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Biomedical subjects

M Salm

Publications and source records attributed to M Salm.

7 recordsLinked to original sources
PubMed1989

Vasoactive pharmacologic responses of human skin xenografts in ciclosporin-treated rats.

Human skin xenografts in ciclosporin-treated rats have been reported to preserve many of the characteristics of normal human skin. This model was used to study the cutaneous responses of human skin xenografts and host rat skin to intradermal injections of vasoactive agents. The xenograft responses to corticosteroids (blanching), nicotinic acid (erythema), histamine HCl (urticaria), and privine (blanching) all paralleled those of the host rat skin. However, when quantitatively compared to the responses reported for human skin in vivo, the xenografts were less sensitive to these compounds. The large variability seen in the xenograft responses may be due to variable graft revascularization and to structural irregularities in the dermis from the recent grafting procedure. It is concluded that the lower sensitivity and variable responsiveness of the xenografts limit the potential usefulness of this pharmacologic model for evaluating vasoactive agents.

Animals↗
PubMed1984

Localized cicatricial pemphigoid (Brunsting-Perry). A transplantation experiment.

Normal skin was transplanted into a cicatricial plaque in a patient affected with localized, benign pemphigoid of the Brunsting-Perry type. Eight weeks later, the transplanted tissue was removed and found to have IgG at the basement membrane zone on immunofluorescence microscopy. Subepidermal bullae developed at the graft-donor site. Local factors and trauma may be important in the pathogenesis of this variant of cicatricial pemphigoid.

Administration, Oral↗
PubMed1983

Juvenile pemphigus.

Seven cases of juvenile pemphigus vulgaris and one case of juvenile pemphigus foliaceus are presented. A detailed review of the literature is also presented. The majority of patients with juvenile pemphigus develop pemphigus vulgaris. The patients present with a wide clinical spectrum. The oral cavity is frequently involved. The mean duration is 4 years. Clinical follow-up is similar to the adult variety. Several patients warrant high doses of systemic corticosteroids and develop serious side effects, most notably growth retardation and opportunistic infections. Short-term judicious use of immunosuppressive agents is advocated. Dapsone is a helpful adjuvant to therapy. It is proposed that relevant immunofluorescent studies be done very early. Early diagnosis and therapy are associated with a better prognosis.

Adolescent↗