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Biomedical subjects

M Sasoh

Publications and source records attributed to M Sasoh.

At least 19 recordsLinked to original sources
PubMed2006

The use of colour Doppler imaging in the diagnosis of retinal detachment.

DESIGN: Prospective study. PURPOSE: To evaluate real-time duplex colour Doppler examination with colour and pulse Doppler ultrasonography (US) (colour Doppler imaging (CDI)) for detection of the retinal detachment from membranous structures in the posterior segment. MATERIALS AND METHODS: In 33 consecutive patients with ophthalmoscopically invisible eyes (34 eyes), CDI was performed to detect the presence or absence of retinal detachment. The diagnostic criterion for retinal detachment was whether or not spectral waveforms were detected in membranous structures with colour and pulse Doppler US. In all cases, the absence or presence of retinal detachment was confirmed by surgery. RESULTS: In 27 of 34 eyes, membranes and/or opacities were observed in the vitreous cavity with CDI. In 12 of these 27 eyes, blood flow in those structures was detected by CDI. In all of these 12 eyes, retinal detachment was confirmed at surgery, and in 14 of the 15 eyes in which blood flow was not detected by CDI, absence of retinal detachment was confirmed at surgery. When a diagnosis confirmed by surgery was used as the definitive finding, CDI had a sensitivity of 92.3%, specificity of 100%, positive predictive value of 100%, negative predictive value of 93.3%, and an accuracy in the detection of retinal detachment from membranes and/or opacities in the vitreous cavity of 96.3%. CONCLUSION: Real-time duplex colour Doppler examination with colour and pulse Doppler US (CDI) is a noninvasive method useful for the detection of retinal detachment from vitreous opacity and/or membrane in the posterior segment.

Adolescent↗
PubMed2001

[Anterior chamber structural change in postural variation in pseudoexfoliation syndrome].

PURPOSE: The anterior chamber structure in the supine position and the prone position was investigated with ultrasound biomicroscopy (UBM) in pseudoexfoliation syndrome (PE). METHODS: We studied 12 eyes of 12 PE subjects. Patients were placed in the supine position for 30 minutes, after which UBM was performed. The UBM was repeated after 30 minutes in the prone position. Anterior chamber depth (ACD), angle opening distance 500 microns (AOD 500), and angle recess area (ARA) in 4 quadrants were measured. RESULTS: Following the postural change from the supine position to the prone position, ACD decreased significantly (p < 0.0001). AOD 500 and ARA decreased significantly in the superior (AOD 500: p < 0.05, ARA: p = 0.03) and temporal quadrants (AOD 500: p < 0.0001, ARA: p < 0.0001). CONCLUSIONS: The anterior chamber structural change was greater in the temporal and superior quadrants in the PE eyes. This corresponds with previous reports that zonular involvement by pseudoexfoliation material is more pronounced temporally and superiorly.

Anterior Chamber↗
PubMed2001

[Supraciliochoroidal fluid at an early stage after trabeculectomy].

PURPOSE: To examine the supraciliochoroidal fluid(SCF) by ultrasound biomicroscopy(UBM) at an early stage after trabeculectomy. SUBJECTS AND METHODS: Fifteen eyes without post-operative complications were examined by UBM before the operation and less than 2 weeks after trabeculectomy with mitomycin C. RESULTS: SCF was detected postoperatively in 6 eyes. One eye had choroidal detachment under indirect-ophthalmoscope and 5 eyes(33%) had SCF without choroidal detachment. The SCF in 4 eyes disappeared within 4 weeks after trabeculectomy. The intraocular pressure was 6.4 +/- 3.4 mmHg(mean +/- standard deviation) when SCF was detected and it rose to 13.2 +/- 7.2 mmHg when SCF disappeared. The intraocular pressure was 11.4 +/- 4.0 mmHg in the eyes without SCF, which was significantly higher than in the eyes with SCF. CONCLUSION: At an early stage after trabeculectomy, SCF was detected by UBM in some cases without ophthalmoscopic choroidal detachment. Compared with the reported frequency of SCF after 3 or 6 months, our study revealed that SCF was present more frequently at an early stage after trabeculectomy. Our results may indicate that the presence of SCF is related to early low intraocular pressure and that disappearance of SCF induces the elevation of intraocular pressure.

Aged↗
PubMed2000

Retinal pigment epithelial tear and extensive exudative retinal detachment following blunt trauma.

BACKGROUND: A peripheral retinal pigment epithelial tear and an extensive exudative retinal detachment caused by choroidal leakage from the denuded Bruch's membrane are extremely rare. A peripheral retinal pigment epithelial tear has not been reported in an eye with retinochoroidal folds after blunt ocular trauma. METHODS: Case report. RESULTS: The course of a large nasal peripheral retinal pigment epithelial tear that occurred after blunt ocular trauma in a patient with retinochoroidal folds was followed. The inferior retinal detachment caused by leakage from the denuded Bruch's membrane following the development of the tear gradually worsened. Initial treatment with cryotherapy was ineffective, but the retinal detachment eventually resolved after the patient underwent sclerectomy and sclerostomy. CONCLUSION: A large peripheral retinal pigment epithelial tear can occur in patients with retinochoroidal folds following blunt ocular trauma, and extensive retinal detachment can be induced. Sclerectomy and sclerostomy can be beneficial in patients with an extensive exudative retinal detachment caused by choroidal leakage from the denuded Bruch's membrane.

Adult↗
PubMed2000

Macular buckling for retinal detachment due to macular hole in highly myopic eyes with posterior staphyloma.

PURPOSE: To evaluate the efficacy of macular buckling surgery using a special exoplant. METHODS: The authors reviewed 33 cases of patients with retinal detachment due to macular hole with posterior staphyloma who underwent a macular bucking procedure and 11 cases of patients with the same condition due to macular hole without posterior staphyloma or due to a hole along the edge of the posterior staphyloma who underwent gas injection or vitrectomy. The reattachment rate, visual acuity (VA), and area size (V-4, I-4 isopter) by Goldmann perimetry were calculated. RESULTS: Reattachment rate for the macular buckling procedure was 94% (initial) and 100% (final), and that for the gas injection or vitrectomy was 100% (both initial and final). Twenty of the 33 eyes (60.6%) had VA of 20/400 or better, and none of these 33 eyes had a VA at the level of finger counting or poorer following macular buckling. Nine of the 11 eyes (81.8%) had VA of 20/400 or better, and none of these 11 eyes had a VA at the level of finger counting or poorer following the gas injection or vitrectomy. The area size of V-4 isopter in the macular buckling group was significantly larger than that in the gas injection or vitrectomy group (P = 0.017). CONCLUSION: The macular buckling procedure is effective when considered both from an anatomic and a functional perspective for retinal detachment due to macular hole with posterior staphyloma.

Aged↗
PubMed1998

Immunocytochemical localization of glutamate in normal and detached cat retina.

PURPOSE: Glutamate immunoreactivity in the mammalian retina has generally been observed using immersion fixation. The authors investigated glutamate immunoreactivity in the detached cat retina and reevaluated this activity in the normal retina using rapid fixation by perfusion. METHODS: Unilateral retinal detachment was produced in cats by injecting 0.25% sodium hyaluronate into the subretinal space using a glass micropipet. The eyes were fixed by perfusion with a mixture of 1% glutaraldehyde and 4% formaldehyde 10 minutes and 60 minutes after detachment, and then they were examined by conventional light and electron microscopic immunocytochemistry. RESULTS: In contrast to previous reports based on immersion fixation, the inner segment was not glutamate immunopositive in the normal retina. The inner segment showed intense glutamate immunoreactivity 10 minutes and 60 minutes after retinal detachment. CONCLUSIONS: Glutamate immunoreactivity in photoreceptor inner segments may be a postmortem change induced by strong ischemia. Perfusion fixation is of critical importance when studying the immunocytochemical distribution of glutamate in the retina.

Animals↗
PubMed1998

Quantification of holmium: YAG and thulium: YAG laser-induced scleral shrinkage for buckling procedures.

BACKGROUND AND OBJECTIVE: To quantify and compare holmium:YAG (2.1 microns) and thulium:YAG (2.0 microns) laser-induced scleral shrinkage for retinal buckling procedures. MATERIALS AND METHODS: Two overlapping spots of either laser radiation were applied at the equatorial sclera of 50 human cadaver eyes. Scleral shrinkage was expressed as a relative change of length between two reference points on the scleral surface, and quantified as a function of energy per pulse, total energy, scleral thickness, and intraocular pressure (IOP). Tissue effects were studied histopathologically. RESULTS: Shrinkage was most dependent on total fluence and attained a maximum of 27% to 30% with an IOP of 4 mm Hg, regardless of scleral thickness or laser parameters, but decreased with increasing IOP. The thulium:YAG laser produced more efficient scleral shrinkage and less collagen damage than the holmium:YAG laser. CONCLUSION: The recommended parameters for laser-induced scleral shrinkage are the thulium:YAG laser, with 2.4 J/cm2 per pulse and 12.0 to 14.4 J/cm2 total fluence (5 to 6 pulses). IOP control (< or = 4 mm Hg) is crucial during laser scleral buckling.

Humans↗
PubMed1997

Ultrasound biomicroscopic view of detachment of the ciliary epithelium in retinal detachment with atopic dermatitis.

PURPOSE: The authors evaluated the effectiveness of ultrasound biomicroscopy to determine the condition of the ciliary body during perioperative examinations of patients with atopic dermatitis and retinal detachment. METHODS: The authors compared two groups of patients with atopic dermatitis and retinal detachment. Parameters included patient age, gender, eye, cataract, type and location of breaks, macular involvement, detachment of the ciliary epithelium, and preoperative and postoperative best-corrected visual acuities. Group 1 included six patients (nine eyes) who were examined before surgery and after surgery using ultrasound biomicroscopy, with which the authors also measured the maximum height of the detachment of the ciliary epithelium. Group 2 included 10 patients (13 eyes) who did not undergo ultrasound biomicroscopy. RESULTS: In group 1, ultrasound biomicroscopy showed ciliary epithelium detachment in all eyes before surgery and in eight of nine eyes after successful retinal reattachment. The height of the ciliary detachment, however, decreased dramatically after surgery. Although almost all the parameters between groups 1 and 2 were similar, the authors observed a significant difference in the incidence of preoperative diagnosis of ciliary detachment (P = 0.023). CONCLUSION: Ultrasound biomicroscopy is beneficial in detecting detachment of the ciliary epithelium. The residual shallow detachment that remains after successful surgery suggests the fragility of the ciliary body.

Adolescent↗
PubMed1995

Diode laser endophotocoagulation.

PURPOSE: To evaluate the utility, safety, and reliability of diode laser endophotocoagulation in a sizable clinical series. METHODS: Two hundred twenty-six consecutive eyes treated with diode endophotocoagulation were studied prospectively. Surgical indications included proliferative diabetic retinopathy (134 eyes), proliferative vitreoretinopathy (27 eyes), complicated retinal detachment (50 eyes), and miscellaneous (15 eyes). A retrospective comparison group of 67 consecutive eyes undergoing vitrectomy with argon endolaser photocoagulation was also studied. RESULTS: The desired intraoperative effect of diode endophotocoagulation was achieved in 99.6% cases without complication. Final visual acuity was improved in 159 eyes (71%), and was 5/200 or better in 157 eyes (70%) with diode endophotocoagulation. In comparison, final visual acuity was improved in 48 eyes (73%), and was 5/200 or better in 45 eyes (68%) for argon endophotocoagulation. No statistically significant difference was found between the two groups regarding rate of visual improvement or final visual results. CONCLUSION: This series supports the conclusion that the diode laser is as safe, reliable, and effective for endophotocoagulation as argon treatment.

Adolescent↗
PubMed1995

[A case of nonarteritic anterior ischemic optic neuropathy with cilioretinal artery occlusion].

We report a case of nonarteritic anterior ischemic optic neuropathy (AION) with cilioretinal artery occlusion. The patient was a 61-year-old man with sudden visual loss in his right eye. Funduscopy showed pale swelling of the entire optic disc with retinal ischemic edema of the upper half of the retina, and fluorescein angiography revealed faint filling of the dye in the optic disc in the retinal arterial phase, and dye staining of the optic disc in the late phase. We initially diagnosed the disease as AION with branch retinal artery occlusion, but systemic administration of a corticosteroid and urokinase were ineffective and the optic disc became atrophic. As the optic disc swelling decreased and the course of arteries in the optic disc became clear, we repeated fluorescein angiography which proved that the involved upper retinal artery was a cilioretinal artery having earlier dye appearance than the lower retinal artery. Thus, we finally diagnosed the disease as AION with cilioretinal artery occlusion. We believe that Hayreh's view that AION may result from occlusion of the posterior ciliary artery is supported by the intraocular findings in this case.

Ciliary Body↗
PubMed1994

Displaced retinal ganglion cells in the Chinese hamster.

The size, number, distribution and dendritic morphology of displaced retinal ganglion cells (DGCs) in normal Chinese hamsters were investigated using horseradish peroxidase. The diameters of DGC soma ranged from 4 to 23 microns (mean 11.7 microns). The number of DGCs ranged from 104 to 453 (mean 249) and constituted under 1% of total retinal ganglion cells. DGCs were found in all retinal regions, but more frequently in the lower temporal periphery. Two types of DGCs were observed, one with a small to medium soma (< 18 microns in diameter) and a small dendritic field (< 100 microns in diameter), and the other with a large soma (> or = 18 microns in diameter) and a large dendritic field (> or = 100 microns in diameter). DGCs in the Chinese hamster may be developmental errors or misplaced ganglion cells.

Animals↗
PubMed1993

[Long-term results of transscleral retinal detachment surgery with special reference to visual function].

We studied visual acuity and visual field of 44 eyes in 42 patients who had undergone transscleral retinal detachment surgery, they were classified into a preoperative group, a postoperative group, and a group ten years after surgery. With regard to visual acuity, the postoperative group showed a significant increase compared with the preoperative group (p < 0.001), and there was no significance between the postoperative group and the group ten years after surgery. In order to quantify the visual field obtained by Goldmann perimeter, the areal size of V-4 isopter, the areal size of I-4 isopter and the volume of the visual field were adopted in the present study. Each of the three mean values was high in the following order: the group ten years after surgery, the postoperative group, and the preoperative group. The mean value of the group ten years after surgery was respectively equivalent to 80.6%, 65.5%, and 71.1% of that of normal control in the order: the areal size of V-4 isopter, the areal size of I-4 isopter, and the volume of the visual field. Our results support the conclusion that the visual acuity acquired postoperatively can be maintained for ten years after surgery. The visual field acquired postoperatively also seems to be retained ten years after surgery.

Adolescent↗
PubMed1993

Retinal detachment due to breaks in pars plicata of ciliary body after endogenous fungal endophthalmitis.

An eye with retinal detachment due to breaks in the nonpigmented epithelium in the pars plicata of the ciliary body was reported in a patient who had been infected by endogenous Candida endophthalmitis about 3 years previously. He had no history of ocular trauma or atopic dermatitis, and had undergone extracapsular cataract extraction because of secondary cataract following the endophthalmitis. Three months later, the breaks were detected in his right eye, distributed extensively between the 3:30 and 11:45 o'clock meridians in the pars plicata. The posterior edges of these breaks were pulled to the contracted posterior capsule by zonular fibers. Posterior capsulectomy, vitrectomy, encircling and scleral buckling were performed and resulted in the reattachment of the retina. It was suggested that the ciliary body which had been damaged by endophthalmitis played a role in the development of these breaks.

Candidiasis↗
PubMed1992

The frequency of subretinal fluid drainage and the reattachment rate in retinal detachment surgery.

The reattachment rate and the frequency of subretinal fluid drainage were reviewed in 771 eyes with rhegmatogenous retinal detachment that had undergone transscleral retinal detachment surgery between January, 1980 and December, 1989. During this period, the frequency of drainage decreased from 63.6% in 1980 to 14.1% in 1989. This decrease has not been accompanied by any change in the reattachment rate. The difference between visual acuity in eyes that underwent the operation when drainage was performed in only certain selected cases and visual acuity in eyes operated on when drainage was performed more frequently was not statistically significant (P = 0.966). It is suggested that the decrease in the frequency of drainage was due to a carefully followed method of patient management, including preoperative bed rest, use of criteria to establish nondrainage operation, use of transilluminator, and control of intraocular pressure.

Drainage↗