PubMed Health⌕ Search

Biomedical subjects

M Sas

Publications and source records attributed to M Sas.

At least 19 recordsLinked to original sources
PubMed1991

[Pulsatile gonadotropin-releasing hormone substitution following excision of a craniopharyngioma with suprasellar invasion].

Craniopharyngeoma growing suprasellary attacks the medio-basal region of hypothalamus, that leads to the stopping of the production of gonadotropin releasing hormone. In connection with the case of a 15-year-old girl who had partial extirpation of craniopharyngeoma the authors write about the favourable endocrine effect of pulsatile gonadotropin releasing hormone treatment. Through giving gonadotropin releasing hormone every 90 minutes in 20 micrograms doses menstruation cycle and ovulation was performed. Beside surgical treatment hormonal substitution plays an important role in the treatment of additional endocrine symptoms.

Adolescent↗
PubMed1989

[Treatment of functional infertility, caused by luteal deficiency, with pulsatile perfusion of gonadotropin releasing hormone].

The prehistory of cyclical development of corpus luteum goes back to early follicular phase. Reduced secretion or defective rhythm of gonadotropin releasing hormone (GnRH) can later cause unperfect ovulation or corpus luteum insufficiency. The authors carried out a low-dose pulsatory GnRH-treatment on eight patients with luteal insufficiency, who were earlier treated unsuccessfully with other ovulation-inductive methods (clomiphene, hCG, bromocryptin). As a result of GnRH administration hypertherm period expanded, plasma progesteron level increased and three pregnancies occurred. In their opinion exogenic administration of GnRH results in an improvement of luteal function.

Corpus Luteum Hormones↗
PubMed1989

[Changes in the prolactin level under the effect of pulsatile infusion of gonadotropin releasing hormone].

Plasma prolactin levels were measured in 18 GnRH loading tests and, in 24 cycles involving treatment with GnRH. During 17 GnRH loading tests the prolactin levels production remained virtually unchanged, the individual GnRH pulses not raising the prolactin level. In one case the GnRH loading test led to a considerable rise in prolactin level, which is considered to be a pathological prognostic sign as concerns subsequent GnRH treatment. During unsuccessful pulsatile GnRH treatment, the prolactin secretion in monotonous, while treatment resulting in ovulation, even in hyperprolactinaemia cases, is accompanied by higher prolactin levels in the preovulation and luteal periods than in the early follicular phase.

Adult↗
PubMed1989

[Intrauterine insemination with "washed" sperm].

The authors have been performing intrauterine insemination with the washed sperm of the husband since 1986. Previous to the intervention husband and wife went through a very thorough infertility examination according to the principles of the WHO. The cycle of women given intrauterine insemination was monitored. The maximum value of estradiol was measured on the 12th and 13th day of the cycle and the maximum mean value of the follicles on the 13th-14th day. In cases of ovulation the mean value of serum progesterone was found to rise on the 14th-15th day of the cycle. The semen was washed and concentrated, different protein components and bacteria were eliminated and the fraction with good motility was used for insemination. Intrauterine insemination with washed human sperm was carried out with 2 groups of patients. In the series studied the authors induced with intrauterine insemination 24 pregnancies in 100 infertile marriages. Intrauterine insemination was found to be successful if the infertility was caused by the hostility or poor quality of the cervix mucus. The treatment may be successful also in cases with slighter alteration of the spermiogram, whereas no results can be expected from intrauterine insemination with spermiograms displaying more serious alteration.

Cervix Mucus↗
PubMed1989

Intrauterine insemination with washed sperm.

Intrauterine insemination with washed semen has been carried out in our department since the beginning of 1986. Couples are examined carefully according to the principles of WHO before entering the program. The cycles of those couples treated by intrauterine insemination were monitored. Oestradiol values showed the highest levels on days 13 and 14, such as the size of folliculi, and serum progesterone level increased on days 14 and 15 ovulatory cycle. Insemination was performed with washed sperm after cleansing from it different albumin components and bacteria; the insemination was carried out in two groups. Good results were achieved in cases where the poor quality or hostility of the cervical mucus was the cause of infertility. The treatment can be successful if the spermiogram does not show severe deviation. No success can be expected in severe deviation of the spermiogram.

Estradiol↗
PubMed1989

Ovulation induction with pulsatile administration of human menopausal gonadotropin.

Ovulation induction was performed by the pulsatile administration of subcutaneous human menopausal gonadotropin (hMG). Treatment was started with a daily dose of 75 IU hMG (in a 90% distribution), then it was increased to 150 IU depending on the oestradiol level of the plasma and on the result of folliculometry. Of 10 cycles treated ovulation was induced in 7 cases and two pregnancies occurred. In two cases, following a previous unsuccessful intramuscular hMG treatment, ovulation was induced. Hyperstimulation did not occur. The pulsatile s.c. administration of hMG seems to be an adequate ovulation-induction method in ovulatory disorders of hypothalamo-hypophyseal origin and is a good substitute for the missing, endogenous gonadotropin secretion of inadequate pace.

Adult↗
PubMed1989

Possible means and efficiency of the treatment of infertility.

Diagnostic methods which allowed to understand exactly the mechanism of infertility have been developed within the past four decades. For drug therapy effective gamete production stimulating products have been developed and important progress has been made in operative technique. Due to this progress this condition may be successfully treated in many cases. The effectiveness of treatment depends on the efforts of the given institution to solve this problem and on the willingness of the staff to adapt new diagnostic and therapeutic methods.

Female↗
PubMed1989

Variations in prolactin secretion in hyper- and normoprolactinaemia with or without galactorrhoea.

The circadian variations and secretory rhythms in prolactin secretion were examined in 10 hyperprolactinaemic and 10 normoprolactinaemic women with or without galactorrhoea in order to establish a clearer picture of this secretion and to find, if exists, correlation between the prolactin level and galactorrhoea. In the normoprolactinaemic women a rhythmical rise and fall were observed within 20 min, with higher values during nocturnal sleeping; these changes were more marked in the galactorrhoeic group. In the hyperprolactinaemic group the diurnal and pulsation changes were less pronounced, galatorrhoea usually being accompanied by a higher degree of hyperprolactinaemia. In galactorrhoeic patients with a normal basal prolactin level, a relative prolactin excess may be reckoned with at certain times. A proportion of these women can in fact then be regarded as hyperprolactinaemic. In the hyperprolactinaemic cases without galactorrhoea, a decreased prolactin sensitivity and milk-forming ability of the breasts may be assumed.

Adult↗
PubMed1988

Monitoring of artificial insemination.

Artificial insemination (ADI) has been carried out with donor semen since 1984. Following artificial insemination 14 women out of 27 became pregnant in 1984, 30 women out of 57 in 1985 and 33 women out of 56 until October 1, 1986. The cycles were monitored. Serum LH and oestradiol levels were determined every day from the 10th day of the cycle. Follicle size was monitored daily and cervical mucus was also examined every day. LH reaches the highest level at the time of ovulation. 17-Beta-oestradiol level increases parallel with the growth of follicle. Follicular growth can be best monitored by ultrasound folliculometry, providing 50-60% effectiveness.

Female↗
PubMed1988

Up-to-date surgical management of tubal infertility due to inflammations of the pelvis.

A total of 87 refertilization operations in the distal tubal segment are reported. Tubal obstructions developed following inflammations of the pelvis. Hysterosalpingography and laparoscopy were used to learn about the patients' anatomy and these served as bases for assessing the changes of pregnancy following recanalization. The interventions were made by applying up-to-date microtechnical methods and instruments. Among the causes of tubal infertility, the interruption of the first pregnancy showed a marked prevalence. The 20 pregnancies that ensued correspond to a success rate of 23%. Mature deliveries occurred in 17 cases. A considerable proportion of the pregnancies occurred within a year of the operation. The effectiveness is mainly influenced by adhesions in the pelvis and the characteristics of the distal tubal segment. The surgical solution is worth attempting when the expected chances are over 20%.

Adult↗
PubMed1988

Prolactin release during nursing in early puerperium.

The changes induced in prolactin levels during the first 6 days following delivery were studied. Blood samples for prolactin assay were taken from 9 women at 5-min intervals during breast feeding. The levels of lactation were followed via the amounts of milk produced during suckling. The highest prolactin levels were observed on days 2-4 following delivery. There appeared to be some correlation between the basal and breast-feeding-induced prolactin levels and the level of lactation. A relatively low basal level and a moderate feeding-induced response are early indicators of delayed and less productive lactation. In unfavourable cases the feeding-induced prolactin increases gradually disappeared and lactation stopped. The correlation between the prolactin level and the quantity of milk formed is not a close one, but the observed tendencies agree with the role of prolactin. From day 5 on, the prolactin demands of the breasts are lower.

Female↗