Biomedical subjects

M Sam Eljamel

Publications and source records attributed to M Sam Eljamel.

4 recordsLinked to original sources

PubMed2006

A simple stereotactic method for frameless deep brain stimulation.

BACKGROUND: Deep brain stimulation (DBS) is widely used to treat advanced Parkinson's disease, other movement and psychiatric disorders. DBS implantation requires application of a stereotactic frame throughout a lengthy procedure, making it uncomfortable and tiring. We designed a stereotactic cube to stage the operation, perform frameless microelectrode recording (MER) and fix the DBS. METHODS: The 15-mm cube is implanted in a burr hole using bone cement. It contains 5 parallel trajectories (central + 4 around). It is aligned by stereotactic frame so that central trajectory reaches the target. Frameless MER is performed by attaching a micro-driver to the cube using 2-5 cannulae (4 cm). The DBS is fixed to the cube by a mini-plate and 1 screw. Ninety-six cubes were compared with 43 Bennet spheres (BS). RESULTS: No cube moved compared to 2 (5%) BS (p < 0.05). The final trajectory was central in 64.4% of cubes compared to 47.5% of BS, and the final target was >2 mm out in no cubes compared to 12.5% of BS (p < 0.01). Infection and haemorrhage were observed in 2.5% and 3.3% of cubes, respectively, while 5% of BS developed infection, 5% haemorrhage and 7.5% skin erosion. CONCLUSIONS: This method is simple and effective in staging DBS procedures, performing frameless MER and DBS implantation, fixation and revision.

Adult↗

PubMed2003

From letterbox to keyhole approach for resecting intracranial lesions.

BACKGROUND: Computer-assisted neurosurgery systems (CANS) have the ability to translate preoperative image data sets directly to the operating field and were thought to be very useful in neurosurgery. However, key questions regarding their use remain only partially addressed. METHODS: To answer the doubts of the skeptics, we set up a registry of all CANS and any non-CANS procedures in our institution. The results of 354 procedures are presented in this paper. RESULTS: CANS was used in 254 procedures, with a mean accuracy of 1.9 mm and a failure rate of 2.8%. Over time, the accuracy improved to 1.6 mm and failures were abolished. The CANS was most useful in anterior skull approaches and took less time in the operating room, and the patients were discharged earlier than those who underwent non-CANS procedures. CONCLUSION: We feel that the introduction of CANS has changed our practice for the better, with significant benefits to patients, surgeons and the hospital at large, and we recommend its usage as a standard of care.

Humans↗

PubMed2003

Spinal cord stimulation for the treatment of refractory unilateral limb pain syndromes.

BACKGROUND: Spinal cord stimulation (SCS) is an established therapy for chronic pain. Its success depends on vigorous patient selection and good follow-up. METHODS: We reviewed 75 patients who had undergone SCS to establish their outcome. 67 of these patients had refractory unilateral limb pain syndrome (RULPS). Their case notes and operative log books were critically reviewed, and when appropriate, telephone interviews were performed (58 patients). RESULTS: 87% of patients responded initially to SCS; at 6 months, the effect waned to 79%, and by 2 years, it improved to 84%. One third of the patients had no revisions, 40% had IPG replacements and the rest had revisions because of lead-related complications (5.3%), epidural complications (mainly fibrosis; 19%) or infections (2.7%). 56% of patients reduced their analgesia, 1.5% stopped taking any painkillers and 46.8% of those who were employed returned to work. CONCLUSION: We feel that SCS is an effective treatment in RULPS and its results depend upon vigorous patient selection and an adequate follow-up and maintenance program.

Electric Stimulation Therapy↗

PubMed2003

New light on the brain: The role of photosensitizing agents and laser light in the management of invasive intracranial tumors.

Invasive intracranial tumors, particularly malignant gliomas, are very difficult to eradicate surgically and carry a dismal prognosis. The vast majority relapse locally indicating that their cure is dependent on radical and complete local excision. However, their ability to invade and hide among normal brain tissue, our inability to visualize and detect them, the low tolerance of brain tissue to ionizing radiation and the presence of the blood brain barrier are the main causes of our failure to eradicate them. Photodynamic detection with 100% specificity and more than 80% sensitivity offers an excellent chance of visualizing camouflaged tumor nests. Also, photodynamic therapy offers a very good chance of targeted destruction of the remaining tumor cells safely following surgical excision and may double the survival of patients harboring these awful tumors. More work needs to be done to refine this promising technology to exploit it to its full potential.

Aminolevulinic Acid↗