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Biomedical subjects

M Saigusa

Publications and source records attributed to M Saigusa.

At least 19 recordsLinked to original sources
PubMed1988

[Synergistic activity of isepamicin and beta-lactam antibiotics against Pseudomonas aeruginosa in vitro and in vivo].

Synergistic activities of isepamicin (ISP) and a beta-lactam antibiotic such as piperacillin (PIPC) or cefotaxime (CTX) against Pseudomonas aeruginosa were demonstrated in vitro and in vivo. In vitro synergistic activity was observed when ISP was used together PIPC or CTX. The synergy observed in vitro was reproduced in vivo against experimental mouse infections, and a ISP-PIPC or a ISP-CTX combination showed significantly greater protective effects than individual antibiotics by themselves.

Animals↗
PubMed1979

Relationship between renin activity and aldosterone release in the patients with low cardiac output syndrome after open cardiac surgery.

Plasma renin activity and aldosterone concentration were measured by radioimmunoassay technique in seven patients with low cardiac output syndrome after open cardiac surgery. Plasma renin activity and aldosterone concentration markedly increased, and plasma renin activity was well correlated with plasma aldosterone concentration. Plasma renin activity and aldosterone concentration, however, had no direct correlation with plasma sodium and potassium concentration or administered doses of inotropic agent, potassium and diuretic. Sodium and potassium balance was closely correlated with plasma aldosterone concentration. In the present study, it was suggested that the secondary hyperaldosteronism following low cardiac output syndrome after open cardiac surgery was mainly induced by the increased release of renin and that it influenced on the balance of sodium and potassium metabolism under such disturbed circulatory circumstances.

Adolescent↗
PubMed1979

Apparent suppression of ventricular parasystole by cardiac pacing.

Complete disappearance of ventricular parasystolic beats by cardiac pacing with the rates of near multiples of the parasystolic rate was observed in 2 patients with ventricular parasystole. This finding represents a clinical counterpart of recently demonstrated experimental and mathematical models of electrotonic modulation of the parasystolic discharge.

Adolescent↗
PubMed1977

Pulmonary regurgitation following total correction of tetralogy of Fallot.

A method is described for quantifying pulmonary regurgitation. This method is based on a comparison of the right and left ventricular stroke volumes which are determined from biplane angiocardiograms. These techniques were applied to study 18 postoperative patients with tetralogy of Fallot. In patients with an outflow patch, regurgitant fraction was well correlated with regurgitant area. The RVEDV/LVEDV ratio was also correlated well with regurgitant fraction. Although majority of patients maintained normal RV ejection fraction, there were small number of patients with large regurgitant fraction and decreased RV ejection fraction.

Adolescent↗
PubMed1977

Optimal size of outflow patch in total correction of tetralogy of Fallot.

Hemodynamic and angiocardiographic studies were performed in postoperative patients with tetralogy of Fallot. Pressure gradient between the right ventricle and pulmonary artery was correlated with the narrowest area in the pulmonary arterial pathway. Regurgitant fraction was also correlated with regurgitant area which was determined by preoperative area of the pulmonic annulus and width of the outflow patch. Follow-up study of postoperative patients with tetralogy indicated that those with pressure gradient less than 20 mmHg and regurgitant fraction less than 15% could be considered ideally corrected. A table was constructed for determining the most appropriate width of the outflow patch for the ideal correction.

Humans↗
PubMed1976

Echocardiography and angiocardiography for detection of left atrial thrombosis.

Diagnostic capabilities for detection of the left atrial clot in patients with mitral stenosis were compared between echocardiography and angiocardiography. Large clots in the left atrial body were correctly diagnosed either by echocardiography or by angiocardiography. Clots in the left atrial appendage were not disclosed by echocardiography. Left atrial visualization with pulmonary arteriography offers only possible diagnosis of the clot in the appendage. Definite diagnosis of the clot in this location requires transseptal left atriography.

Angiocardiography↗
PubMed1976

Effects of allopurinol on tissue oxygen tension of the ischemic myocardium.

The effects of allopurinol on the myocardial oxygen metabolism were studied in dogs with acute coronary artery occlusion. Upon occlusion of the contributory branch of the coronary artery, myocardial pO2, as measured with an improved polarographic technique, decreased to various lower values depending on the site of the electrode inserted. In the slightly ischemic myocardium, where myocardial pO2 decreased less than 50% of the control by the coronary occlusion, administration of allopurinol brought about a further diminution in myocardial pO2. In the severly ischemic myocardium, where myocardial pO2 decreased more than 50% of the control upon the coronary occlusion, no significant change was observed following allopurinol infusion. Theoretical beneficial effects of allopurinol on the ischemic myocardium by preserving functional purine bases might be offset by the aggravation of the negative oxygen balance in the ischemic but still viable myocardium following administration of allopurinol.

Allopurinol↗