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Biomedical subjects

M Santarelli

Publications and source records attributed to M Santarelli.

9 recordsLinked to original sources
PubMed1991

Bihemispheric organization of amygdalo-cortical projections in the rat.

Two fluorescent dyes were injected symmetrically into the prefrontal cortices of the left and right hemisphere. A consistent number of amygdaloid neurons was labeled from the injection in the contralateral cortex. Each nucleus of the basolateral amygdaloid complex showed a specific pattern of contralaterality. The highest degree of bihemisphericity was observed in the ventral basolateral nucleus. A significant number of neurons connected with the cortex of both hemispheres by means of axon collaterals was observed in the anterior basolateral nucleus. These anatomical findings indicate that the basolateral amygdaloid complex could act as subcortical link for interhemispheric communication.

Amidines↗
PubMed1991

[Neoplasms of the base of the tongue. Evaluation with magnetic resonance].

The authors investigated MR capabilities in evaluating the neoplasms of the base of tongue. Thirty patients were examined. The images were obtained--at INI, Grottaferrata, Rome--using a 1.5 T superconductive Gyroscan unit by Philips. On T2-weighted images, the neoplasms were always hyperintense; in 10 patients edema could be distinguished from neoplasm. On T1-weighted scans the tumor exhibited the same signal intensity as the tongue muscle in 4 patients, while in the extant 26 cases it was hypointense. This pattern proved to be aspecific and could not be correlated with a specific histology. In 3 clinically symptomatic patients, MR imaging diagnosed the invasion of the internal pterigoid muscle. MR capabilities in identifying swollen lymph nodes was also evaluated on the basis of the signal intensities of the latter, as well as on their size. The authors' conclusion is that MR imaging is to be considered the method of choice in the staging of tumors at the base of tongue thanks to its high contrast resolution and multiplanar capabilities.

Aged↗
PubMed1990

[Radiotherapy in the treatment of tumors of the nasopharynx in advanced stage].

This series consists of 25 patients affected with nasopharyngeal carcinoma in an advanced stage (T3-T4) treated at the Radiation Oncology department of the Institute of Radiology, University "La Sapienza", Rome, from 1978 through 1988. The patients were irradiated with X-rays produced by a LinAc with 4 MeV energy, for a total dose of 60/75 Gy on tumor and 50/60 Gy on nodes. In 7 cases radiation therapy was combined with chemotherapy. Actuarial survival at 60 months was 47%; patients with T3 cancer treated with a total tumor dose over 65 Gy showed a significant statistical increase of survival. Adjuvant chemotherapy did not produce statistically significant increase of survival. Radiation therapy was the treatment of choice in nasopharyngeal carcinoma in an advanced stage, whereas the role of chemotherapy remains questionable, even though a bad prognosis requires aggressive and combined treatment.

Adenocarcinoma↗
PubMed1990

[Clinical radiobiology of fast electrons].

The characteristics of microdosimetry, in terms of "lineal energy" value distribution, differ widely between high energy photons and electrons, so as to explain the existence of measurable RBE differences. Nevertheless one can accept for clinical purposes the RBE value 0.9 and a correlated dose increment of 10%. Most important are the macrodosimetric features of electron beams. As far as the skin reactions are concerned, they depend on many factors and are gaining a new relevance in clinical radiotherapy, being a guide in the treatment policy for a given patient.

Electrons↗
PubMed1986

[Prognostic factors in gastric carcinoma].

A personal experiment conducted on 80 gastric carcinoma patients requiring radical surgery at the Special Surgical Pathology Institute is reported. The aim of the study was to identify and assess the factors capable of influencing prognosis e.g. sex, age, TNM, type of operation, symptoms etc and to make a comparison with data from the international literature.

Adult↗
PubMed1985

[Breast cancer. Epidemiology and other factors related to incidence in various populations].

An extensive review of epidemiology, etiology, age, genetic factors, race, alimentary habits and hormonal patterns have been analysed in studies concerning patients with breast cancer. The role of other factors (the age of menopause, the geographic distribution, the action of reserpine and many possible causes) are also discussed. The evidences observed in many studies performed in the last years in different countries are compared but definitive data cannot be reached. The material reported in these studies is not homogeneous and this review can only indicate the problems still present in this field and the subjects we need to investigate in the next years.

Age Factors↗
PubMedDate not supplied

The treadmill test in the assessment of peripheral arterial occlusive disease.

Results of a study using the treadmill test on 32 patients with peripheral Fontaine's stage II arterial disease are described. The aim of the study was to evaluate the utility of the test in assessing useful information concerning the site of the lesion. Patients were divided in three classes depending on the arterial segment involved (iliac-femoral, femoro-popliteal, associated lesions) as resulted from the velocimetric and angiographic evaluation. Ankle pressure and WI, at rest and after stress test, PFWD and RT were evaluated. The authors conclude that data achieved with the dynamic test are related to the arterial involvement, allowing to differentiate obstructive and stenotic lesions, but do not give information concerning the site of the lesion. Nevertheless it is a valuable means of highlighting arterial lesions well compensated at rest and with normal pressure values.

Aged↗