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Biomedical subjects

M Saiki

Publications and source records attributed to M Saiki.

At least 55 records · Page 3Linked to original sources
PubMed1996

Squamous cell carcinoma arising in a verrucous epidermal nevus.

A 74-year-old Japanese male patient with squamous cell carcinoma arising in an epidermal nevus is described. The patient had widespread warty lesions involving large parts of the body since infancy. Recently, a nodular lesion appeared on the middle part of his back and increased in size. Histologically, the nodule was diagnosed as squamous cell carcinoma and the warty lesion showed the features of epidermal nevus. The nodular lesion was totally excised and the skin defect was covered with split-thickness skin grafting. To the best of our knowledge, this is the 16th patient with malignant change of a verrucous epidermal nevus.

Aged↗
PubMed1995

Intraorbital malignant lymphoma presenting with tumor stain on angiography--case report.

A 58-year-old male presented with a 1 month history of left retro-orbital pain and diplopia. Computed tomography demonstrated an isodense intraorbital tumor with slight homogeneous enhancement. Magnetic resonance imaging showed the tumor was isointensity on T1-weighted imaging, slightly high intensity on T2-weighted imaging, and slightly enhanced by gadolinium-diethylenetriaminepenta-acetic acid. Left external carotid angiography showed a tumor stain fed from the branches of the left internal maxillary artery. The tumor was partially removed. The histological diagnosis was malignant lymphoma. Tumor staining is rare in intraorbital malignant lymphoma and is not adequate for differential diagnosis of intraorbital tumors, so biopsy is essential.

Carotid Artery, External↗
PubMed1995

[Studies concerning the pathogenesis of trigeminal neuralgia caused by cerebellopontine angle tumors].

It has been well recognized that neurovascular compression can elicit trigeminal neuralgia (TN) and microvascular decompression surgery has become popular as a radical treatment of this clinical symptom. Cerebellopontine (C-P) angle tumors, however, as well known, can also cause TN. Four hundred fifty six patients with TN underwent posterior fossa exploration between 1984 and 1992 in our clinic, and among them, 45 (9.9%) patients harbored C-P angle tumors which were causative of TN. They included 22 epidermoids, 18 meningiomas and 5 neurinomas. The patient population consisted of 35 women and 10 men, ranging in age from 28 to 73 years, with a mean age of 51.7 years. The mean age of the patients of TN with tumors is considerably lower than that of neurovascular compression patients (61.0 years), particularly in cases of neurinomas (44.4 years) and epidermoids (48.0 years) (p < 0.01). Such difference in ages at the onset of symptom may be explained by the fact that the tumor growth in the C-P angle develops earlier than changes of the vasculature of the vertebrobasilar artery system by aging. Anatomical relationships between the 5th cranial nerve and offending arteries or tumors verified at surgery are as follows; Type A: The nerve is totally encased by the tumor. Type B: The axis of the nerve is distorted by the tumor. Type C: The nerve is shifted by the tumor and is compressed by the artery contralaterally. Type D: The nerve is compressed by the artery which was displaced by the tumor.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1995

[Treatment of intractable postherpetic neuralgia and blepharospasm: intraneural injection of adriamycin].

Adriamycin, an anthracycline antineoplastic agent, can swiftly be transported to the sensory or somatic motor neurons by way of axoplasmic transport when injected into the subepineurium of the trigeminal nerve or sciatic nerve in experimental animals, and is consequently able to induce degeneration of the neurons without any systemic side effects. Intraneural injection of this agent was carried out for the treatment of a total of 22 patients presenting with intractable neural dysfunction (12 with neuralgia, including 7 with post-herpetic neuralgia and 10 with facial dystonia). The nerve which innervated the affected site was exposed under local anesthesia and approximately 10-60 microliters of 1-20% adriamycin was injected into the subepineurium. Results of the treatment after average follow-up periods of 21.5 months were as follows: Out of 12 patients with neuralgia, good results were obtained in 2 cases (16.7%), fair results in 6 cases (50.0%) (overall effective rate 67.7%). There were no changes in symptoms in 4 cases (33.3%). Out of 10 patients with facial dystonia, good results were obtained in 2 cases (20.0%), fair in 2 cases (20.0%) (overall effective rate 40.0%), and no changes in symptoms in 6 cases (60.0%). No major complications were encountered during these procedures and, once symptoms had disappeared after the treatment, no recurrence of symptoms was experienced. This method clearly differs from other various kinds of simple peripheral neurotomy, since transection of the peripheral nerve does not cause any, destructive changes in the sensory ganglion or motor nucleus and, hence, symptoms may recur.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1995

Trigeminal neuralgia: association with tentorial meningioma and persistent primitive trigeminal artery.

A rare case of trigeminal neuralgia caused by tentorial meningioma associated with a persistent primitive trigeminal artery (PTA) is reported. This case involved a 59-year-old female patient with a more than 6 month history of left trigeminal neuralgia. A left cerebello-pontine angle (CP angle) meningioma was found associated with a right PTA connecting the proximal portion of the cavernous internal carotid artery with the basilar artery, supplying the bilateral superior cerebellar arteries. The tumor was totally removed via the suboccipital approach, which relieved the pain completely. Since the combination of a CP angle meningioma and a PTA is quite rare in patients with trigeminal neuralgia, we have presented this case here.

Basilar Artery↗
PubMed1994

Determination of trace elements in human lung samples.

Lung samples from smokers, nonsmokers, and one stillborn were analyzed by an instrumental neutron activation analysis (INAA) method. Pulmonary tissue and hilum lymph node samples were obtained separately from autopsies, and then submitted to cryogenic homogenization, lyophilization, and sterilization. Short and long irradiations were performed in an IEA-R1 nuclear reactor, and gamma-ray activities were measured using a Ge(Li) or hyperpure Ge detector. Precision of results was evaluated by analyzing one lung tissue in replicates and their accuracy by analyzing reference materials. Comparisons were carried out between results obtained in pulmonary tissues and lymph nodes, as well as those obtained in samples from different groups of individuals.

Adult↗
PubMed1994

Neutron activation analysis of biological samples at the radiochemistry division of IPEN-CNEN/SP.

Neutron activation analysis is a very useful method for determination of a great number of elements in biological samples. At the Radiochemistry Division of the IPEN-CNEN/SP, this method is being extensively applied to study several materials, such as extracts from medicinal plants, human hair, snake venoms, human lungs, food-stuffs, and corn samples. Both instrumental neutron activation analysis (INAA) and radiochemical neutron activation analysis (RNAA) are used to analyze real samples, as well as biological standard reference materials to evaluate the accuracy and precision of the results.

Brazil↗
PubMed1994

Comparative study of methods for determining lanthanide elements in biological materials by using NAA, HPLC postcolumn reaction, and ICP-MS.

Mice were injected intravenously with one of the following elements: Y, La, Ce, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, or Yb, at a dose of 25 mg/kg body wt. After 20 h, the various organs were taken out, and the element concentrations were determined by NAA, HPLC postcolumn reaction, or ICP-MS. The results by these three methods were within the acceptable range. About 85% of the amount administered of each element was found in liver, lung, and spleen.

Animals↗
PubMed1994

Unusual presentation of brain metastasis from hepatocellular carcinoma--two case reports.

Two unusual cases of brain metastasis from hepatocellular carcinoma (HCC) are described. A 15-year-old boy presented with intracerebral hemorrhage from brain metastasis from HCC, and died of rebleeding 1 month after surgery. Cerebral metastatic HCC in a child is quite rare, and has not previously been reported. A 65-year-old male with a 2-year history of treatment for HCC presented with a brain metastasis from HCC without intracerebral hematoma manifesting as gradual onset of headache. Brain metastases from HCC presenting without intracerebral hemorrhage are rare.

Adolescent↗
PubMed1994

[Diploic epidermoid on the petrous bone: a case report].

An unusual case of a congenital petrous bone epidermoid which resulted in a sudden deafness is reported. The patient was a 25-year-old man who suddenly developed a right deafness and tinnitus. Neurological examination on admission revealed slight hearing disturbance in the high sound area. Plain craniogram showed a destructive bone lesion in the middle portion of the petrous bone on the right side. Bone-window CT scan disclosed a bony destructive mass in the petrous bone, and enlargement of the internal auditory canal. The mass lesion was almost isodense on plain CT scan and was not enhanced by contrast media. T1 weighted imaging of MRI demonstrated an isointense mass in the petrous bone, and T2 weighted imaging demonstrated hyperintensity. Gd-DTPA MRI revealed no enhancement. Angiogram did not reveal abnormal findings. Right lateral suboccipital craniectomy was performed to remove the posterior wall of the internal auditory canal. The tumor existed extradurally originating from the dipole of petrous bone. The tumor appeared pearly and fragile. The pathological examination of the specimen was diagnosed as epidermoid. The postoperative course was uneventful except for right hearing loss on the 4th postoperative day. Epidermoid arising in the middle portion of the petrous bone is quite rare, so this case was hereby reported with some references.

Adult↗
PubMed1993

[A case of macrocystic cervical neurinoma diagnosed by MRI with Gd-DTPA].

The authors report a rare case of a large cystic cervical neurinoma. A 45-year-old female was admitted to our clinic because of motor weakness of the right upper extremity, numbness of the right fingers and right posterior cervical pain. Metrizamide CT myelography demonstrated the outline of a low density mass. MRI showed a mass revealing low signal intensity on T1-weighted image, high signal intensity on T2-weighted image and marginal enhancement on contrast image with Gd-DTPA. The mass which was diagnosed as cystic tumor, was located in the intradural extramedullary space between C4 to C5 segments. After C4 through C5 laminectomy, the tumor was found to originate from the C5 anterior motor root. The tumor consisted mostly of a cystic part with a very thin solid compartment beneath the capsule. Postoperative course of the patient was uneventful. Although spinal neurinoma is one of the most common spinal tumors, an almost completely degenerated large cystic spinal neurinoma is extremely rare. MRI with Gd-DTPA was useful for the diagnosis of the cystic neurinoma by clearly enhancing the margin of the tumor.

Cysts↗
PubMed1988

Cell kinetics studies of human brain tumors by in vitro labeling using anti-BUdR monoclonal antibody.

Since the development of a specific monoclonal antibody against the thymidine analogue bromodeoxyuridine (BUdR), many investigators have used intravenous infusion of BUdR to estimate the proliferative potential of human brain tumors. However, side effects such as the induction of cell mutation, latent virus promotion, or inhibition of cytodifferentiation cannot be ignored, and thus many workers hesitate to use it in patients, especially those with hepatic disease or of reproductive age. Furthermore, if BUdR remains in the deoxyribonucleic acid of tumor cells after injection, analysis of the effect of chemical and radiation therapy may not be evaluated correctly. In this report, in vitro BUdR labeling with an anti-BUdR antibody is compared with the in vivo methods described by previous authors. This method appears to be useful for determining the S-phase fraction of human brain tumor. It was more rapid, and was simple, safe, and reproducible as compared to the intravenous infusion method.

Antibodies, Monoclonal↗