Drug reactions in HIV/AIDS.
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Acquired Immunodeficiency Syndrome↗
Biomedical subjects
M Sanwo
Publications and source records attributed to M Sanwo.
Use of intravenous immunoglobulin in the treatment of severe cutaneous drug reactions in patients with AIDS.
Patients with AIDS have increased frequency of severe cutaneous reactions to certain medications, and these patients often require prolonged hospitalizations because of these reactions. Some reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, appear to involve immune-mediated destruction of cutaneous tissue and therefore respond to antiinflammatory agents. Intravenous immunoglobulin has potent antiinflammatory activity. We have treated two patients with AIDS and severe drug reactions with intravenous immunoglobulin with good outcome. Corticosteroids were avoided because of the potential risk of further immunosuppression in these already immunodeficient patients. Both patients improved rapidly with intravenous immunoglobulin, and hospitalizations for treatment of these reactions were either prevented or shortened because of this treatment. Intravenous immunoglobulin therefore appears to be an effective alternative treatment for severe cutaneous drug reactions in immunodeficient patients.
Acquired Immunodeficiency Syndrome↗
Interferons: their role in clinical practice.
OBJECTIVE: To describe the current indications and side effects of Interferons in the treatment of human disease together with sufficient background information to understand the rationale for their use. DATA SOURCES: Literature searches on interferons extended back to the time of their discovery. Citations were limited to English and human aspects. Reference lists from recent reviews were also consulted. STUDY SELECTION: Reviews of fundamental mechanisms were selected together with studies of individual clinical trials and anecdotal experiences with human use of interferons. CONCLUSIONS: Interferons are accepted therapy for a number of conditions. Their range of therapeutic uses will undoubtedly increase as further knowledge is obtained.
Drug Interactions↗