Biomedical subjects
Publications and source records attributed to M Saini.
A 57 year old male had recurrent arthritis and uveitis for 34 years, spinal symptoms for 10 years, and malabsorption for four months leading to the diagnosis of ankylosing spondylitis and Whipple's disease. HLA-B27 was positive. Out of the four cases of Whipple's and ankylosing spondylitis in the literature, only one had been tested for HLA-B27 and was found to be negative.
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Explore the source record for details and available documents.
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This study was undertaken to assess the effect of propane-1,2-diol(PD) ingestion on carbohydrate metabolism in female rat erythrocytes. For this purpose, two different groups of adult albino female rats were treated orally with PD at two different dose levels of 73 and 294 mg 100 g-1 body wt. The blood samples drawn from the retro-orbital sinus prior to the treatment served as the controls, whereas the treated samples were collected at peak periods (1/2 and 2 h) 2 and 7 days after the treatment. A single dose of PD was found to elevate levels of blood glucose, lactate, pyruvate and the lactate/pyruvate ratio at the peak periods (P < 0.001) and after 2 days (P < 0.001) in both the groups. A significant (P < 0.05) increase in the contents of erythrocyte 2,3-diphosphoglycerate (2,3-DPG) was observed only at the peak periods. All these parameters returned to their base level after 7 days of treatment. The activities of hexokinase (HK), 2,3-diphosphoglycerate phosphatase (2,3-DPG Pase), lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G-6-PD), 6-phosphogluconate dehydrogenase (6-PGD) and aldehyde reductase II (AR II) declined markedly, whereas those of pyruvate kinase (PK) and aldose reductase increased as a result of PD ingestion. The changes in the activities of 2,3-DPG Pase and LDH were persistent up to 8 days post-treatment. The [14C]glucose flux through glycolysis and the hexose monophosphate shunt pathway in erythrocytes was found to be lowered (P < 0.001) in response to PD treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
The present study determined the proportion of energy consumption used to lift the center of mass vertically during walking. By assuming that the vertical oscillations of the trunk were identical to those of the center of mass, the complexity of studying the human gait was simplified. The work performed on the center of mass, defined as lift work, was calculated using the subject's mass and the vertical displacement of the trunk. Compensating for the fact that human muscles are approximately 25% efficient in performing external work, the mechanical work was compared with the total energy expenditure, determined using an expired air analysis. At 1.34 and 1.79 m/s, 53.2 +/- 9.3% and 62.8 +/- 8.6%, respectively, of the total energy can be explained by lift work. At 0.45 and 0.90 m/s, the proportions are considerably less, 21.6 +/- 6.6% and 37.6 +/- 8.2%, respectively. These findings provide a rationale for why the metabolic energy cost per unit distance is greater at slower speeds than comfortable or fast speeds of walking. The total energy consumption can be accounted for by changes in the potential and kinetic energies and internal muscular work, defined as the less readily observable work probably needed for balance. The present study demonstrated that the metabolic energy cost of changing the potential energy of the center of mass during walking is significantly less relative to the total energy consumption at slower speeds than at higher speeds. Because kinetic energy is proportional to the square of the velocity, the metabolic energy cost of changing this energy is relatively small at slower speeds. Internal muscular work must therefore play a large role in total energy consumption at slow speeds of walking.