematogenous infections, including mycobacteria and fungi in HIV patients, stratified into two periods (I: 1995-1996 and II: 1997-1998) were included to evaluate changes attributable to HAART. RESULTS: 226 episodes were attended (incidence: 38.8 in period I and 15.3 in period II; p < 0.01). A significant decrease was observed in immunosuppression related microorganisms. HAART usage increased from 6.4% in period I to 31.2% in period II. Immunological parameters of HIV patients significantly improved in period II. CONCLUSIONS: Hematogenous infections have significantly decreased in HIV patients since the use of HAART.

AIDS-Related Opportunistic Infections↗

[Myoglobin].

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Humans↗

[Pseudomononucleosis induced by diphenylhydantoin (author's transl)].

The authors report a patient who developed a mononucleotic syndrome after 2 months treatment with diphenylhydantoin. The clinical and biological criteria needed to establish the diagnosis of pseudomononucleosis are listed, while other possible causes described in the literature have been excluded. Complications which may occur during anti-convulsant therapy with diphenylhydantoin are reviewed and the few cases of pseudomononucleosis in the literature noted. Diagnosis was established through eliminating other possible causes, as the only definite test-drug induced reaction-is hazardous to the patient.

Child↗

[Hepatic adenomas and oral contraceptives. Report of two cases and review of the literature (author's transl)].

The authors report two cases of benign liver tumors which were histopathologically diagnosed as liver adenomas. Both patients had a former history of taking oral contraceptives. The authors carry out a critical review of the literature up until the present day and evaluate the data which exist for and against the relationship between oral contraceptives and hepatic tumors. These are based mainly on suggestive clinical observations and on experimental studies with animals, and also on the structural affinity of oral contraceptives with androgen compounds. The latter are drugs that are very much implicated in the genesis of hepatic tumors. A criticism is made on the terminology used, from a histological point of view, to describe the tumor lesions that are related to oral contraceptives; the presence of dilated vessels with find walls and the existence of hepatic peliosis inside of such tumors are emphasized. The clinical presentation of these tumors is reviewed very briefly and the authors conclude that oral contraceptives have a close relationship with the appearance of liver tumors, either inducing them directly, or at least, helping them to grow.

Adenoma↗