Biomedical subjects
Publications and source records attributed to M Sachsenmaier.
Erythropoietin levels have been determined in 24 patients with different gynecologic malignancies, who were treated with cisplatinum and endoxan. A statistically highly significant decrease was demonstrated 2 h after starting treatment with a further significant decrease at 6 h. After 12 h the erythropoietin concentrations returned to values similar to those before treatment started.
The combination of intracavitary and external-beam radiation is the treatment of choice in advanced cervical cancer. Low-dose regimens using radium were widely abandoned in favour of high-dose-rate afterloading systems. We compared in this retrospective analysis of 550 patients the 2 different treatment modalities. We could observe neither in overall survival, nor in the incidence of side effects, any significant difference. Although the change from low- to high-dose-rate radiation therapy was not accompanied by a benefit in survival, the latter modality displayed several advantages e.g. a reduced exposure of personnel to radiation and shorter duration of confinement to bed. Patient survival rate was dependent mainly on parameters of tumour burden (FIGO stage), i.v. pyelogram or CT scan of paraaortic lymph nodes. On the other hand, neither the histological classification as epidermoid or adenocarcinoma nor the WHO grading, were useful predictors of patient outcome.
At the Gynaecological Department of the University of Innsbruck, 207 nipple stimulation for the induction of uterine contractions were performed, using the necessary precautions, in 186 pregnant women at term. The continuous or intermittent manual stimulation by the patient was mainly used for contraction stress testing. An adequate uterine response (at least 3 contractions per 10 minutes) was achieved in 57%. Reversible signs of hyperstimulation, such as prolonged uterine contractions and tachysystoles, were observed in 10%, causing reversible pathologic fetal heart rate patterns in 1%. The classical intravenous oxytocin challenge test produced a higher uterine response rate as compared at the same time to breast stimulation. Provided, that an adequate response was achieved, normal and pathological fetal reaction patterns were identical in both tests. In 20 patients we used nipple electrostimulation. Results were similar to those achieved by manual stimulation. Due to the conflicting reports in the literature and because of the potential hazards involved, the use of nipple stimulation for the induction of uterine contractions can be advocated only in a controlled clinical setting. Its application without medical supervision, as propagated in the lay press, is definitely contraindicated.
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In 19 patients receiving a cytostatic therapy with epirubicine and cisplatinum, 31 times in total the renal loss of magnesium was determined using the colorimetric xylidile-blue-method. 16 patients, whose magnesium input postoperatively was equally well known, served as a control. In all these patients a negative magnesium balance could be demonstrated being significantly higher (p less than 0.01) in those receiving cytostatic therapy.
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