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Biomedical subjects

M Sarić

Publications and source records attributed to M Sarić.

At least 55 records · Page 3Linked to original sources
PubMed1989

[Possible mechanisms of nonspecific respiratory effects in certain types of occupational exposure].

A summary is made of the author's research related to non-specific respiratory effects of certain types of occupational exposure. Possible mechanisms of such effects are a) repeated mechanical lesions of the mucous membrane in the bronchial part of the respiratory tract, e.g. in prolonged exposure to dusts, b) disturbance in the process of clearance of the alveoli and respiratory pathways, resulting in increased tendency to infection, and chronic damage (manganese), and c) induced hyperreactivity of the bronchi with symptoms of bronchial asthma and faster reduction in ventilatory lung function in relation to the expected fall with regard to age. The possible significance of combined exposure to aerosols of solid particles of small aerodynamic diameter and gaseous irritants is emphasized. By adsorption on dust particles the gaseous irritants of the upper part of the respiratory tract are carried deep into areas not usually penetrated, where, because adsorption is a reversible bond, they are released and can cause a local irritative effect. When evaluating the registered damage the role of other environmental factors should be kept in mind, particularly the habit of smoking, because of the possible supplementary and occasionally synergistic effect.

Air Pollutants, Occupational↗
PubMed1987

A review on occupational health in Yugoslavia.

A review on occupational health service and activities in Yugoslavia is presented. Information on relevant legislation, organization of occupational health and worker's health care, financing, practices of occupational health units, education concerning graduate and postgraduate studies and continuous education in this field are given. Workers' morbidity pattern is also briefly discussed as well as research activities. Concluding remarks include observations on foreseeable needs and developmental orientation in occupational health in the country.

Humans↗
PubMed1986

The role of atopy in potroom workers' asthma.

A study was performed to clarify a possible role of atopy in the occurrence of acute bronchoconstrictive impairment observed in some workers in a plant using the Alu-Swiss process for the electrolytic extraction of aluminum. Of 227 workers examined the percentage of those with a history of atopy and positive skin tests for common allergens was within the expected range. Six had positive patch test with 2% NaF. Among seven workers with paroxysmal wheezing and dyspnea, of whom three were only light smokers, three had positive skin test with common allergens but only one of them had an increased IgE value. The same worker also had positive patch test for 2% NaF. The average age of workers with paroxysmal wheezing and dyspnea was 32.6 years, and only two had symptoms defined as chronic bronchitis. Although their forced expiratory volumes, with two exceptions, measured at the beginning of work shift were within normal limits, in most of those workers bronchial hyperreactivity was also objectively assessed using nonspecific bronchoprovocative tests with histamine (or metacholine). The results support our previous findings that acute respiratory impairment in some workers is most probably based on bronchial hyperreactivity and not on an allergic mechanism.

Adult↗
PubMed1984

Reproduction and exposure to lead.

A study on spontaneous abortions and twinning rate was carried out in a commune with a lead smeltery and in a control commune without a specific source of lead exposure. For a period of 20 years (1961-1980) information on spontaneous abortions was recorded from vital statistics data. Data on twin deliveries were obtained from the birth certificates. The additional information regarding sex of twins, maternal age of delivery and mother's and father's occupations were recorded by an interview. To each twin birth two singleton births were matched by the area of residence and date of birth. Pollution measurements data on lead, zinc and cadmium were also evaluated. The average annual rate of spontaneous abortions in the commune with a lead smeltery was 12/1000 and in the control commune 6.7/1000 fertile women. The cumulative rate of twin births was 2.4/1000 inhabitants in the commune with a lead smeltery and 2.6/1000 inhabitants in the control commune. However, in the commune with a lead smeltery in the area actually exposed to lead the cumulative rate of twin deliveries over 20 years was 1.7/1000 inhabitants and in the rest of the commune it was 2.7/1000 inhabitants. The results indicate a possible interference of lead exposure with reproduction.

Abortion, Spontaneous↗
PubMed1982

Comparison of measured and predicted ventilatory volumes in selected groups of industrial workers.

A follow-up study of ventilatory volumes [forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1.0) and maximum expiratory flow at 50% of the FVC (MEF50)] was conducted for selected groups of workers from two plants involving the electrolytic extraction of aluminum (two groups with 95 and 38 workers, respectively), a cement industry (50 workers with chronic bronchitis and 96 healthy workers)and a shipyard (38 workers) during a period of 3 or 4 a. In the workers from the aluminum plant, particularly in those who were older and exposed longer to respiratory irritants, the fall in FVC was much higher than expected. Cement workers also showed a tendency towards more decreased FVC values than expected, and the fall in MEF50 was particularly pronounced. The cement workers with chronic bronchitis had a slightly higher annual fall in the ventilatory volumes than the healthy cement workers. The observed fall in the MEF50 of the shipyard workers without a specific occupational exposure to dusts or respiratory irritants was unexpectedly high. An analysis of the relative values of the ventilatory volumes within the groups indicated individual differences among the exposed workers in regard to a possible chronic effect of occupational exposure to respiratory irritants. A drop in the ventilatory volumes during the follow-up period was not found to be directly dependent on the initial volume values. In the evaluation of the results, selection factors and ambient exposure to irritants were taken into account.

Adult↗